About   Help   FAQ
Cdk6
Gene Detail
Symbol

Name
ID
Cdk6
cyclin-dependent kinase 6
MGI:1277162
Synonyms
Crk2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.04 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:3341485-3531008 bp, + strand
From VEGA annotation of GRCm38

  189524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK6
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk6

Human
homologs
CDK6, cyclin-dependent kinase 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1021
neXtProt AC: NX_Q00534

Human Synonyms: MCPH12, PLSTIRE

Human Chr (Location): 7q21-q22; chr7:92604921-92836627 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDK6

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(12) Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Cdk6 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process cell cycle, cell dedifferentiation, ...
Component cell projection, centrosome, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (100)    Tissues (37)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 74
Western blot 22
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk6    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000052940 (Evidence)
Ensembl Gene Model ENSMUSG00000040274 (Evidence)
Entrez Gene 12571 (Evidence)
DFCI TC1585171, TC1639826, TC1656235, TC1667239
DoTS DT.40170049, DT.487808, DT.97360441
NIA Mouse Gene Index U197982, U306213
EC 2.7.11.22
Consensus CDS Project CCDS19062.1
International Mouse Phenotyping Consortium Status Cdk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052940 VEGA Gene Model | MGI Sequence Detail 189524 C57BL/6J ±  kb
transcript OTTMUST00000132480 VEGA | MGI Sequence Detail 11525 Not Applicable 
polypeptide OTTMUSP00000070630 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(666 from dbSNP Build 137)    SNPs within 2kb including multiple locations(668)
Protein-related
information
ResourceIDDescription
InterPro IPR028788 Cyclin-dependent kinase 6
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005264 cyclin-dependent kinase 6
References
(Earliest) J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
(Latest) J:220783 Scheicher R, et al., CDK6 as a key regulator of hematopoietic and leukemic stem cell activation. Blood. 2015 Jan 1;125(1):90-101
All references(77)
Other
accession IDs
MGD-MRK-2146, MGI:2140921, MGI:88503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory