Dcx
Gene Detail

Symbol Name ID

Dcx doublecortin MGI:1277171

Synonyms

Dbct, lissencephaly, X-linked (doublecortin)

Feature Type

protein coding gene

Genetic Map

Chromosome X

64.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:143855842-143933311 bp, - strand From VEGA annotation of GRCm38   77470 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: neuronal migration protein doublecortin
Gene Tree: Dcx

Human homologs

Human Homolog		DCX, doublecortin
NCBI Gene ID		1641
neXtProt AC		NX_O43602
Human Synonyms		DBCN, DC, LISX, SCLH, XLIS
Human Chr (Location)		Xq22.3-q23; chrX:110537007-110655460 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DCX

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.

 
Human Diseases Modeled Using Mouse Dcx (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	axon extension, brain development, ...
Component	cell projection, cytoplasm, ...
Function	microtubule binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (138 records)
Data Summary: Results (403)    Tissues (180)    Images (58)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	378
Northern blot	4
Western blot	8

cDNA source data(204)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(212) cDNA(206) Primer pair(2) Other(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000018842 (Evidence)
Ensembl Gene Model	ENSMUSG00000031285 (Evidence)
Entrez Gene	13193 (Evidence)
UniGene	12871
DFCI	TC1583939, TC1591243, TC1602017, TC1616402, TC1629069, TC1644782
DoTS	DT.101300145, DT.103562406, DT.87072353, DT.91333045, DT.94180606
NIA Mouse Gene Index	U039758
Consensus CDS Project	CCDS41157.1, CCDS53209.1, CCDS53210.1
International Mouse Knockout Project Status	Dcx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018842	VEGA Gene Model | MGI Sequence Detail	77470	C57BL/6J
transcript	OTTMUST00000045335	VEGA | MGI Sequence Detail	9074	Not Applicable
polypeptide	OTTMUSP00000020394	VEGA | MGI Sequence Detail	366	Not Applicable

All sequences(68) RefSeq(8) UniProt(5)

Polymorphisms

SNPs(358 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003533	Doublecortin domain
InterPro	IPR017302	Neuronal migration protein doublecortin, chordata
Protein Ontology	PR:000006335	neuronal migration protein doublecortin

References

(Earliest) J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
(Latest) J:194076 Liang H, et al., Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013 Feb 1;140(3):552-61
All references(184)