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Tbx15 Gene Detail
Summary
  • Symbol
    Tbx15
  • Name
    T-box 15
  • Synonyms
    de, Tbx14, Tbx8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277234
    NCBI Gene: 21384
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:99240381-99354259 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 43.03 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    840 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277234
protein coding gene Chr3:99240349-99354260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027663
protein coding gene Chr3:100319829-100442100 (+)
A/J MGP_AJ_G0027622
protein coding gene Chr3:97110257-97225210 (+)
AKR/J MGP_AKRJ_G0027588
protein coding gene Chr3:99457453-99580390 (+)
BALB/cJ MGP_BALBcJ_G0027635
protein coding gene Chr3:96918844-97038406 (+)
C3H/HeJ MGP_C3HHeJ_G0027364
protein coding gene Chr3:99799734-99913409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028078
protein coding gene Chr3:104000189-104129143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025419
protein coding gene Chr3:93403745-93517300 (+)
CAST/EiJ MGP_CASTEiJ_G0026820
protein coding gene Chr3:98933253-99054996 (+)
CBA/J MGP_CBAJ_G0027339
protein coding gene Chr3:107705662-107821667 (+)
DBA/2J MGP_DBA2J_G0027482
protein coding gene Chr3:96394440-96508854 (+)
FVB/NJ MGP_FVBNJ_G0027450
protein coding gene Chr3:94337856-94452445 (+)
LP/J MGP_LPJ_G0027589
protein coding gene Chr3:101684450-101799558 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027480
protein coding gene Chr3:113825975-113931895 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028133
protein coding gene Chr3:99012462-99130219 (+)
PWK/PhJ MGP_PWKPhJ_G0026547
protein coding gene Chr3:96163533-96305149 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026369
protein coding gene Chr3:97113677-97228941 (+)
WSB/EiJ MGP_WSBEiJ_G0026900
protein coding gene Chr3:99566102-99687813 (+)



Homology
more
  • Human Ortholog
    TBX15, T-box 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBX15, T-box 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TBX14
  • Links
    NCBI Gene ID: 6913
    neXtProt AC: NX_Q96SF7
    UniProt: Q96SF7

  • Chr Location
    1p12; chr1:118883043-118989556 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7967
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TBX15
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants have low set ears that project laterally, skeletal abnormalities and distinctive dorsoventral coat color patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027868 Ensembl Gene Model | MGI Sequence Detail 113879 C57BL/6J ±  kb
    transcript ENSMUST00000029462 Ensembl | MGI Sequence Detail 3566 Not Applicable  
    polypeptide ENSMUSP00000029462 Ensembl | MGI Sequence Detail 602 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 24
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-8821, MGI:1201668, MGI:94879
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:233 Curry GA, Genetical and development studies on droopy-eared mice. J Embryol Exp Morphol. 1959 Mar;7(1):39-65
    • Latest
      J:263025 Zoupa M, et al., Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory