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Ptp4a2 Gene Detail
Summary
  • Symbol
    Ptp4a2
  • Name
    protein tyrosine phosphatase 4a2
  • Synonyms
    Prl-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277117
    NCBI Gene: 19244
  • Gene Overview
    MyGene.info: PTP4A2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129820204-129850003 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.38 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277117
protein coding gene Chr4:129811219-129850003 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028839
protein coding gene Chr4:131775336-131823960 (+)
A/J MGP_AJ_G0028798
protein coding gene Chr4:126498176-126536149 (+)
AKR/J MGP_AKRJ_G0028751
protein coding gene Chr4:130022605-130062227 (+)
BALB/cJ MGP_BALBcJ_G0028821
protein coding gene Chr4:127096485-127134171 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029263
protein coding gene Chr4:136722973-136763374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026535
protein coding gene Chr4:119622186-119658484 (+)
CAST/EiJ MGP_CASTEiJ_G0027967
protein coding gene Chr4:128269462-128312457 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028617
protein coding gene Chr4:125685124-125737342 (+)
LP/J MGP_LPJ_G0028751
protein coding gene Chr4:132075227-132117853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028643
protein coding gene Chr4:144913106-144954000 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029301
protein coding gene Chr4:130392312-130442049 (+)
PWK/PhJ MGP_PWKPhJ_G0027689
protein coding gene Chr4:123535243-123574562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027515
protein coding gene Chr4:126278966-126319976 (+)
WSB/EiJ MGP_WSBEiJ_G0028048
protein coding gene Chr4:130527604-130569635 (+)



Homology
more
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase type IVA, member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTP4A2, protein tyrosine phosphatase type IVA, member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
  • Links
    NCBI Gene ID: 8073
    neXtProt AC: NX_Q12974
    UniProt: Q12974

  • Chr Location
    1p35.2; chr1:31906421-31942635 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19244 NCBI Gene Model | MGI Sequence Detail 29800 C57BL/6J ±  kb
    transcript NM_008974 RefSeq | MGI Sequence Detail 3413 C57BL/6  
    polypeptide O70274 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 6
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
    • Latest
      J:254330 Sacchetti C, et al., PTP4A1 promotes TGFbeta signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 Oct 20;8(1):1060

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory