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Crygs
Gene Detail
Symbol

Name
ID
Crygs
crystallin, gamma S
MGI:1298216
Synonyms
Opj
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:22805203-22811410 bp, - strand
From NCBI annotation of GRCm38

  6208 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygs

Human
homologs
Human Homolog CRYGS, crystallin, gamma S
NCBI Gene ID 1427
neXtProt AC  NX_P22914
Human Synonyms  CRYG8, CTRCT20
Human Chr (Location)  3q27.3; chr3:186538443-186544378 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRYGS
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(2)
Incidental mutations (data from APF )
 
Heterozygotes for an ethylnitrosourea-induced, amino acid replacement mutation exhibit a mild, slowly progressive cataract. Homozygotes exhibit a more severe cataract which progresses to total opacity by 3.5 months.
 
Human Diseases Modeled Using Mouse Crygs (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Crygs interacts with 13 markers (Mir325, Mir465, Mir465b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process lens development in camera-type eye, morphogenesis of an epithelium
Function structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033501 (Evidence)
Entrez Gene12970 (Evidence)
UniGene6253
DFCITC1582591
DoTSDT.40143315
NIA Mouse Gene IndexU036914
PDB1ZWM, 1ZWO, 2A5M
Consensus CDS ProjectCCDS28069.1
International Mouse Knockout Project StatusCrygs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12970 NCBI Gene Model | MGI Sequence Detail 6208 C57BL/6J ±  kb
transcript NM_009967 RefSeq | MGI Sequence Detail 708 C57BL/6 
polypeptide O35486 UniProt | EBI | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005919 beta-crystallin S
Graphical View of Protein Domain Structure
References
(Earliest) J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
(Latest) J:201031 Fan J, et al., A role for gammaS-crystallin in the organization of actin and fiber cell maturation in the mouse lens. FEBS J. 2012 Aug;279(16):2892-904
All references(32)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-13035, MGI:1890491, MGI:2146420, MGI:97437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory