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Tbx15
Gene Detail
 Symbol
Name
ID
Tbx15
T-box 15
MGI:1277234
Synonyms de, Tbx14, Tbx8
Feature Type protein coding gene
Genetic Map
Chromosome 3
43.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr3:99240381-99354259 bp, + strand
From VEGA annotation of GRCm38

  113879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7967  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tbx15

Human
homologs
Human Homolog TBX15, T-box 15
NCBI Gene ID 6913
neXtProt AC  NX_Q96SF7
Human Synonyms  TBX14
Human Chr (Location)  1p11.1; chr1:118883043-118989556 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TBX15
Alleles
and
phenotypes
All alleles(6) : Targeted(4) Spontaneous(2)
 
Homozygous mutants have low set ears that project laterally, skeletal abnormalities and distinctive dorsoventral coat color patterning.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process embryonic cranial skeleton morphogenesis, embryonic skeletal system morphogenesis, ...
Component nucleus, Tle3-Aes complex
Function DNA binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (164)    Tissues (86)    Images (30)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 145
Northern blot 4
RT-PCR 15
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006867 (Evidence)
Ensembl Gene ModelENSMUSG00000027868 (Evidence)
Entrez Gene21384 (Evidence)
UniGene88761
DFCITC1583965
DoTSDT.101159654, DT.111061293, DT.111061302, DT.50315684
NIA Mouse Gene IndexU003629
Consensus CDS ProjectCCDS17673.1
International Mouse Knockout Project StatusTbx15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006867 VEGA Gene Model | MGI Sequence Detail 113879 C57BL/6J ±  kb
transcript OTTMUST00000015869 VEGA | MGI Sequence Detail 3566 Not Applicable 
polypeptide OTTMUSP00000007288 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(845 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR001699 Transcription factor, T-box
InterPro IPR018186 Transcription factor, T-box, conserved site
Protein Ontology PR:000016145 T-box transcription factor TBX15
References (Earliest) J:65329 Falconer DS, de - droopy ear. Mouse News Lett. 1955;12:20
(Latest) J:189879 Gburcik V, et al., An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1053-60
All references(53)
Other
accession IDs
MGD-MRK-8821, MGI:1201668, MGI:94879

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory