Ptp4a2 MGI Mouse Gene Detail - MGI:1277117 - protein tyrosine phosphatase 4a2

Symbol

Ptp4a2
Name

protein tyrosine phosphatase 4a2
Synonyms

Prl-2

Feature Type

protein coding gene
IDs

MGI:1277117
NCBI Gene: 19244
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:129714262-129743796 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.38 cM, cytoband D2.3
Mapping Data

2 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277117	protein coding gene	Chr4:129705012-129743796 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028839	protein coding gene	Chr4:131775336-131823960 (+)
A/J	MGP_AJ_G0028798	protein coding gene	Chr4:126498176-126536149 (+)
AKR/J	MGP_AKRJ_G0028751	protein coding gene	Chr4:130022605-130062227 (+)
BALB/cJ	MGP_BALBcJ_G0028821	protein coding gene	Chr4:127096485-127134171 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0029263	protein coding gene	Chr4:136722973-136763374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026535	protein coding gene	Chr4:119622186-119658484 (+)
CAST/EiJ	MGP_CASTEiJ_G0027967	protein coding gene	Chr4:128269462-128312457 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0028617	protein coding gene	Chr4:125685124-125737342 (+)
LP/J	MGP_LPJ_G0028751	protein coding gene	Chr4:132075227-132117853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028643	protein coding gene	Chr4:144913106-144954000 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029301	protein coding gene	Chr4:130392312-130442049 (+)
PWK/PhJ	MGP_PWKPhJ_G0027689	protein coding gene	Chr4:123535243-123574562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027515	protein coding gene	Chr4:126278966-126319976 (+)
WSB/EiJ	MGP_WSBEiJ_G0028048	protein coding gene	Chr4:130527604-130569635 (+)

Human Ortholog

PTP4A2, protein tyrosine phosphatase 4A2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTP4A2, protein tyrosine phosphatase 4A2
Synonyms

HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Links

HGNC:9635

NCBI Gene ID: 8073

neXtProt AC: NX_Q12974

UniProt: Q12974
Chr Location

1p35.2; chr1:31906421-31942635 (-) GRCh38.p7

Alliance of Genome Resources

Ptp4a2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTP4A2
Gene Tree

Ptp4a2

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Phenotype Summary

48 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotypes from multigenic genotypes
3 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

77
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

68
Radiation induced

1
Targeted

1
Transgenic

2
Genomic Mutations

4 involving Ptp4a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth. Male mice show atrophied testis and low sperm count, leading to impaired reproductive ability.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

20
cDNA Data

18
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptp4a2

ZFIN ptp4a2a, ptp4a2b

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Ptp4a2 interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

57
RefSeq

10
UniProt

2
CCDS

CCDS18704.1

Ensembl

ENSMUSG00000028788 (Evidence)
NCBI Gene

19244

			Length	Strain/Species	Flank
genomic	19244	NCBI Gene Model \| MGI Sequence Detail	29535	C57BL/6J	± kb
transcript	NM_008974	RefSeq \| MGI Sequence Detail	3413	C57BL/6
polypeptide	O70274	UniProt \| EBI \| MGI Sequence Detail	167	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013441 protein tyrosine phosphatase type IVA 2

(term hierarchy)
PDB

5K24
EC

3.1.3.48
InterPro Domains

IPR020422 Dual specificity protein phosphatase domain

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 20

cDNA 20

Microarray probesets 6

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 23
Earliest

J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
Latest

J:299029 Poulet M, et al., PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling. Commun Biol. 2020 Oct 23;3(1):603

TSS for Ptp4a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39187	Chr4:129713991-129714062 (+)	-235 bp
Tssr39188	Chr4:129714078-129714085 (+)	-180 bp
Tssr39189	Chr4:129714097-129714104 (+)	-161 bp
Tssr39197	Chr4:129721090-129721094 (+)	6,830 bp
Tssr39198	Chr4:129732955-129732959 (+)	18,695 bp
Tssr39199	Chr4:129733032-129733062 (+)	18,785 bp
Tssr39200	Chr4:129741639-129741663 (+)	27,389 bp
Tssr39201	Chr4:129742245-129742269 (+)	27,995 bp
Tssr39202	Chr4:129742298-129742308 (+)	28,041 bp
Tssr39203	Chr4:129742486-129742498 (+)	28,230 bp
Tssr39204	Chr4:129742959-129742980 (+)	28,708 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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