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Ap2m1
Gene Detail
Symbol

Name
ID
Ap2m1
adaptor-related protein complex 2, mu 1 subunit
MGI:1298405
Synonyms
clathrin-associated AP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.46 cM, cytoband 16
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:20535478-20544909 bp, + strand
From VEGA annotation of GRCm38

  9432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: AP2M1
Protein SuperFamily: adaptor protein complex, mu subunit
Gene Tree: Ap2m1

Human
homologs
AP2M1, adaptor-related protein complex 2, mu 1 subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1173
neXtProt AC: NX_Q96CW1

Human Synonyms: AP50, CLAPM1, mu2

Human Chr (Location): 3q28; chr3:184174846-184184091 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted deletion display embryonic lethality before implantation.
 
Interactions
Ap2m1 interacts with 203 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process endocytosis, intracellular protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function lipid binding, low-density lipoprotein particle receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (93)    Tissues (93)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
cDNA source data(233)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap2m1 ; ZFIN ap2m1a, ap2m1b    NEW 
Molecular
reagents
All nucleic(240) Genomic(4) cDNA(233) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025969 (Evidence)
Ensembl Gene Model ENSMUSG00000022841 (Evidence)
Entrez Gene 11773 (Evidence)
UniGene 18946
DFCI TC1573313
NIA Mouse Gene Index U043506, U082560, U137015
Consensus CDS Project CCDS28048.1, CCDS79436.1
International Mouse Phenotyping Consortium Status Ap2m1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025969 VEGA Gene Model | MGI Sequence Detail 9432 C57BL/6J ±  kb
transcript OTTMUST00000064275 VEGA | MGI Sequence Detail 2937 Not Applicable 
polypeptide OTTMUSP00000031894 VEGA | MGI Sequence Detail 435 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR001392 Clathrin adaptor, mu subunit
InterPro IPR018240 Clathrin adaptor, mu subunit, conserved site
InterPro IPR011012 Longin-like domain
InterPro IPR028565 Mu homology domain
Protein Ontology PR:000004102 AP-2 complex subunit mu
References
(Earliest) J:28934 Ohno H, et al., Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29;269(5232):1872-5
(Latest) J:214740 Kononenko NL, et al., Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron. 2014 Jun 4;82(5):981-8
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory