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Cdk6
Gene Detail
 Symbol
Name
ID
Cdk6
cyclin-dependent kinase 6
MGI:1277162
Synonyms Crk2
Feature Type protein coding gene
Genetic Map
Chromosome 5
2.04 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:3344312-3522225 bp, + strand
From NCBI annotation of GRCm38

  177914 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk6

Human
homologs
Human Homolog CDK6, cyclin-dependent kinase 6
NCBI Gene ID 1021
neXtProt AC  NX_Q00534
Human Synonyms  PLSTIRE
Human Chr (Location)  7q21-q22; chr7:92604921-92836627 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(11) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.
 
Human Diseases Modeled Using Mouse Cdk6 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cdk6 interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cell cycle, cell dedifferentiation, ...
Component cell projection, cyclin-dependent protein kinase holoenzyme complex, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (96)    Tissues (34)    Images (24)
Theiler Stages: 19, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 74
Western blot 22
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000040274 (Evidence)
Entrez Gene12571 (Evidence)
DFCITC1585171, TC1639826, TC1656235, TC1667239
DoTSDT.40170049, DT.487808, DT.97360441
NIA Mouse Gene IndexU197982, U306213
EC2.7.11.22
Consensus CDS ProjectCCDS19062.1
International Mouse Knockout Project StatusCdk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12571 NCBI Gene Model | MGI Sequence Detail 177914 C57BL/6J ±  kb
transcript NM_009873 RefSeq | MGI Sequence Detail 2470 C57BL/6 
polypeptide Q64261 UniProt | EBI | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(627 from dbSNP Build 137)    SNPs within 2kb including multiple locations(629)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005264 cyclin-dependent kinase 6
Graphical View of Protein Domain Structure
References (Earliest) J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
(Latest) J:203127 Hussain MS, et al., CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. Hum Mol Genet. 2013 Dec 20;22(25):5199-214
All references(72)
Other
accession IDs
MGD-MRK-2146, MGI:2140921, MGI:88503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory