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Ptp4a2 Gene Detail
Summary
  • Symbol
    Ptp4a2
  • Name
    protein tyrosine phosphatase 4a2
  • Synonyms
    Prl-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277117
    NCBI Gene: 19244
  • Gene Overview
    MyGene.info: PTP4A2
Location & Maps
more
  • Sequence Map
    Chr4:129811219-129849978 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38760 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.38 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase type IVA, member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase type IVA, member 2
    Orthology source: HomoloGene
  • Synonyms
    HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
  • Links
    NCBI Gene ID: 8073
    neXtProt AC: NX_Q12974

  • Chr Location
    1p35; chr1:31906421-31938387 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    122
  • Chemically induced (other)
    2
  • Gene trapped
    118
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Ptp4a2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009511 VEGA Gene Model | MGI Sequence Detail 38760 C57BL/6J ±  kb
transcript OTTMUST00000021734 VEGA | MGI Sequence Detail 3646 Not Applicable  
polypeptide OTTMUSP00000009914 VEGA | MGI Sequence Detail 167 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    228 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013441 protein tyrosine phosphatase type IVA 2
  • EC
  • InterPro Domains
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 PTP type protein phosphatase
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
  • Latest
    J:218619 Hardy S, et al., The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. Oncogene. 2015 Feb 19;34(8):986-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory