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Sp3 Gene Detail
Summary
  • Symbol
    Sp3
  • Name
    trans-acting transcription factor 3
  • Synonyms
    D130027J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277166
    NCBI Gene: 20687
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:72766774-72810790 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.35 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277166
 protein coding gene Chr2:72766771-72810790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025831
 protein coding gene Chr2:73165483-73217457 (-)
A/J MGP_AJ_G0025809
 protein coding gene Chr2:70299037-70342496 (-)
AKR/J MGP_AKRJ_G0025777
 protein coding gene Chr2:72230246-72278011 (-)
BALB/cJ MGP_BALBcJ_G0025803
 protein coding gene Chr2:70495729-70542173 (-)
C3H/HeJ MGP_C3HHeJ_G0025563
 protein coding gene Chr2:72420983-72468175 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026250
 protein coding gene Chr2:75353959-75406528 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023653
 protein coding gene Chr2:67507796-67554820 (-)
CAST/EiJ MGP_CASTEiJ_G0025027
 protein coding gene Chr2:72667730-72717240 (-)
CBA/J MGP_CBAJ_G0025544
 protein coding gene Chr2:78111618-78164771 (-)
DBA/2J MGP_DBA2J_G0025675
 protein coding gene Chr2:69904385-69949061 (-)
FVB/NJ MGP_FVBNJ_G0025637
 protein coding gene Chr2:69322135-69372505 (-)
LP/J MGP_LPJ_G0025763
 protein coding gene Chr2:73049474-73097102 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025668
 protein coding gene Chr2:80047734-80099277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026307
 protein coding gene Chr2:72308939-72354940 (-)
PWK/PhJ MGP_PWKPhJ_G0024768
 protein coding gene Chr2:69800434-69857293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024576
 protein coding gene Chr2:72542101-72593681 (-)
WSB/EiJ MGP_WSBEiJ_G0025095
 protein coding gene Chr2:72765958-72811135 (-)



Homology
more
  • Human Ortholog
    SP3, Sp3 transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP3, Sp3 transcription factor
  • Synonyms
    SPR2
  • Links
    NCBI Gene ID: 6670
    neXtProt AC: NX_Q02447
    UniProt: Q02447

  • Chr Location
    2q31.1; chr2:173880850-173965702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 1 genetic background
    25 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced birth body size, skeletal, tooth and hematopoietic defects, and die shortly after birth due to respiratory failure. Homozygous mutant mice bearing a subtle point mutation in the SUMO attachment site show loss of DNAmethylation in sumoylation-deficient MEFs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    79
  • cDNA Data
    22
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20687 NCBI Gene Model | MGI Sequence Detail 44017 C57BL/6J ±  kb
    transcript NM_001018042 RefSeq | MGI Sequence Detail 4191 C57BL/6  
    polypeptide O70494 UniProt | EBI | MGI Sequence Detail 783 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444244
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 16
      Gene Ontology 19
      Phenotypes 36
    • Earliest
      J:40975 Sack MN, et al., A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6438-43
    • Latest
      J:342401 Zhao H, et al., The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory