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Hcn2
Gene Detail
Symbol

Name
ID
Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
MGI:1298210
Synonyms
HAC1, trls
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79716634-79736108 bp, + strand
From VEGA annotation of GRCm38

  19475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HCN2
Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn2

Human
homologs
HCN2, hyperpolarization activated cyclic nucleotide gated potassium channel 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 610
neXtProt AC: NX_Q9UL51

Human Synonyms: BCNG2, BCNG-2, HAC-1

Human Chr (Location): 19p13.3; chr19:589893-617159 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for mutant alleles exhibit decreased body weight, behavioral/neurological abnormalities, and tremors or absence seizures.
 
Interactions
Hcn2 interacts with 63 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process cellular response to cAMP, cellular response to cGMP, ...
Component axon, cytoplasm, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (9)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Western blot 2
RT-PCR 13
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase hcn2 ; ZFIN hcn2b    NEW 
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027869 (Evidence)
Ensembl Gene Model ENSMUSG00000020331 (Evidence)
Entrez Gene 15166 (Evidence)
UniGene 12956
DFCI TC1584738
DoTS DT.60104577, DT.110628867
NIA Mouse Gene Index U011721
PDB 3ETQ, 2Q0A, 3BPZ, 1Q5O, 1Q3E, 4EQF, 3FFQ, 1Q43
Consensus CDS Project CCDS23986.1
International Mouse Phenotyping Consortium Status Hcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027869 VEGA Gene Model | MGI Sequence Detail 19475 C57BL/6J ±  kb
transcript OTTMUST00000068991 VEGA | MGI Sequence Detail 3195 Not Applicable 
polypeptide OTTMUSP00000034995 VEGA | MGI Sequence Detail 863 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
References
(Earliest) J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(55)
Other
accession IDs
MGI:3582956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory