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Dcx
Gene Detail
Symbol

Name
ID
Dcx
doublecortin
MGI:1277171
Synonyms
Dbct, lissencephaly, X-linked (doublecortin)
Feature Type
protein coding gene
Genetic Map
Chromosome X
64.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:143855842-143933311 bp, - strand
From VEGA annotation of GRCm38

  77470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: neuronal migration protein doublecortin
Gene Tree: Dcx

Human
homologs
Human Homolog DCX, doublecortin
NCBI Gene ID 1641
neXtProt AC  NX_O43602
Human Synonyms  DBCN, DC, LISX, SCLH, XLIS
Human Chr (Location)  Xq22.3-q23; chrX:111293779-111412232 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DCX
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.
 
Human Diseases Modeled Using Mouse Dcx (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dcx interacts with 558 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process axon extension, brain development, ...
Component cell projection, cytoplasm, ...
Function microtubule binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (167 records)
Data Summary: Results (475)    Tissues (220)    Images (100)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 65
RNA in situ 396
Northern blot 4
Western blot 10
cDNA source data(204)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(214) cDNA(206) Primer pair(2) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000018842 (Evidence)
Ensembl Gene ModelENSMUSG00000031285 (Evidence)
Entrez Gene13193 (Evidence)
UniGene12871
DFCITC1583939, TC1616402, TC1629069, TC1602017, TC1591243, TC1644782
DoTSDT.101300145, DT.103562406, DT.94180606, DT.91333045, DT.87072353
NIA Mouse Gene IndexU039758
Consensus CDS ProjectCCDS41157.1, CCDS53209.1, CCDS53210.1
International Mouse Knockout Project StatusDcx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018842 VEGA Gene Model | MGI Sequence Detail 77470 C57BL/6J ±  kb
transcript OTTMUST00000045335 VEGA | MGI Sequence Detail 9074 Not Applicable 
polypeptide OTTMUSP00000020394 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR003533 Doublecortin domain
InterPro IPR017302 Neuronal migration protein doublecortin, chordata
Protein Ontology PR:000006335 neuronal migration protein doublecortin
References
(Earliest) J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
(Latest) J:213573 Padmakumar V, et al., Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line. BMC Dev Biol. 2014;14:24
All references(219)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory