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Hcn2 Gene Detail
Summary
  • Symbol
    Hcn2
  • Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 2
  • Synonyms
    HAC1, trls
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298210
    NCBI Gene: 15166
  • Gene Overview
    MyGene.info: HCN2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79716634-79736108 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298210
protein coding gene Chr10:79716634-79736108 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017455
protein coding gene Chr10:80258824-80278257 (+)
A/J MGP_AJ_G0017433
protein coding gene Chr10:77469400-77489767 (+)
AKR/J MGP_AKRJ_G0017394
protein coding gene Chr10:79575199-79596168 (+)
BALB/cJ MGP_BALBcJ_G0017395
protein coding gene Chr10:77696054-77715493 (+)
C3H/HeJ MGP_C3HHeJ_G0017218
protein coding gene Chr10:79683598-79703053 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017849
protein coding gene Chr10:83033696-83053165 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015537
protein coding gene Chr10:73695720-73714921 (+)
CAST/EiJ MGP_CASTEiJ_G0016785
protein coding gene Chr10:79856615-79877295 (+)
CBA/J MGP_CBAJ_G0017190
protein coding gene Chr10:86255441-86277170 (+)
DBA/2J MGP_DBA2J_G0017296
protein coding gene Chr10:76685215-76704666 (+)
FVB/NJ MGP_FVBNJ_G0017290
protein coding gene Chr10:75847284-75868112 (+)
LP/J MGP_LPJ_G0017367
protein coding gene Chr10:80738235-80758620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017316
protein coding gene Chr10:88236562-88255955 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017890
protein coding gene Chr10:79552306-79571823 (+)
PWK/PhJ MGP_PWKPhJ_G0016566
protein coding gene Chr10:76542662-76562521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016355
protein coding gene Chr10:78526316-78545582 (+)
WSB/EiJ MGP_WSBEiJ_G0016845
protein coding gene Chr10:79584885-79604329 (+)



Homology
more
  • Human Ortholog
    HCN2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HCN2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCNG2, BCNG-2, HAC-1
  • Links
    NCBI Gene ID: 610
    neXtProt AC: NX_Q9UL51
    UniProt: Q9UL51

  • Chr Location
    19p13.3; chr19:589893-617159 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 8 alleles in 8 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutant alleles exhibit decreased body weight, behavioral/neurological abnormalities, and tremors or absence seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15166 NCBI Gene Model | MGI Sequence Detail 19475 C57BL/6J ±  kb
    transcript NM_008226 RefSeq | MGI Sequence Detail 3195 Not Specified  
    polypeptide O88703 UniProt | EBI | MGI Sequence Detail 863 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3582956
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257405 Fisher DW, et al., Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice. PLoS One. 2018;13(2):e0193012

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory