Tbx15 MGI Mouse Gene Detail - MGI:1277234

Symbol

Tbx15
Name

T-box 15
Synonyms

de, Tbx14, Tbx8

Feature Type

protein coding gene
IDs

MGI:1277234
NCBI Gene: 21384
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:99147697-99261575 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.03 cM
Mapping Data

10 experiments

SNPs within 2kb

2828 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277234	protein coding gene	Chr3:99147671-99261576 (+)
129S1/SvImJ	ENSMUSG00200044102	protein coding gene	Chr3:95755904-95869839 (+)
A/J	ENSMUSG00195047892	protein coding gene	Chr3:96126108-96239911 (+)
AKR/J	ENSMUSG00220038707	protein coding gene	Chr3:94493294-94608617 (+)
BALB/cJ	ENSMUSG00180038625	protein coding gene	Chr3:96068525-96182340 (+)
C3H/HeJ	ENSMUSG00175022946	protein coding gene	Chr3:95689659-95803464 (+)
C57BL/6NJ	ENSMUSG00215014834	protein coding gene	Chr3:96405022-96518977 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025419	protein coding gene	Chr3:93403745-93517300 (+)
CAST/EiJ	ENSTCUG00005018066	protein coding gene	Chr3:96363870-96478670 (+)
CBA/J	ENSMUSG00210050758	protein coding gene	Chr3:96237259-96351058 (+)
DBA/2J	ENSMUSG00185036068	protein coding gene	Chr3:96720670-96834529 (+)
FVB/NJ	ENSMUSG00205015076	protein coding gene	Chr3:95330172-95444122 (+)
JF1/MsJ	ENSUMUG00000029520	protein coding gene	Chr3:95461745-95576913 (+)
LP/J	ENSMUSG00230040449	protein coding gene	Chr3:98684194-98798139 (+)
NOD/ShiLtJ	ENSMUSG00190028010	protein coding gene	Chr3:96889776-97005859 (+)
NZO/HlLtJ	ENSMUSG00225009467	protein coding gene	Chr3:101097684-101211547 (+)
PWK/PhJ	ENSLUMG00010027478	protein coding gene	Chr3:95555005-95669958 (+)
SPRET/EiJ	ENSMSPG00010041639	protein coding gene	Chr3:95720898-95850802 (+)
WSB/EiJ	ENSIUOG00005028726	protein coding gene	Chr3:96244617-96366447 (+)

Human Ortholog

TBX15, T-box transcription factor 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBX15, T-box transcription factor 15
Synonyms

TBX14
Links

HGNC:11594

NCBI Gene ID: 6913

UniProt: Q96SF7
Chr Location

1p12; chr1:118883046-118989556 (-) GRCh38

MGI Vertebrate Homology

Tbx15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBX15
Gene Tree

Tbx15

less

References

1 with disease annotations

less

Phenotype Summary

60 phenotypes from 4 alleles in 4 genetic backgrounds
19 phenotypes from multigenic genotypes
2 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Spontaneous

2
Targeted

5
Genomic Mutations

2 involving Tbx15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants have low set ears that project laterally, skeletal abnormalities and distinctive dorsoventral coat color patterning.

less

All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

131
cDNA Data

25
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TBX15

Xenbase tbx15

ZFIN tbx15

less

All Sequences

44
RefSeq

8
UniProt

3
CCDS

CCDS17673.1

Ensembl

ENSMUSG00000027868 (Evidence)
NCBI Gene

21384

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027868	Ensembl Gene Model \| MGI Sequence Detail	113879	C57BL/6J	± kb
transcript	ENSMUST00000029462	Ensembl \| MGI Sequence Detail	3566	Not Applicable
polypeptide	ENSMUSP00000029462	Ensembl \| MGI Sequence Detail	602	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000016145 T-box transcription factor TBX15

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR036960 T-box superfamily

IPR001699 T-box transcription factor

IPR046360 T-box transcription factor, DNA-binding domain

IPR018186 Transcription factor, T-box, conserved site
GlyGen

O70306 1 site

less

All nucleic 33

Genomic 1

cDNA 25

Primer pair 5

Other 2

Antibodies 1

Microarray probesets 6

less

MGD-MRK-8821, MGI:1201668, MGI:94879

Summaries

All 81

Developmental Gene Expression 34

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:233 Curry GA, Genetical and development studies on droopy-eared mice. J Embryol Exp Morphol. 1959 Mar;7(1):39-65
Latest

J:382984 Wang B, et al., Persistent Wnt/beta-catenin signaling disables soft palatogenesis and palatal osteogenesis by inducing mesenchymal condensation. Front Cell Dev Biol. 2026;14:1740081

TSS for Tbx15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30857	Chr3:99147644-99147653 (+)	-48 bp
Tssr30858	Chr3:99147677-99147701 (+)	-8 bp
Tssr30859	Chr3:99160649-99160661 (+)	12,958 bp
Tssr30860	Chr3:99160662-99160699 (+)	12,984 bp
Tssr30861	Chr3:99161070-99161123 (+)	13,400 bp
Tssr30862	Chr3:99203818-99203829 (+)	56,127 bp
Tssr30863	Chr3:99203836-99203847 (+)	56,145 bp
Tssr982	Chr3:99203861-99203870 (+)	56,169 bp
Tssr30864	Chr3:99223804-99223819 (+)	76,115 bp
Tssr30865	Chr3:99259990-99260005 (+)	112,301 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24