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Sp3
Gene Detail
 Symbol
Name
ID
Sp3
trans-acting transcription factor 3
MGI:1277166
Synonyms D130027J01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
43.35 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:72936427-72980446 bp, - strand
From VEGA annotation of GRCm38

  44020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp3

Human
homologs
Human Homolog SP3, Sp3 transcription factor
NCBI Gene ID 6670
neXtProt AC  NX_Q02447
Human Synonyms  SPR2
Human Chr (Location)  2q31; chr2:173906459-173965702 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(26) Targeted(9)
Genomic Mutations involving Sp3 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a reduced birth body size, skeletal, tooth and hematopoietic defects, and die shortly after birth due to respiratory failure. Homozygous mutant mice bearing a subtle point mutation in the SUMO attachment site show loss of DNA methylation in sumoylation-deficient MEFs.
 
Interactions
Sp3 interacts with 336 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process B cell differentiation, definitive hemopoiesis, ...
Component nucleus, transcriptional repressor complex
Function chromatin binding, core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (65)    Tissues (63)    Images (6)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 18, 19, 21, 23, 24, 27, 28
Assay TypeResults
RNA in situ 53
Western blot 4
RT-PCR 8
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013207 (Evidence)
Ensembl Gene ModelENSMUSG00000027109 (Evidence)
Entrez Gene20687 (Evidence)
Consensus CDS ProjectCCDS16122.1
International Mouse Knockout Project StatusSp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013207 VEGA Gene Model | MGI Sequence Detail 44020 C57BL/6J ±  kb
transcript OTTMUST00000031922 VEGA | MGI Sequence Detail 4181 Not Applicable 
polypeptide OTTMUSP00000014207 VEGA | MGI Sequence Detail 783 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015441 transcription factor Sp3
References (Earliest) J:40975 Sack MN, et al., A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6438-43
(Latest) J:198584 Carver BJ, et al., Interactions between NF-kappaB and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24;288(21):15318-25
All references(71)
Other
accession IDs
MGI:2444244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory