Sequence Detail

ID/Version

O88703 O70506 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;AltName: Full=Brain cyclic nucleotide-gated channel 2; Short=BCNG-2;AltName: Full=Hyperpolarization-activated cation channel 1; Short=HAC-1;

Provider

SWISS-PROT

Sequence

Polypeptide 863 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hcn2	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	79	111	3	21

Sequence references in MGI

J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
J:48083 Ludwig A, et al., A family of hyperpolarization-activated mammalian cation channels. Nature. 1998 Jun 11;393(6685):587-91
J:81398 Ludwig A, et al., Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15;22(2):216-24
J:176663 Emery EC, et al., HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science. 2011 Sep 9;333(6048):1462-6
J:184786 Bankston JR, et al., Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7899-904
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:314074 Zagotta WN, et al., Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature. 2003 Sep 11;425(6954):200-5
J:383810 Wainger BJ, et al., Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 2001 Jun 14;411(6839):805-10
J:384280 Chen J, et al., Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel. J Biol Chem. 2000 Nov 17;275(46):36465-71
J:384288 Zong X, et al., A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2. J Biol Chem. 2001 Mar 2;276(9):6313-9
J:384334 Proenza C, et al., Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. J Biol Chem. 2002 Aug 16;277(33):29634-42
J:384345 Tran N, et al., A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. J Biol Chem. 2002 Nov 15;277(46):43588-92
J:384389 Much B, et al., Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem. 2003 Oct 31;278(44):43781-6
J:384476 Flynn GE, et al., Structure and rearrangements in the carboxy-terminal region of SpIH channels. Structure. 2007 Jun;15(6):671-82
J:384710 Xu X, et al., Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel. Structure. 2012 Dec 5;20(12):2116-23