Ptrf
Gene Detail

Symbol Name ID

Ptrf polymerase I and transcript release factor MGI:1277968

Synonyms

2310075E07Rik, Cavin

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:100956733-100970887 bp, - strand From VEGA annotation of GRCm38   14155 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ptrf

Human homologs

Human Homolog		PTRF, polymerase I and transcript release factor
NCBI Gene ID		284119
neXtProt AC		NX_Q6NZI2
Human Synonyms		CAVIN, cavin-1, CAVIN1, CGL4
Human Chr (Location)		17q21.2; chr17:40554467-40575338 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTRF

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)
 

Mice homozygous for a null allele exhibit the absence of calveolae, dyslipidemia, and glucose intolerance.

 
Human Diseases Modeled Using Mouse Ptrf (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	DNA-dependent transcription, termination, regulation of transcription, DNA-dependent, ...
Component	caveola, cytoplasm, ...
Function	RNA binding, rRNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (51)    Images (5)
Theiler Stages: 11, 15, 17, 21, 23, 28

Assay Type	Results
RNA in situ	57
RT-PCR	2

cDNA source data(92)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000002126 (Evidence)
Ensembl Gene Model	ENSMUSG00000004044 (Evidence)
Entrez Gene	19285 (Evidence)
UniGene	21864
DFCI	TC1576169, TC1661494
DoTS	DT.91338361, DT.99858555, DT.99858556
NIA Mouse Gene Index	U033440
Consensus CDS Project	CCDS25442.1
International Mouse Knockout Project Status	Ptrf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002126	VEGA Gene Model | MGI Sequence Detail	14155	C57BL/6J
transcript	OTTMUST00000004316	VEGA | MGI Sequence Detail	3491	Not Applicable
polypeptide	OTTMUSP00000002049	VEGA | MGI Sequence Detail	392	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026752	Cavin family
Protein Ontology	PR:000013483	polymerase I and transcript release factor

References

(Earliest) J:48217 Jansa P, et al., Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998 May 15;17(10):2855-64
(Latest) J:186939 Tkachenko E, et al., Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. PLoS One. 2012;7(3):e32655
All references(45)

Other accession IDs

MGI:1916919, MGI:2144560