Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic cranial skeleton morphogenesis. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; facial prominence; genitourinary system; limb; and limb bud. Orthologous to human TBX15 (T-box transcription factor 15).