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Rpap3 Gene Detail
Summary
  • Symbol
    Rpap3
  • Name
    RNA polymerase II associated protein 3
  • Synonyms
    2310042P20Rik, D15Ertd682e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277218
    NCBI Gene: 71919
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97572978-97603706 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 53.54 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277218
protein coding gene Chr15:97572978-97603746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022276
protein coding gene Chr15:99344276-99375777 (-)
A/J MGP_AJ_G0022235
protein coding gene Chr15:95414119-95445434 (-)
AKR/J MGP_AKRJ_G0022210
protein coding gene Chr15:98292478-98324845 (-)
BALB/cJ MGP_BALBcJ_G0022241
protein coding gene Chr15:95639410-95671181 (-)
C3H/HeJ MGP_C3HHeJ_G0022011
protein coding gene Chr15:98371725-98402316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022686
protein coding gene Chr15:103009133-103043589 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020212
protein coding gene Chr15:91361202-91393203 (-)
CAST/EiJ MGP_CASTEiJ_G0021533
protein coding gene Chr15:99245430-99276679 (-)
CBA/J MGP_CBAJ_G0021978
protein coding gene Chr15:106473088-106506991 (-)
DBA/2J MGP_DBA2J_G0022105
protein coding gene Chr15:94866994-94898020 (-)
FVB/NJ MGP_FVBNJ_G0022084
protein coding gene Chr15:93855292-93885929 (-)
LP/J MGP_LPJ_G0022176
protein coding gene Chr15:99449460-99483384 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022104
protein coding gene Chr15:110595093-110629088 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022701
protein coding gene Chr15:98446389-98478560 (-)
PWK/PhJ MGP_PWKPhJ_G0021274
protein coding gene Chr15:94964209-94995161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021108
protein coding gene Chr15:98216839-98250032 (-)
WSB/EiJ MGP_WSBEiJ_G0021582
protein coding gene Chr15:98963909-98997334 (-)



Homology
more
  • Human Ortholog
    RPAP3, RNA polymerase II associated protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPAP3, RNA polymerase II associated protein 3
  • Synonyms
    hSpagh, Tah1
  • Links
    NCBI Gene ID: 79657
    neXtProt AC: NX_Q9H6T3
    UniProt: Q9H6T3

  • Chr Location
    12q13.11; chr12:47661932-47706061 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in epithelial cells exhibit impaired proliferation and increased apoptosis in the small intestine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022466 Ensembl Gene Model | MGI Sequence Detail 30729 C57BL/6J ±  kb
    transcript ENSMUST00000023104 Ensembl | MGI Sequence Detail 2271 Not Applicable  
    polypeptide ENSMUSP00000023104 Ensembl | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000014177 RNA polymerase II-associated protein 3
    • InterPro Domains
      IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001440 Tetratricopeptide repeat 1
    Molecular
    Reagents
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    • All nucleic 58
      cDNA 57
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919169
    References
    more
    • Summaries
      All 55
      Diseases 1
      Gene Ontology 2
      Phenotypes 30
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:314346 Maurizy C, et al., The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021 Aug 10;12(1):4810

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/22/2022
    MGI 6.21
    The Jackson Laboratory