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Ptrf
Gene Detail
Symbol

Name
ID
Ptrf
polymerase I and transcript release factor
MGI:1277968
Synonyms
2310075E07Rik, Cavin, cavin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:100956733-100970887 bp, - strand
From VEGA annotation of GRCm38

  14155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ptrf

Human
homologs
Human Homolog PTRF, polymerase I and transcript release factor
NCBI Gene ID 284119
neXtProt AC  NX_Q6NZI2
Human Synonyms  CAVIN, cavin-1, CAVIN1, CGL4
Human Chr (Location)  17q21.2; chr17:42402449-42423320 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTRF
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit the absence of calveolae, dyslipidemia, and glucose intolerance.
 
Human Diseases Modeled Using Mouse Ptrf (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ptrf interacts with 194 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process DNA-templated transcription, termination, regulation of transcription, DNA-templated, ...
Component caveola, cytoplasm, ...
Function poly(A) RNA binding, RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (51)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
RT-PCR 2
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002126 (Evidence)
Ensembl Gene ModelENSMUSG00000004044 (Evidence)
Entrez Gene19285 (Evidence)
UniGene21864
DFCITC1661494, TC1576169
DoTSDT.99858555, DT.91338361, DT.99858556
NIA Mouse Gene IndexU033440
Consensus CDS ProjectCCDS25442.1
International Mouse Knockout Project StatusPtrf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002126 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000004316 VEGA | MGI Sequence Detail 3491 Not Applicable 
polypeptide OTTMUSP00000002049 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026752 Cavin family
Protein Ontology PR:000013483 polymerase I and transcript release factor
References
(Earliest) J:48217 Jansa P, et al., Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998 May 15;17(10):2855-64
(Latest) J:211204 Ding SY, et al., Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21;289(12):8473-83
All references(50)
Disease annotation references (1)
Other
accession IDs
MGI:1916919, MGI:2144560

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory