About   Help   FAQ
Dcx
Gene Detail
Symbol

Name
ID
Dcx
doublecortin
MGI:1277171
Synonyms
Dbct, lissencephaly, X-linked (doublecortin)
Feature Type
protein coding gene
Genetic Map
Chromosome X
64.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:143855842-143933311 bp, - strand
From VEGA annotation of GRCm38

  77470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: DCX
Protein SuperFamily: neuronal migration protein doublecortin
Gene Tree: Dcx

Human
homologs
DCX, doublecortin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1641
neXtProt AC: NX_O43602

Human Synonyms: DBCN, DC, LISX, SCLH, XLIS

Human Chr (Location): Xq22.3-q23; chrX:111293779-111412232 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DCX

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.
 
Human Diseases Modeled in Mice Using Dcx (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dcx interacts with 557 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process axon extension, brain development, ...
Component cell projection, cytoplasm, ...
Function calcium-dependent protein serine/threonine kinase activity, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (174 records)
Data Summary: Results (475)    Tissues (220)    Images (101)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 66
RNA in situ 395
Northern blot 4
Western blot 10
cDNA source data(204)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DCX    NEW 
Molecular
reagents
All nucleic(214) cDNA(206) Primer pair(2) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018842 (Evidence)
Ensembl Gene Model ENSMUSG00000031285 (Evidence)
Entrez Gene 13193 (Evidence)
UniGene 12871
DFCI TC1602017, TC1591243, TC1583939, TC1616402, TC1644782, TC1629069
DoTS DT.87072353, DT.103562406, DT.101300145, DT.94180606, DT.91333045
NIA Mouse Gene Index U039758
Consensus CDS Project CCDS41157.1, CCDS53209.1, CCDS53210.1
International Mouse Phenotyping Consortium Status Dcx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018842 VEGA Gene Model | MGI Sequence Detail 77470 C57BL/6J ±  kb
transcript OTTMUST00000045335 VEGA | MGI Sequence Detail 9074 Not Applicable 
polypeptide OTTMUSP00000020394 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR003533 Doublecortin domain
InterPro IPR017302 Neuronal migration protein doublecortin, chordata
Protein Ontology PR:000006335 neuronal migration protein doublecortin
References
(Earliest) J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
(Latest) J:218049 Houlihan SL, et al., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297
All references(229)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory