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Kcnn4 Gene Detail
Summary
  • Symbol
    Kcnn4
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
  • Synonyms
    IK1, IKCa1, KCa3.1, mIKCa1, SK4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277957
    NCBI Gene: 16534
  • Gene Overview
    MyGene.info: KCNN4
Location & Maps
more
  • Sequence Map
    Chr7:24370263-24386690 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 10.37 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    KCNN4, potassium calcium-activated channel subfamily N member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNN4, potassium calcium-activated channel subfamily N member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DHS2, hIKCa1, hKCa4, hSK4, IK, IK1, IKCA1, KCa3.1, KCA4, SK4
  • Links
    NCBI Gene ID: 3783
    neXtProt AC: NX_O15554

  • Chr Location
    19q13.2; chr19:43766533-43782139 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KCNN4 associations

Human Disease Mouse Models
       Dehydrated Hereditary Stomatocytosis 2; DHS2   OMIM: 616689
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice have increased parotid gland weight and both sexes have impaired volume regulation in erythrocytes and T lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058076 VEGA Gene Model | MGI Sequence Detail 16428 C57BL/6J ±  kb
transcript OTTMUST00000142592 VEGA | MGI Sequence Detail 1945 Not Applicable  
polypeptide OTTMUSP00000074379 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    202 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
Molecular
Reagents
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  • All nucleic 243
    cDNA 239
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 68
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 28
  • Earliest
    J:49276 Vandorpe DH, et al., cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21;273(34):21542-53
  • Latest
    J:230847 Mattheij NJ, et al., Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. FASEB J. 2016 Feb;30(2):727-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory