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Lhx6
Gene Detail
 Symbol
Name
ID
Lhx6
LIM homeobox protein 6
MGI:1306803
Feature Type protein coding gene
Genetic Map
Chromosome 2
24.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:36081953-36105408 bp, - strand
From VEGA annotation of GRCm38

  23456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lhx6

Human
homologs
Human Homolog LHX6, LIM homeobox 6
NCBI Gene ID 26468
neXtProt AC  NX_Q9UPM6
Human Synonyms  LHX6.1
Human Chr (Location)  9q33.2; chr9:122202577-122228887 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in impaired migration and specification of cortical interneurons, postnatal lethality and weakness.
 
Interactions
Lhx6 interacts with 331 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell differentiation, cell maturation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (127 records)
Data Summary: Results (337)    Tissues (297)    Images (88)
Theiler Stages: 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 331
RNase protection 6
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(19) Primer pair(1) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012098 (Evidence)
Ensembl Gene ModelENSMUSG00000026890 (Evidence)
Entrez Gene16874 (Evidence)
UniGene12881
DFCITC1587368, TC1592936, TC1593267
DoTSDT.101285808, DT.91329759, DT.91335619, DT.97367093, DT.97403594
NIA Mouse Gene IndexU022549
Consensus CDS ProjectCCDS38110.1, CCDS38111.1, CCDS38112.1, CCDS38113.1
International Mouse Knockout Project StatusLhx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012098 VEGA Gene Model | MGI Sequence Detail 23456 C57BL/6J ±  kb
transcript OTTMUST00000028787 VEGA | MGI Sequence Detail 3345 Not Applicable 
polypeptide OTTMUSP00000013031 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(17) UniProt(6)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000032533 LIM/homeobox protein Lhx6
References (Earliest) J:48134 Grigoriou M, et al., Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
(Latest) J:211630 Zhu Y, et al., Genetically targeted binary labeling of retinal neurons. J Neurosci. 2014 Jun 4;34(23):7845-61
All references(162)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory