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Gzmk
Gene Detail
 Symbol
Name
ID
Gzmk
granzyme K
MGI:1298232
Feature Type protein coding gene
Genetic Map
Chromosome 13
63.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:113171608-113225908 bp, - strand
From VEGA annotation of GRCm38

  54301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Gzmk

Human
homologs
Human Homolog GZMK, granzyme K (granzyme 3; tryptase II)
NCBI Gene ID 3003
neXtProt AC  NX_P49863
Human Synonyms  TRYP2
Human Chr (Location)  5q11.2; chr5:55024279-55034132 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
Interactions
Gzmk interacts with 97 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process proteolysis
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (36)   
Theiler Stages: 15, 26, 28
Assay TypeResults
RNA in situ 39
RT-PCR 16
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(5) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027683 (Evidence)
Ensembl Gene ModelENSMUSG00000042385 (Evidence)
Entrez Gene14945 (Evidence)
UniGene56993
DFCITC1596289
DoTSDT.87028245, DT.91583362
NIA Mouse Gene IndexU035188
EC3.4.21.-
Consensus CDS ProjectCCDS26783.1
International Mouse Knockout Project StatusGzmk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027683 VEGA Gene Model | MGI Sequence Detail 54301 C57BL/6J ±  kb
transcript OTTMUST00000068495 VEGA | MGI Sequence Detail 1028 Not Applicable 
polypeptide OTTMUSP00000034650 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(928 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003472 granzyme K
References (Earliest) J:49361 Shresta S, et al., Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem. 1997 Aug 8;272(32):20236-44
(Latest) J:203610 Zhong C, et al., Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells. Cell Death Differ. 2012 May;19(5):882-90
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory