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Crygs Gene Detail
Summary
  • Symbol
    Crygs
  • Name
    crystallin, gamma S
  • Synonyms
    Opj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298216
    NCBI Gene: 12970
  • Gene Overview
    MyGene.info: CRYGS
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22805203-22811410 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.66 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298216
protein coding gene Chr16:22805203-22811410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022671
protein coding gene Chr16:20325205-20331442 (-)
A/J MGP_AJ_G0022632
protein coding gene Chr16:19344744-19350956 (-)
AKR/J MGP_AKRJ_G0022607
protein coding gene Chr16:20156387-20162598 (-)
BALB/cJ MGP_BALBcJ_G0022637
protein coding gene Chr16:19546684-19552894 (-)
C3H/HeJ MGP_C3HHeJ_G0022401
protein coding gene Chr16:20257161-20263367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023087
protein coding gene Chr16:20768025-20774230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020605
protein coding gene Chr16:20037404-20043351 (-)
CAST/EiJ MGP_CASTEiJ_G0021931
protein coding gene Chr16:20261529-20267755 (-)
CBA/J MGP_CBAJ_G0022373
protein coding gene Chr16:21640894-21647091 (-)
DBA/2J MGP_DBA2J_G0022505
protein coding gene Chr16:19325308-19331879 (-)
FVB/NJ MGP_FVBNJ_G0022481
protein coding gene Chr16:19295229-19301705 (-)
LP/J MGP_LPJ_G0022573
protein coding gene Chr16:20082810-20089326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022500
protein coding gene Chr16:21183756-21191430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023098
protein coding gene Chr16:20103211-20110313 (-)
PWK/PhJ MGP_PWKPhJ_G0021671
protein coding gene Chr16:19570305-19576483 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021501
protein coding gene Chr16:19888726-19894902 (-)
WSB/EiJ MGP_WSBEiJ_G0021974
protein coding gene Chr16:20066564-20072766 (-)



Homology
more
  • Human Ortholog
    CRYGS, crystallin gamma S
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYGS, crystallin gamma S
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRYG8, CTRCT20
  • Links
    NCBI Gene ID: 1427
    neXtProt AC: NX_P22914
    UniProt: P22914

  • Chr Location
    3q27.3; chr3:186538443-186544378 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Crygs mouse models; 1 with human CRYGS associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene can cause cataracts and/or disrupted lens fiber cell morphology and organization. Aging mice homozygous for a knock-out allele do not develop cataracts but show focusing defects associated with inefficient clearance of cellular organelles and altered actin distribution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12970 NCBI Gene Model | MGI Sequence Detail 6208 C57BL/6J ±  kb
transcript NM_009967 RefSeq | MGI Sequence Detail 708 C57BL/6  
polypeptide O35486 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 1
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
  • Latest
    J:251150 Aoki H, et al., Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory