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Ap2m1
Gene Detail
 Symbol
Name
ID
Ap2m1
adaptor-related protein complex 2, mu 1 subunit
MGI:1298405
Synonyms clathrin-associated AP-2
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.46 cM, cytoband 16
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:20535478-20544909 bp, + strand
From VEGA annotation of GRCm38

  9432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: adaptor protein complex, mu subunit
Gene Tree: Ap2m1

Human
homologs
Human Homolog AP2M1, adaptor-related protein complex 2, mu 1 subunit
NCBI Gene ID 1173
neXtProt AC  NX_Q96CW1
Human Synonyms  AP50, CLAPM1, mu2
Human Chr (Location)  3q28; chr3:184174846-184184091 (+)  GRCh38
Alleles
and
phenotypes
All alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted deletion display embryonic lethality before implantation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process endocytosis, intracellular protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function lipid binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (93)    Tissues (93)    Images (16)
Theiler Stages: 22
Assay TypeResults
RNA in situ 93
cDNA source data(233)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(240) Genomic(4) cDNA(233) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025969 (Evidence)
Ensembl Gene ModelENSMUSG00000022841 (Evidence)
Entrez Gene11773 (Evidence)
UniGene18946
DFCITC1573313
NIA Mouse Gene IndexU043506, U137015
Consensus CDS ProjectCCDS28048.1
International Mouse Knockout Project StatusAp2m1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025969 VEGA Gene Model | MGI Sequence Detail 9432 C57BL/6J ±  kb
transcript OTTMUST00000064275 VEGA | MGI Sequence Detail 2937 Not Applicable 
polypeptide OTTMUSP00000031894 VEGA | MGI Sequence Detail 435 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR001392 Clathrin adaptor, mu subunit
InterPro IPR018240 Clathrin adaptor, mu subunit, conserved site
InterPro IPR008968 Clathrin adaptor, mu subunit, C-terminal
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004102 AP-2 complex subunit mu
References (Earliest) J:28934 Ohno H, et al., Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29;269(5232):1872-5
(Latest) J:198657 Duncker SV, et al., Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci. 2013 May 29;33(22):9508-19
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory