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Hcn2
Gene Detail
 Symbol
Name
ID
Hcn2
hyperpolarization-activated, cyclic nucleotide-gated K+ 2
MGI:1298210
Synonyms HAC1, trls
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79716634-79736108 bp, + strand
From VEGA annotation of GRCm38

  19475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn2

Human
homologs
Human Homolog HCN2, hyperpolarization activated cyclic nucleotide-gated potassium channel 2
NCBI Gene ID 610
neXtProt AC  NX_Q9UL51
Human Synonyms  BCNG2, BCNG-2, HAC-1
Human Chr (Location)  19p13.3; chr19:589893-617159 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Spontaneous(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutant alleles exhibit decreased body weight, behavioral/neurological abnormalities, and tremors or absence seizures.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cellular response to cAMP, cellular response to cGMP, ...
Component axon, dendritic shaft, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (7)    Images (9)
Theiler Stages: 23, 25, 28
Assay TypeResults
RNA in situ 9
Western blot 2
RT-PCR 13
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027869 (Evidence)
Ensembl Gene ModelENSMUSG00000020331 (Evidence)
Entrez Gene15166 (Evidence)
UniGene12956
DFCITC1584738
DoTSDT.110628867, DT.60104577
NIA Mouse Gene IndexU011721
PDB1Q3E, 1Q5O, 2Q0A, 3BPZ, 3ETQ, 3FFQ, 4EQF, 1Q43
Consensus CDS ProjectCCDS23986.1
International Mouse Knockout Project StatusHcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027869 VEGA Gene Model | MGI Sequence Detail 19475 C57BL/6J ±  kb
transcript OTTMUST00000068991 VEGA | MGI Sequence Detail 3195 Not Applicable 
polypeptide OTTMUSP00000034995 VEGA | MGI Sequence Detail 863 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
References (Earliest) J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
(Latest) J:207243 Carlson AE, et al., Flavonoid regulation of HCN2 channels. J Biol Chem. 2013 Nov 15;288(46):33136-45
All references(55)
Other
accession IDs
MGI:3582956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory