Dcx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dcx
doublecortin
MGI:1277171

18 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dcx^tm1.2Ffr/Y either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	abnormal brain interneuron morphology	J:108229
	abnormal rostral migratory stream morphology	J:108229
Dcx^{tm1a(EUCOMM)Wtsi}/Y C57BL/6N-Dcx^{tm1a(EUCOMM)Wtsi}/Wtsi	increased circulating chloride level	J:211773
	increased circulating insulin level	J:211773
	increased circulating sodium level	J:211773
Dcx^tm1Caw/Y involves: 129/Sv * C57BL/6	abnormal hippocampal mossy fiber morphology	J:148345
	abnormal hippocampus CA3 region morphology	J:148345
	abnormal inhibitory postsynaptic currents	J:148345
Dcx^tm1Caw/Dcx⁺ involves: 129S6/SvEvTac * 129X1/SvJ	abnormal avoidance learning behavior	J:78746
	abnormal spatial learning	J:78746
	decreased grip strength	J:78746
Dcx^tm1Caw/Y involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss	abnormal behavior	J:78746
	abnormal hippocampus morphology	J:78746
	abnormal hippocampus pyramidal cell layer	J:78746
	decreased body size	J:78746
	postnatal lethality, incomplete penetrance	J:78746
	premature death	J:78746
	reduced male fertility	J:78746
Dcx^tm1Caw/Dcx⁺ involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss	abnormal avoidance learning behavior	J:78746
	abnormal hippocampus morphology	J:78746
	abnormal hippocampus pyramidal cell layer	J:78746
	decreased grip strength	J:78746

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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