Crygs
Gene Detail

Symbol Name ID

Crygs crystallin, gamma S MGI:1298216

Synonyms

Opj

Feature Type

protein coding gene

Genetic Map

Chromosome 16

13.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr16:22805203-22811410 bp, - strand From NCBI annotation of GRCm38   6208 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygs

Human homologs

Human Homolog		CRYGS, crystallin, gamma S
NCBI Gene ID		1427
neXtProt AC		NX_P22914
Human Synonyms		CRYG8
Human Chr (Location)		3q27.3; chr3:186256232-186262167 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CRYGS

Alleles and phenotypes

All alleles(3) : Targeted(1) Spontaneous(1) Chemically induced(1)
 

Heterozygotes for an ethylnitrosourea-induced, amino acid replacement mutation exhibit a mild, slowly progressive cataract. Homozygotes exhibit a more severe cataract which progresses to total opacity by 3.5 months.

 
Human Diseases Modeled Using Mouse Crygs (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	lens development in camera-type eye, morphogenesis of an epithelium
Function	structural constituent of eye lens

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033501 (Evidence)
Entrez Gene	12970 (Evidence)
UniGene	6253
DFCI	TC1582591
DoTS	DT.40143315
NIA Mouse Gene Index	U036914
PDB	1ZWM, 1ZWO, 2A5M
Consensus CDS Project	CCDS28069.1
International Mouse Knockout Project Status	Crygs

Sequences

Length	Strain/Species
genomic	12970	NCBI Gene Model | MGI Sequence Detail	6208	C57BL/6J
transcript	NM_009967	RefSeq | MGI Sequence Detail	708	C57BL/6
polypeptide	O35486	UniProt | EBI | MGI Sequence Detail	178	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000005919	beta-crystallin S

Graphical View of Protein Domain Structure

References

(Earliest) J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
(Latest) J:181639 Wende H, et al., The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6
All references(32)

Other accession IDs

MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437