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Itgb2l Gene Detail
Summary
  • Symbol
    Itgb2l
  • Name
    integrin beta 2-like
  • Synonyms
    5033406G21Rik, pactolus
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277979
    NCBI Gene: 16415
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96223488-96244819 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.95 cM, cytoband C6
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277979
 protein coding gene Chr16:96223488-96244861 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023086
 protein coding gene Chr16:97802650-97825219 (-)
A/J MGP_AJ_G0023054
 protein coding gene Chr16:93173946-93195270 (-)
AKR/J MGP_AKRJ_G0023024
 protein coding gene Chr16:96037805-96059124 (-)
BALB/cJ MGP_BALBcJ_G0023056
 protein coding gene Chr16:93724521-93745841 (-)
C3H/HeJ MGP_C3HHeJ_G0022817
 protein coding gene Chr16:96566891-96588211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023503
 protein coding gene Chr16:100902376-100923697 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021005
 protein coding gene Chr16:91015780-91037460 (-)
CAST/EiJ MGP_CASTEiJ_G0022337
 protein coding gene Chr16:97365804-97387153 (-)
CBA/J MGP_CBAJ_G0022786
 protein coding gene Chr16:105259638-105280965 (-)
DBA/2J MGP_DBA2J_G0022920
 protein coding gene Chr16:93048778-93070886 (-)
FVB/NJ MGP_FVBNJ_G0022894
 protein coding gene Chr16:92221915-92243236 (-)
LP/J MGP_LPJ_G0022990
 protein coding gene Chr16:97442762-97464052 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022915
 protein coding gene Chr16:109475609-109496934 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023521
 protein coding gene Chr16:96574022-96595352 (-)
PWK/PhJ MGP_PWKPhJ_G0022081
 protein coding gene Chr16:93341665-93363653 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021911
 protein coding gene Chr16:96115235-96136142 (-)
WSB/EiJ MGP_WSBEiJ_G0022387
 protein coding gene Chr16:96843144-96864492 (-)



Homology
more
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Synonyms
    CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
  • Links
    NCBI Gene ID: 3689
    neXtProt AC: NX_P05107
    UniProt: P05107

  • Chr Location
    21q22.3; chr21:44885953-44931989 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ITGB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    89 phenotype references
Mice homozygous for a null allele display normal leukocyte development and normal neutrophil recruitment to inflamed tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000157 Ensembl Gene Model | MGI Sequence Detail 21332 C57BL/6J ±  kb
transcript ENSMUST00000113773 Ensembl | MGI Sequence Detail 2806 Not Applicable  
polypeptide ENSMUSP00000109403 Ensembl | MGI Sequence Detail 795 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 4
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923228
References
more
  • Summaries
    All 115
    Diseases 6
    Gene Ontology 5
    Phenotypes 89
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory