Tbx15
Gene Detail

Symbol Name ID

Tbx15 T-box 15 MGI:1277234

Synonyms

de, Tbx14, Tbx8

Feature Type

protein coding gene

Genetic Map

Chromosome 3

43.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr3:99240381-99354259 bp, + strand From VEGA annotation of GRCm38   113879 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7967  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tbx15

Human homologs

Human Homolog		TBX15, T-box 15
NCBI Gene ID		6913
neXtProt AC		NX_Q96SF7
Human Synonyms		TBX14
Human Chr (Location)		1p11.1; chr1:119425666-119532179 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TBX15

Alleles and phenotypes

All alleles(6) : Targeted(4) Spontaneous(1) Other(1)
 

Homozygous mutants have low set ears that project laterally, skeletal abnormalities and distinctive dorsoventral coat color patterning.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	embryonic cranial skeleton morphogenesis, embryonic skeletal system morphogenesis, ...
Component	nucleus, Tle3-Aes complex
Function	DNA binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (164)    Tissues (86)    Images (30)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	145
Northern blot	4
RT-PCR	15

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006867 (Evidence)
Ensembl Gene Model	ENSMUSG00000027868 (Evidence)
Entrez Gene	21384 (Evidence)
UniGene	88761
DFCI	TC1583965
DoTS	DT.101159654, DT.111061293, DT.111061302, DT.50315684
NIA Mouse Gene Index	U003629
Consensus CDS Project	CCDS17673.1
International Mouse Knockout Project Status	Tbx15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006867	VEGA Gene Model | MGI Sequence Detail	113879	C57BL/6J
transcript	OTTMUST00000015869	VEGA | MGI Sequence Detail	3566	Not Applicable
polypeptide	OTTMUSP00000007288	VEGA | MGI Sequence Detail	602	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(566 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR001699	Transcription factor, T-box
InterPro	IPR018186	Transcription factor, T-box, conserved site
Protein Ontology	PR:000016145	T-box transcription factor TBX15

References

(Earliest) J:65329 Falconer DS, de - droopy ear. Mouse News Lett. 1955;12:20
(Latest) J:189879 Gburcik V, et al., An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1053-60
All references(53)

Other accession IDs

MGD-MRK-8821, MGI:1201668, MGI:94879