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Cdk6
Gene Detail
Symbol

Name
ID
Cdk6
cyclin-dependent kinase 6
MGI:1277162
Synonyms
Crk2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.04 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:3343893-3523218 bp, + strand
From Ensembl annotation of GRCm38

  179326 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk6

Human
homologs
Human Homolog CDK6, cyclin-dependent kinase 6
NCBI Gene ID 1021
neXtProt AC  NX_Q00534
Human Synonyms  MCPH12, PLSTIRE
Human Chr (Location)  7q21-q22; chr7:92604921-92836627 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDK6
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(12) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.
 
Human Diseases Modeled Using Mouse Cdk6 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cdk6 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cell cycle, cell dedifferentiation, ...
Component cell projection, cyclin-dependent protein kinase holoenzyme complex, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (96)    Tissues (35)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
Western blot 22
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000040274 (Evidence)
Entrez Gene12571 (Evidence)
DFCITC1585171, TC1639826, TC1656235, TC1667239
DoTSDT.40170049, DT.97360441, DT.487808
NIA Mouse Gene IndexU306213, U197982
EC2.7.11.22
Consensus CDS ProjectCCDS19062.1
International Mouse Knockout Project StatusCdk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040274 Ensembl Gene Model | MGI Sequence Detail 179326 C57BL/6J ±  kb
transcript ENSMUST00000042410 Ensembl | MGI Sequence Detail 2470 Not Applicable 
polypeptide ENSMUSP00000037925 Ensembl | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(630 from dbSNP Build 137)    SNPs within 2kb including multiple locations(632)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005264 cyclin-dependent kinase 6
References
(Earliest) J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
(Latest) J:213268 Kumar P P, et al., Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. 2014 May 29;:e02805
All references(74)
Other
accession IDs
MGD-MRK-2146, MGI:2140921, MGI:88503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory