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Ptp4a2
Gene Detail
Symbol

Name
ID
Ptp4a2
protein tyrosine phosphatase 4a2
MGI:1277117
Synonyms
Prl-2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
63.38 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:129811219-129849978 bp, + strand
From VEGA annotation of GRCm38

  38760 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20744  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTP4A2
Protein SuperFamily: prenylated protein tyrosine phosphatase
Gene Tree: Ptp4a2

Human
homologs
PTP4A2, protein tyrosine phosphatase type IVA, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8073
neXtProt AC: NX_Q12974

Human Synonyms: HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b

Human Chr (Location): 1p35; chr1:31906421-31938387 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(118) Targeted(1)
Genomic Mutations involving Ptp4a2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth.
 
Phenotype Images(3)
Interactions
Ptp4a2 interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dephosphorylation, protein dephosphorylation
Component cytoplasm, endosome, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (26)    Tissues (20)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptp4a2 ; ZFIN ptp4a2a, ptp4a2b    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000009511 (Evidence)
Ensembl Gene Model ENSMUSG00000028788 (Evidence)
Entrez Gene 19244 (Evidence)
DFCI TC1595305, TC1583357, TC1573282, TC1625819, TC1700670
DoTS DT.101394142, DT.101316766, DT.99839240, DT.94369370, DT.91351791, DT.87073123
NIA Mouse Gene Index U080193, U152425
EC 3.1.3.48
Consensus CDS Project CCDS18704.1
International Mouse Phenotyping Consortium Status Ptp4a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009511 VEGA Gene Model | MGI Sequence Detail 38760 C57BL/6J ±  kb
transcript OTTMUST00000021734 VEGA | MGI Sequence Detail 3646 Not Applicable 
polypeptide OTTMUSP00000009914 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013441 protein tyrosine phosphatase type IVA 2
References
(Earliest) J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
(Latest) J:218619 Hardy S, et al., The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. Oncogene. 2015 Feb 19;34(8):986-95
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory