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Dcx Gene Detail
Summary
  • Symbol
    Dcx
  • Name
    doublecortin
  • Synonyms
    Dbct, lissencephaly, X-linked (doublecortin)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277171
    NCBI Gene: 13193
  • Gene Overview
    MyGene.info: DCX
Location & Maps
more
  • Sequence Map
    ChrX:143855842-143933311 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      77470 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DCX, doublecortin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DCX, doublecortin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DBCN, DC, LISX, SCLH, XLIS
  • Links
    NCBI Gene ID: 1641
    neXtProt AC: NX_O43602

  • Chr Location
    Xq22.3-q23; chrX:111293779-111412232 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dcx mouse models; 1 with human DCX associations

Human Disease Mouse Models
       Lissencephaly 1; LIS1   OMIM: 607432 View 1 model
       Lissencephaly, X-Linked, 1; LISX1   OMIM: 300067
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    42 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018842 VEGA Gene Model | MGI Sequence Detail 77470 C57BL/6J ±  kb
transcript OTTMUST00000045335 VEGA | MGI Sequence Detail 9074 Not Applicable  
polypeptide OTTMUSP00000020394 VEGA | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    378 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006335 neuronal migration protein doublecortin
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR003533 Doublecortin domain
    IPR017302 Neuronal migration protein doublecortin, chordata
Molecular
Reagents
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  • All nucleic 214
    cDNA 206
    Primer pair 2
    Other 6

    Microarray probesets 6
References
more
  • Summaries
    All 246
    Developmental Gene Expression 194
    Diseases 1
    Gene Ontology 13
    Phenotypes 26
  • Earliest
    J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
  • Latest
    J:228347 Daviaud N, et al., Impaired cortical neurogenesis in Plexin-B1 and -B2 double deletion mutant. Dev Neurobiol. 2015 Nov 18;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory