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Ptrf
Gene Detail
Symbol

Name
ID
Ptrf
polymerase I and transcript release factor
MGI:1277968
Synonyms
2310075E07Rik, Cavin, cavin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:100956733-100970887 bp, - strand
From VEGA annotation of GRCm38

  14155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7499  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTRF
Gene Tree: Ptrf

Human
homologs
PTRF, polymerase I and transcript release factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 284119
neXtProt AC: NX_Q6NZI2

Human Synonyms: CAVIN, cavin-1, CAVIN1, CGL4, FKSG13

Human Chr (Location): 17q21.2; chr17:42402449-42423320 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTRF

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Genomic Mutations involving Ptrf (1)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit the absence of calveolae, dyslipidemia, and glucose intolerance, pulmonary arterial hypertension, and urinary bladder abnormalities.
 
Human Diseases Modeled in Mice Using Ptrf (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ptrf interacts with 194 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process DNA-templated transcription, termination, regulation of transcription, DNA-templated, ...
Component caveola, cytoplasm, ...
Function poly(A) RNA binding, RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (51)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
RT-PCR 2
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptrf ; ZFIN ptrfb    NEW 
Molecular
reagents
All nucleic(99) cDNA(98) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000002126 (Evidence)
Ensembl Gene Model ENSMUSG00000004044 (Evidence)
Entrez Gene 19285 (Evidence)
UniGene 21864
DFCI TC1661494, TC1576169
DoTS DT.99858555, DT.91338361, DT.99858556
NIA Mouse Gene Index U033440
PDB 4QKV
Consensus CDS Project CCDS25442.1
International Mouse Phenotyping Consortium Status Ptrf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002126 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000004316 VEGA | MGI Sequence Detail 3491 Not Applicable 
polypeptide OTTMUSP00000002049 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026752 Cavin family
Protein Ontology PR:000013483 polymerase I and transcript release factor
References
(Earliest) J:48217 Jansa P, et al., Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998 May 15;17(10):2855-64
(Latest) J:220363 Wei Z, et al., The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association. Biochem Biophys Res Commun. 2015 Jan 16;456(3):750-6
All references(54)
Disease annotation references (1)
Other
accession IDs
MGI:1916919, MGI:2144560

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory