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Lhx6
Gene Detail
Symbol

Name
ID
Lhx6
LIM homeobox protein 6
MGI:1306803
Feature Type
protein coding gene
Genetic Map
Chromosome 2
24.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:36081953-36105408 bp, - strand
From VEGA annotation of GRCm38

  23456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LHX6
Gene Tree: Lhx6

Human
homologs
LHX6, LIM homeobox 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 26468
neXtProt AC: NX_Q9UPM6

Human Synonyms: LHX6.1

Human Chr (Location): 9q33.2; chr9:122185652-122228893 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in impaired migration and specification of cortical interneurons, postnatal lethality and weakness.
 
Interactions
Lhx6 interacts with 330 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, cell maturation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (135 records)
Data Summary: Results (337)    Tissues (297)    Images (88)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 331
RNase protection 6
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LHX6 ZFIN lhx6    NEW 
Molecular
reagents
All nucleic(24) cDNA(19) Primer pair(1) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000012098 (Evidence)
Ensembl Gene Model ENSMUSG00000026890 (Evidence)
Entrez Gene 16874 (Evidence)
UniGene 12881
DFCI TC1593267, TC1587368, TC1592936
DoTS DT.91329759, DT.97367093, DT.101285808, DT.91335619, DT.97403594
NIA Mouse Gene Index U022549
Consensus CDS Project CCDS38110.1, CCDS38111.1, CCDS38112.1, CCDS38113.1
International Mouse Phenotyping Consortium Status Lhx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012098 VEGA Gene Model | MGI Sequence Detail 23456 C57BL/6J ±  kb
transcript OTTMUST00000028787 VEGA | MGI Sequence Detail 3345 Not Applicable 
polypeptide OTTMUSP00000013031 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(13) UniProt(6)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000032533 LIM/homeobox protein Lhx6
References
(Earliest) J:48134 Grigoriou M, et al., Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(172)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory