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Gfi1b
Gene Detail
Symbol

Name
ID
Gfi1b
growth factor independent 1B
MGI:1276578
Synonyms
Gfi-1B
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:28609455-28621982 bp, - strand
From VEGA annotation of GRCm38

  12528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GFI1B
Gene Tree: Gfi1b

Human
homologs
GFI1B, growth factor independent 1B transcription repressor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8328
neXtProt AC: NX_Q5VTD9

Human Synonyms: BDPLT17, ZNF163B

Human Chr (Location): 9q34.13; chr9:132945545-132993434 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GFI1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos by day E15. Mature adult red blood cells and megakaryocytes fail to develop.
 
Interactions
Gfi1b interacts with 63 markers (Mir19b-1, Mir19b-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process hemopoiesis, multicellular organismal development, ...
Component nuclear matrix, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (32)    Tissues (9)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gfi1b    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011746 (Evidence)
Ensembl Gene Model ENSMUSG00000026815 (Evidence)
Entrez Gene 14582 (Evidence)
UniGene 373385
DFCI TC1586140
DoTS DT.487771
NIA Mouse Gene Index U022451
Consensus CDS Project CCDS15843.1, CCDS50549.1
International Mouse Phenotyping Consortium Status Gfi1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011746 VEGA Gene Model | MGI Sequence Detail 12528 C57BL/6J ±  kb
transcript OTTMUST00000027549 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000012517 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000007942 zinc finger protein Gfi-1b
References
(Earliest) J:47010 Tong B, et al., The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol. 1998 May;18(5):2462-73
(Latest) J:217367 Vassen L, et al., Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression. PLoS One. 2014;9(5):e96636
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory