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Kcnn4
Gene Detail
Symbol

Name
ID
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
MGI:1277957
Synonyms
IK1, IKCa1, KCa3.1, mIKCa1, SK4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
10.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:24370263-24385209 bp, + strand
From Ensembl annotation of GRCm38

  14947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small/intermediate conductance calcium-activated potassium channel protein
Gene Tree: Kcnn4

Human
homologs
Human Homolog KCNN4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
NCBI Gene ID 3783
neXtProt AC  NX_O15554
Human Synonyms  hIKCa1, hKCa4, hSK4, IK1, IKCA1, KCa3.1, KCA4, SK4
Human Chr (Location)  19q13.2; chr19:43766533-43782117 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null male mice have increased parotid gland weight and both sexes have impaired volume regulation in erythrocytes and T lymphocytes.
 
Interactions
Kcnn4 interacts with 84 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anion transport, calcium ion transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function calcium-activated potassium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (196)    Tissues (131)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 3
cDNA source data(239)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(243) cDNA(239) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054342 (Evidence)
Entrez Gene16534 (Evidence)
UniGene9911
DFCITC1624856, TC1605977, TC1681805, TC1572747
DoTSDT.101717966, DT.101283223, DT.491549, DT.91429608, DT.94216600, DT.94216605
NIA Mouse Gene IndexU007794
Consensus CDS ProjectCCDS20948.1
International Mouse Knockout Project StatusKcnn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054342 Ensembl Gene Model | MGI Sequence Detail 14947 C57BL/6J ±  kb
transcript ENSMUST00000171904 Ensembl | MGI Sequence Detail 2034 Not Applicable 
polypeptide ENSMUSP00000133065 Ensembl | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004178 Calmodulin-binding domain
InterPro IPR013099 Ion transport 2
InterPro IPR015449 Potassium channel, calcium-activated, SK
Protein Ontology PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
References
(Earliest) J:49276 Vandorpe DH, et al., cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21;273(34):21542-53
(Latest) J:213665 Yu Z, et al., Targeted inhibition of KCa3.1 attenuates TGF-beta-induced reactive astrogliosis through the Smad2/3 signaling pathway. J Neurochem. 2014 Jul;130(1):41-9
All references(63)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory