Ptp4a2
Gene Detail

Symbol

Name
ID

Ptp4a2
protein tyrosine phosphatase 4a2
MGI:1277117

Synonyms

Prl-2

Feature Type

protein coding gene

Genetic Map

Chromosome 4
63.38 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:129811219-129849978 bp, + strand From VEGA annotation of GRCm38   38760 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prenylated protein tyrosine phosphatase
Gene Tree: Ptp4a2

Human
homologs

Human Homolog		PTP4A2, protein tyrosine phosphatase type IVA, member 2
NCBI Gene ID		8073
neXtProt AC		NX_Q12974
Human Synonyms		HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Human Chr (Location)		1p35; chr1:31906421-31938387 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(119) : Gene trapped(118) Targeted(1)
Genomic Mutations involving Ptp4a2 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth.

 
Phenotype Images(3)

Interactions

Ptp4a2 interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	dephosphorylation, protein dephosphorylation
Component	cytoplasm, endosome, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (26)    Tissues (20)    Images (5)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	26

cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(18)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000009511 (Evidence)
Ensembl Gene Model	ENSMUSG00000028788 (Evidence)
Entrez Gene	19244 (Evidence)
DFCI	TC1595305, TC1583357, TC1573282, TC1700670, TC1625819
DoTS	DT.101394142, DT.101316766, DT.94369370, DT.99839240, DT.91351791, DT.87073123
NIA Mouse Gene Index	U080193, U152425
EC	3.1.3.48
Consensus CDS Project	CCDS18704.1
International Mouse Knockout Project Status	Ptp4a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009511	VEGA Gene Model | MGI Sequence Detail	38760	C57BL/6J
transcript	OTTMUST00000021734	VEGA | MGI Sequence Detail	3646	Not Applicable
polypeptide	OTTMUSP00000009914	VEGA | MGI Sequence Detail	167	Not Applicable

All sequences(61) RefSeq(8) UniProt(2)

Polymorphisms

SNPs within 2kb(236 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013441	protein tyrosine phosphatase type IVA 2

References

(Earliest) J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
(Latest) J:216785 Kobayashi M, et al., PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells. 2014 Jul;32(7):1956-67
All references(36)