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Crygs
Gene Detail
Symbol

Name
ID
Crygs
crystallin, gamma S
MGI:1298216
Synonyms
Opj
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:22805203-22811410 bp, - strand
From NCBI annotation of GRCm38

  6208 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: CRYGS
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygs

Human
homologs
CRYGS, crystallin, gamma S
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1427
neXtProt AC: NX_P22914

Human Synonyms: CRYG8, CTRCT20

Human Chr (Location): 3q27.3; chr3:186538443-186544378 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYGS

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from APF )
Human Diseases Modeled in Mice Using Crygs (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Crygs interacts with 13 markers (Mir325, Mir465, Mir465b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process lens development in camera-type eye, morphogenesis of an epithelium
Function structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase MGC89845    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033501 (Evidence)
Entrez Gene 12970 (Evidence)
UniGene 6253
DFCI TC1582591
DoTS DT.40143315
NIA Mouse Gene Index U036914
PDB 1ZWM, 1ZWO, 2A5M
Consensus CDS Project CCDS28069.1
International Mouse Phenotyping Consortium Status Crygs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12970 NCBI Gene Model | MGI Sequence Detail 6208 C57BL/6J ±  kb
transcript NM_009967 RefSeq | MGI Sequence Detail 708 C57BL/6 
polypeptide O35486 UniProt | EBI | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005919 beta-crystallin S
Graphical View of Protein Domain Structure
References
(Earliest) J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
(Latest) J:201031 Fan J, et al., A role for gammaS-crystallin in the organization of actin and fiber cell maturation in the mouse lens. FEBS J. 2012 Aug;279(16):2892-904
All references(31)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory