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Lhx6 Gene Detail
Summary
  • Symbol
    Lhx6
  • Name
    LIM homeobox protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306803
    NCBI Gene: 16874
  • Gene Overview
    MyGene.info: LHX6
Location & Maps
more
  • Sequence Map
    Chr2:36081953-36105408 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23456 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LHX6, LIM homeobox 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHX6, LIM homeobox 6
    Orthology source: HomoloGene
  • Synonyms
    LHX6.1
  • Links
    NCBI Gene ID: 26468
    neXtProt AC: NX_Q9UPM6

  • Chr Location
    9q33.2; chr9:122185652-122228893 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7401
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LHX6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    7
  • Incidental Mutations
    APF
Homozygous mutation of this gene results in impaired migration and specification of cortical interneurons, postnatal lethality and weakness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012098 VEGA Gene Model | MGI Sequence Detail 23456 C57BL/6J ±  kb
transcript OTTMUST00000028787 VEGA | MGI Sequence Detail 3345 Not Applicable  
polypeptide OTTMUSP00000013031 VEGA | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    cDNA 21
    Primer pair 1
    Other 5

    Microarray probesets 4
References
more
  • Summaries
    All 179
    Developmental Gene Expression 144
    Gene Ontology 7
    Phenotypes 23
  • Earliest
    J:48134 Grigoriou M, et al., Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
  • Latest
    J:228726 Golonzhka O, et al., Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory