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Dcx Gene Detail
Summary
  • Symbol
    Dcx
  • Name
    doublecortin
  • Synonyms
    Dbct, lissencephaly, X-linked (doublecortin)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277171
    NCBI Gene: 13193
  • Gene Overview
    MyGene.info: DCX
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:143855842-143933275 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 64.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277171
protein coding gene ChrX:143855842-143933311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036157
protein coding gene ChrX:141419535-141498334 (-)
A/J MGP_AJ_G0036134
protein coding gene ChrX:140743010-140826515 (-)
AKR/J MGP_AKRJ_G0036060
protein coding gene ChrX:145302705-145380818 (-)
BALB/cJ MGP_BALBcJ_G0036125
protein coding gene ChrX:138977802-139054170 (-)
C3H/HeJ MGP_C3HHeJ_G0035833
protein coding gene ChrX:141496263-141576556 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036648
protein coding gene ChrX:145366911-145466856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033472
protein coding gene ChrX:132270396-132348231 (-)
CAST/EiJ MGP_CASTEiJ_G0035124
protein coding gene ChrX:122191220-122270687 (-)
CBA/J MGP_CBAJ_G0035810
protein coding gene ChrX:149932119-150008489 (-)
DBA/2J MGP_DBA2J_G0035968
protein coding gene ChrX:139837704-139914348 (-)
FVB/NJ MGP_FVBNJ_G0035902
protein coding gene ChrX:139032234-139110034 (-)
LP/J MGP_LPJ_G0036059
protein coding gene ChrX:142360576-142434732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035938
protein coding gene ChrX:157648148-157731997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036685
protein coding gene ChrX:140714528-140798990 (-)
PWK/PhJ MGP_PWKPhJ_G0034818
protein coding gene ChrX:118984938-119064114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034643
protein coding gene ChrX:122738609-122819939 (-)
WSB/EiJ MGP_WSBEiJ_G0035259
protein coding gene ChrX:139074066-139152117 (-)



Homology
more
  • Human Ortholog
    DCX, doublecortin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DCX, doublecortin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBCN, DC, LISX, SCLH, XLIS
  • Links
    NCBI Gene ID: 1641
    neXtProt AC: NX_O43602
    UniProt: O43602

  • Chr Location
    Xq23; chrX:111293779-111412232 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dcx mouse models; 1 with human DCX associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    42 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13193 NCBI Gene Model | MGI Sequence Detail 77434 C57BL/6J ±  kb
    transcript NM_001110222 RefSeq | MGI Sequence Detail 9078 C57BL/6  
    polypeptide O88809 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 219
      cDNA 207
      Primer pair 4
      Other 8

      Microarray probesets 6
    References
    more
    • Summaries
      All 316
      Developmental Gene Expression 247
      Diseases 1
      Gene Ontology 15
      Phenotypes 30
    • Earliest
      J:48963 Sossey-Alaoui K, et al., Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X-linked neuronal migration defects. Hum Mol Genet. 1998 Aug;7(8):1327-32
    • Latest
      J:265671 Gorelik A, et al., Complement C3 Affects Rac1 Activity in the Developing Brain. Front Mol Neurosci. 2018;11:150

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory