Ptp4a2 MGI Mouse Gene Detail - MGI:1277117 - protein tyrosine phosphatase 4a2

Symbol

Ptp4a2
Name

protein tyrosine phosphatase 4a2
Synonyms

Prl-2

Feature Type

protein coding gene
IDs

MGI:1277117
NCBI Gene: 19244
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:129705012-129743796 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.38 cM, cytoband D2.3
Mapping Data

2 experiments

SNPs within 2kb

451 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277117	protein coding gene	Chr4:129704982-129743800 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028839	protein coding gene	Chr4:131775336-131823960 (+)
A/J	MGP_AJ_G0028798	protein coding gene	Chr4:126498176-126536149 (+)
AKR/J	MGP_AKRJ_G0028751	protein coding gene	Chr4:130022605-130062227 (+)
BALB/cJ	MGP_BALBcJ_G0028821	protein coding gene	Chr4:127096485-127134171 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0029263	protein coding gene	Chr4:136722973-136763374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026535	protein coding gene	Chr4:119622186-119658484 (+)
CAST/EiJ	MGP_CASTEiJ_G0027967	protein coding gene	Chr4:128269462-128312457 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0028617	protein coding gene	Chr4:125685124-125737342 (+)
LP/J	MGP_LPJ_G0028751	protein coding gene	Chr4:132075227-132117853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028643	protein coding gene	Chr4:144913106-144954000 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029301	protein coding gene	Chr4:130392312-130442049 (+)
PWK/PhJ	MGP_PWKPhJ_G0027689	protein coding gene	Chr4:123535243-123574562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027515	protein coding gene	Chr4:126278966-126319976 (+)
WSB/EiJ	MGP_WSBEiJ_G0028048	protein coding gene	Chr4:130527604-130569635 (+)

Human Ortholog

PTP4A2, protein tyrosine phosphatase 4A2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTP4A2, protein tyrosine phosphatase 4A2
Synonyms

HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Links

HGNC:9635

NCBI Gene ID: 8073

UniProt: Q12974
Chr Location

1p35.2; chr1:31906421-31944856 (-) GRCh38

MGI Vertebrate Homology

Ptp4a2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTP4A2
Gene Tree

Ptp4a2

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Phenotype Summary

48 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotypes from multigenic genotypes
3 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

89
Radiation induced

1
Targeted

3
Transgenic

2
Genomic Mutations

4 involving Ptp4a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth. Male mice show atrophied testis and low sperm count, leading to impaired reproductive ability.

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All GO Annotations

20
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

21
cDNA Data

18
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptp4a2

ZFIN ptp4a2a, ptp4a2b

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All Sequences

66
RefSeq

19
UniProt

2
CCDS

CCDS18704.1

Ensembl

ENSMUSG00000028788 (Evidence)
NCBI Gene

19244

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028788	Ensembl Gene Model \| MGI Sequence Detail	38785	C57BL/6J	± kb
transcript	ENSMUST00000030578	Ensembl \| MGI Sequence Detail	3646	Not Applicable
polypeptide	ENSMUSP00000030578	Ensembl \| MGI Sequence Detail	167	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013441 protein tyrosine phosphatase type IVA 2

(term hierarchy)
PDB

5K24
EC

3.1.3.48
InterPro Domains

IPR020422 Dual specificity protein phosphatase domain

IPR050561 Protein Tyrosine Phosphatase

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 6

Summaries

All 63

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 28
Earliest

J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
Latest

J:366630 Nguele Meke F, et al., Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models. Cancer Res Commun. 2024 Jan 2;4(1):5-17

TSS for Ptp4a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39183	Chr4:129704976-129705000 (+)	-24 bp
Tssr39184	Chr4:129705006-129705052 (+)	17 bp
Tssr39185	Chr4:129705436-129705477 (+)	445 bp
Tssr39186	Chr4:129708416-129708422 (+)	3,407 bp
Tssr39197	Chr4:129721090-129721094 (+)	16,080 bp
Tssr39198	Chr4:129732955-129732959 (+)	27,945 bp
Tssr39199	Chr4:129733032-129733062 (+)	28,035 bp
Tssr39200	Chr4:129741639-129741663 (+)	36,639 bp
Tssr39201	Chr4:129742245-129742269 (+)	37,245 bp
Tssr39202	Chr4:129742298-129742308 (+)	37,291 bp
Tssr39203	Chr4:129742486-129742498 (+)	37,480 bp
Tssr39204	Chr4:129742959-129742980 (+)	37,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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