Gene Expression Literature Summary

• Symbol: Cdk6
• Name: cyclin dependent kinase 6
• ID: MGI:1277162

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)		1	1				1				1	1	1			1		1
In situ RNA (section)							1		1		1	1	1					2
In situ RNA (whole mount)					1	1	2	1
In situ reporter (knock in)																		1
Western blot					1				2	2	3		1	2	1			4
RT-PCR	1		4	1	3		4	1	3			2	3		1	3	1	8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdk6  cyclin dependent kinase 6   (Synonyms: Crk2)
Results	Reference
1*	J:45218 Ahuja HS, Zhu Y, Zakeri Z, Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
3*	J:108720 Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P, Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell. 2006 May;10(5):563-73
2	J:336417 Chong D, Gu Y, Zhang T, Xu Y, Bu D, Chen Z, Xu N, Li L, Zhu X, Wang H, Li Y, Zheng F, Wang D, Li P, Xu L, Hu Z, Li C, Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
1	J:338956 de Campos VS, Magalhaes CF, da Rosa BG, Dos Santos CM, Fragel-Madeira L, Figueiredo DP, Calaza KC, Adesse D, Maternal Toxoplasma gondii infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo. Front Cell Neurosci. 2023;17:1211446
1	J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104
1	J:149918 Fuchs S, Herzog D, Sumara G, Buchmann-Moller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L, Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009 Mar 6;4(3):236-47
3	J:266542 Hasenpusch-Theil K, West S, Kelman A, Kozic Z, Horrocks S, McMahon AP, Price DJ, Mason JO, Theil T, Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression. Development. 2018 Aug 20;145(17):dev163147
2*	J:203127 Hussain MS, Baig SM, Neumann S, Peche VS, Szczepanski S, Nurnberg G, Tariq M, Jameel M, Khan TN, Fatima A, Malik NA, Ahmad I, Altmuller J, Frommolt P, Thiele H, Hohne W, Yigit G, Wollnik B, Neubauer BA, Nurnberg P, Noegel AA, CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly. Hum Mol Genet. 2013 Dec 20;22(25):5199-214
1*	J:181189 Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T, Suzuki T, Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012 Feb;139(4):749-59
3*	J:199186 Juuri E, Saito K, Lefebvre S, Michon F, Establishment of crown-root domain borders in mouse incisor. Gene Expr Patterns. 2013 Oct;13(7):255-64
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1*	J:92563 Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P, Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004 Aug 20;118(4):477-91
1	J:213268 Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM, Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. 2014 May 29;:e02805
3*	J:124353 Landis MW, Brown NE, Baker GL, Shifrin A, Das M, Geng Y, Sicinski P, Hinds PW, The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development. Cancer Res. 2007 Aug 15;67(16):7613-20
3*	J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
2*	J:305376 Li B, Wang Z, Yang F, Huang J, Hu X, Deng S, Tian M, Si X, miR449a5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation. Mol Med Rep. 2021 Jan;23(1)
2	J:184012 Lopez-Rios J, Speziale D, Robay D, Scotti M, Osterwalder M, Nusspaumer G, Galli A, Hollander GA, Kmita M, Zeller R, GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell. 2012 Apr 17;22(4):837-48
1	J:326547 Lu P, Wang P, Wu B, Wang Y, Liu Y, Cheng W, Feng X, Yuan X, Atteya MM, Ferro H, Sugi Y, Rydquist G, Esmaily M, Butcher JT, Chang CP, Lenz J, Zheng D, Zhou B, A SOX17-PDGFB signaling axis regulates aortic root development. Nat Commun. 2022 Jul 13;13(1):4065
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:231817 Matsumoto S, Kiryu-Seo S, Kiyama H, Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57
1*	J:102872 McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A, Soares MB, Bonaldo Mde F, Grimmond S, Hui CC, Wainwright B, Wicking C, Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev. 2005 Nov;122(11):1218-33
3	J:197897 Mi D, Carr CB, Georgala PA, Huang YT, Manuel MN, Jeanes E, Niisato E, Sansom SN, Livesey FJ, Theil T, Hasenpusch-Theil K, Simpson TI, Mason JO, Price DJ, Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron. 2013 Apr 24;78(2):269-84
1	J:344186 Munoz-Gallardo MDM, Garcia-Padilla C, Vicente-Garcia C, Carvajal J, Arenega A, Franco D, miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810
1	J:237505 Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA, PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 Dec 15;143(24):4608-4619
1	J:256929 Otto T, Candido SV, Pilarz MS, Sicinska E, Bronson RT, Bowden M, Lachowicz IA, Mulry K, Fassl A, Han RC, Jecrois ES, Sicinski P, Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10660-10665
1	J:239946 Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV, Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing beta-cells to a delta-like fate and reveals a facultative proliferative capacity in aged beta-cells. Development. 2015 Nov 01;142(21):3637-48
1	J:301859 Poche RA, Zhang M, Rueda EM, Tong X, McElwee ML, Wong L, Hsu CW, Dejosez M, Burns AR, Fox DA, Martin JF, Zwaka TP, Dickinson ME, RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Cell Rep. 2016 Feb 23;14(7):1684-1697
2	J:314288 Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V, Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. Front Physiol. 2019;10:235
1	J:317430 Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021 Dec;17(12):e1009982
3	J:48539 Sunters A, McCluskey J, Grigoriadis AE, Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation. Dev Genet. 1998;22(4):386-97
1	J:246477 Talchai SC, Accili D, Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult beta-Cell Mass and Function. Diabetes. 2015 Aug;64(8):2868-79
1	J:267650 Toyoda M, Shirato H, Nakajima K, Kojima M, Takahashi M, Kubota M, Suzuki-Migishima R, Motegi Y, Yokoyama M, Takeuchi T, jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Dev Cell. 2003 Jul;5(1):85-97
1	J:317370 Trofka A, Huang BL, Zhu J, Heinz WF, Magidson V, Shibata Y, Shi YB, Tarchini B, Stadler HS, Kabangu M, Al Haj Baddar NW, Voss SR, Mackem S, Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates. Curr Biol. 2021 Nov 22;31(22):4923-4934.e5
2	J:214986 Walker EM, Thompson CA, Battle MA, GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Dev Biol. 2014 Aug 15;392(2):283-94
1	J:233746 Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE, Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Dev Biol. 2016 Jun 15;414(2):161-9
1	J:185130 Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G, miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21
1	J:212272 Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W, Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
1	J:187715 Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP, Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14;23(2):280-91
2	J:339247 Zhang C, Li Y, Cao J, Yu B, Zhang K, Li K, Xu X, Guo Z, Liang Y, Yang X, Yang Z, Sun Y, Kaartinen V, Ding K, Wang J, Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation. Open Biol. 2021 Jun;11(6):210020
1*	J:229467 Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suner D, Garcia-Pavia P, Zhang X, Wang Q, Xie L, Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51
1	J:310132 Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L, Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol. 2015 Aug;85:1-12
1	J:241021 Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L, Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1422-E1431
1	J:195854 Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED, Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221
3	J:44526 Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF, Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 1997 Nov;8(11):1139-50