Ptp4a2 MGI Mouse Gene Detail - MGI:1277117 - protein tyrosine phosphatase 4a2

Ptp4a2 Gene Detail

Symbol

Ptp4a2
Name

protein tyrosine phosphatase 4a2
Synonyms

Prl-2

Feature Type

protein coding gene
IDs

MGI:1277117
NCBI Gene: 19244
Gene Overview

MyGene.info: PTP4A2

Sequence Map

Chr4:129811219-129849978 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

38760 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.38 cM, cytoband D2.3
Mapping Data

2 experiments

Human Ortholog

PTP4A2, protein tyrosine phosphatase type IVA, member 2

Vertebrate Orthologs

9

Human Ortholog

PTP4A2, protein tyrosine phosphatase type IVA, member 2
Orthology source: HomoloGene, HGNC
Synonyms

HH13, HH7-2, HU-PP-1, OV-1, PRL2, PRL-2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Links

HGNC:9635

NCBI Gene ID: 8073

neXtProt AC: NX_Q12974

UniProt: Q12974
Chr Location

1p35.2; chr1:31906421-31942635 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20744
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PTP4A2
Protein SuperFamily

prenylated protein tyrosine phosphatase
Gene Tree

Ptp4a2

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

122
Chemically induced (other)

2
Gene trapped

118
Radiation induced

1
Targeted

1
Genomic Mutations

4 involving Ptp4a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available

Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth.

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All GO Annotations

13
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

20
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptp4a2

ZFIN ptp4a2a, ptp4a2b

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Ptp4a2 interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

48
RefSeq

8
UniProt

2
CCDS

CCDS18704.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000009511	VEGA Gene Model \| MGI Sequence Detail	38760	C57BL/6J	± kb
transcript	OTTMUST00000021734	VEGA \| MGI Sequence Detail	3646	Not Applicable
polypeptide	OTTMUSP00000009914	VEGA \| MGI Sequence Detail	167	Not Applicable

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SNPs within 2kb

228 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000013441 protein tyrosine phosphatase type IVA 2

(term hierarchy)
PDB

5K24
EC

3.1.3.48
InterPro Domains

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 PTP type protein phosphatase

IPR000387 Tyrosine specific protein phosphatases domain

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All nucleic 18

cDNA 18

Microarray probesets 6

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 15
Earliest

J:23094 Davisson MT, New chromosome aberrations. Mouse News Lett. 1988;80:166
Latest

J:239612 Kobayashi M, et al., Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. Leukemia. 2017 Mar;31(3):751-754

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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