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Sp3 Gene Detail
Summary
  • Symbol
    Sp3
  • Name
    trans-acting transcription factor 3
  • Synonyms
    D130027J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277166
    NCBI Gene: 20687
  • Gene Overview
    MyGene.info: SP3
Location & Maps
more
  • Sequence Map
    Chr2:72936427-72980446 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44020 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.35 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SP3, Sp3 transcription factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SP3, Sp3 transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPR2
  • Links
    NCBI Gene ID: 6670
    neXtProt AC: NX_Q02447

  • Chr Location
    2q31; chr2:173906459-173965702 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 2 alleles in 1 genetic background
    25 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Targeted
    11
  • Genomic Mutations
    7 involving Sp3
  • Incidental Mutations
Homozygous null mice exhibit a reduced birth body size, skeletal, tooth and hematopoietic defects, and die shortly after birth due to respiratory failure. Homozygous mutant mice bearing a subtle point mutation in the SUMO attachment site show loss of DNAmethylation in sumoylation-deficient MEFs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013207 VEGA Gene Model | MGI Sequence Detail 44020 C57BL/6J ±  kb
transcript OTTMUST00000031922 VEGA | MGI Sequence Detail 4181 Not Applicable  
polypeptide OTTMUSP00000014207 VEGA | MGI Sequence Detail 783 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015441 transcription factor Sp3
  • InterPro Domains
    IPR030450 Transcription factor Sp1 family
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2444244
References
more
  • Summaries
    All 72
    Developmental Gene Expression 13
    Gene Ontology 15
    Phenotypes 29
  • Earliest
    J:40975 Sack MN, et al., A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6438-43
  • Latest
    J:221503 Meinders M, et al., Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood. 2015 Mar 19;125(12):1957-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory