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Gzmk
Gene Detail
Symbol

Name
ID
Gzmk
granzyme K
MGI:1298232
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:113171608-113225908 bp, - strand
From VEGA annotation of GRCm38

  54301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: GZMK
Protein SuperFamily: trypsin
Gene Tree: Gzmk

Human
homologs
GZMK, granzyme K (granzyme 3; tryptase II)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3003
neXtProt AC: NX_P49863

Human Synonyms: TRYP2

Human Chr (Location): 5q11.2; chr5:55024279-55034132 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
Interactions
Gzmk interacts with 97 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process proteolysis
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
RT-PCR 16
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(5) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027683 (Evidence)
Ensembl Gene Model ENSMUSG00000042385 (Evidence)
Entrez Gene 14945 (Evidence)
UniGene 56993
DFCI TC1596289
DoTS DT.87028245, DT.91583362
NIA Mouse Gene Index U035188
EC 3.4.21.-
Consensus CDS Project CCDS26783.1
International Mouse Phenotyping Consortium Status Gzmk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027683 VEGA Gene Model | MGI Sequence Detail 54301 C57BL/6J ±  kb
transcript OTTMUST00000068495 VEGA | MGI Sequence Detail 1028 Not Applicable 
polypeptide OTTMUSP00000034650 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(928 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003472 granzyme K
References
(Earliest) J:49361 Shresta S, et al., Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem. 1997 Aug 8;272(32):20236-44
(Latest) J:208859 Wensink AC, et al., Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5974-9
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory