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Kcnn4
Gene Detail
Symbol

Name
ID
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
MGI:1277957
Synonyms
IK1, IKCa1, KCa3.1, mIKCa1, SK4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
10.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:24370263-24385209 bp, + strand
From Ensembl annotation of GRCm38

  14947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNN4
Protein SuperFamily: small/intermediate conductance calcium-activated potassium channel protein
Gene Tree: Kcnn4

Human
homologs
KCNN4, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3783
neXtProt AC: NX_O15554

Human Synonyms: hIKCa1, hKCa4, hSK4, IK, IK1, IKCA1, KCa3.1, KCA4, SK4

Human Chr (Location): 19q13.2; chr19:43766533-43782139 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null male mice have increased parotid gland weight and both sexes have impaired volume regulation in erythrocytes and T lymphocytes.
 
Interactions
Kcnn4 interacts with 84 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anion transport, calcium ion transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function calcium-activated potassium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (196)    Tissues (131)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 3
cDNA source data(239)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(243) cDNA(239) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000054342 (Evidence)
Entrez Gene 16534 (Evidence)
UniGene 9911
DFCI TC1681805, TC1624856, TC1605977, TC1572747
DoTS DT.101717966, DT.101283223, DT.491549, DT.94216605, DT.94216600, DT.91429608
NIA Mouse Gene Index U007794
Consensus CDS Project CCDS20948.1
International Mouse Phenotyping Consortium Status Kcnn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054342 Ensembl Gene Model | MGI Sequence Detail 14947 C57BL/6J ±  kb
transcript ENSMUST00000171904 Ensembl | MGI Sequence Detail 2034 Not Applicable 
polypeptide ENSMUSP00000133065 Ensembl | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004178 Calmodulin-binding domain
InterPro IPR013099 Ion transport 2
InterPro IPR015449 Potassium channel, calcium-activated, SK
Protein Ontology PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
References
(Earliest) J:49276 Vandorpe DH, et al., cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21;273(34):21542-53
(Latest) J:216315 Wandall-Frostholm C, et al., Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels. PLoS One. 2014;9(5):e97687
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory