Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryo development; embryonic camera-type eye morphogenesis; and hemopoiesis. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; jaw; and lung. Orthologous to human SP3 (Sp3 transcription factor).