Lhx6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lhx6
LIM homeobox protein 6
MGI:1306803

19 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lhx6^{tm1(cre/ERT2)Zjh}/Lhx6⁺ involves: C57BL/6	no abnormal phenotype detected	J:151755
Lhx6^{tm1b(KOMP)Wtsi}/Lhx6⁺ C57BL/6N-Lhx6^{tm1b(KOMP)Wtsi}/Ucd	decreased locomotor activity	J:211773
Lhx6^{tm1b(KOMP)Wtsi}/Lhx6^{tm1b(KOMP)Wtsi} C57BL/6N-Lhx6^{tm1b(KOMP)Wtsi}/Ucd	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Lhx6^tm1Vpa/Lhx6^tm1Vpa involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:198547
Lhx6^tm1Vpa/Lhx6^tm2Vpa involves: 129P2/OlaHsd * C57BL/6	abnormal brain interneuron morphology	J:198547
	abnormal neuron differentiation	J:198547
	abnormal spike wave discharge	J:198547
	decreased neuron number	J:198547
	environmentally induced seizures	J:198547
	increased miniature inhibitory postsynaptic current frequency	J:198547
	increased susceptibility to pharmacologically induced seizures	J:198547
	normal nervous system phenotype	J:198547
	tonic-clonic seizures	J:198547
Lhx6^tm2Vpa/Lhx6^tm2Vpa involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal brain interneuron morphology	J:119476
	abnormal cerebral cortex morphology	J:119476
	abnormal hippocampus morphology	J:119476
	abnormal neuronal migration	J:119476
	postnatal lethality, complete penetrance	J:119476
	weakness	J:119476
Lhx6^tm2Vpa/Lhx6^tm2Vpa involves: 129P2/OlaHsd * C57BL/6	abnormal brain interneuron morphology	J:198547
	abnormal inhibitory postsynaptic currents	J:198547
	decreased neuron number	J:198547

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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