Cdk6
Gene Detail

Symbol Name ID

Cdk6 cyclin-dependent kinase 6 MGI:1277162

Synonyms

Crk2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

2.04 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:3344312-3522225 bp, + strand From NCBI annotation of GRCm38   177914 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk6

Human homologs

Human Homolog		CDK6, cyclin-dependent kinase 6
NCBI Gene ID		1021
neXtProt AC		NX_Q00534
Human Synonyms		PLSTIRE
Human Chr (Location)		7q21-q22; chr7:92234235-92465941 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(10) Gene trapped(11)
 

Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	cell cycle, cell dedifferentiation, ...
Component	cell projection, cyclin-dependent protein kinase holoenzyme complex, ...
Function	ATP binding, cyclin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (96)    Tissues (34)    Images (24)
Theiler Stages: 19, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	74
Western blot	22

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000040274 (Evidence)
Entrez Gene	12571 (Evidence)
DFCI	TC1585171, TC1639826, TC1667239
DoTS	DT.40170049, DT.487808, DT.97360441
NIA Mouse Gene Index	U197982, U306213
EC	2.7.11.22
Consensus CDS Project	CCDS19062.1
International Mouse Knockout Project Status	Cdk6

Sequences

Length	Strain/Species
genomic	12571	NCBI Gene Model | MGI Sequence Detail	177914	C57BL/6J
transcript	NM_009873	RefSeq | MGI Sequence Detail	2470	C57BL/6
polypeptide	Q64261	UniProt | EBI | MGI Sequence Detail	326	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(471 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005264	cell division protein kinase 6

Graphical View of Protein Domain Structure

References

(Earliest) J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
(Latest) J:190441 Kreslavsky T, et al., beta-Selection-induced proliferation is required for alphabeta T cell differentiation. Immunity. 2012 Nov 16;37(5):840-53
All references(64)

Other accession IDs

MGD-MRK-2146, MGI:2140921, MGI:88503