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Gfi1b
Gene Detail
 Symbol
Name
ID
Gfi1b
growth factor independent 1B
MGI:1276578
Synonyms Gfi-1B
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:28609455-28621982 bp, - strand
From VEGA annotation of GRCm38

  12528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gfi1b

Human
homologs
Human Homolog GFI1B, growth factor independent 1B transcription repressor
NCBI Gene ID 8328
neXtProt AC  NX_Q5VTD9
Human Synonyms  BDPLT17
Human Chr (Location)  9q34.13; chr9:132978411-132991697 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GFI1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene die as embryos by day E15. Mature adult red blood cells and megakaryocytes fail to develop.
 
Interactions
Gfi1b interacts with 63 markers (Mir19b-1, Mir19b-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process multicellular organismal development, negative regulation of histone H3-K4 methylation, ...
Component nuclear matrix, nucleus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (32)    Tissues (9)    Images (24)
Theiler Stages: 2, 3, 4, 5, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011746 (Evidence)
Ensembl Gene ModelENSMUSG00000026815 (Evidence)
Entrez Gene14582 (Evidence)
UniGene373385
DFCITC1586140
DoTSDT.487771
NIA Mouse Gene IndexU022451
Consensus CDS ProjectCCDS15843.1, CCDS50549.1
International Mouse Knockout Project StatusGfi1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011746 VEGA Gene Model | MGI Sequence Detail 12528 C57BL/6J ±  kb
transcript OTTMUST00000027549 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000012517 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000007942 zinc finger protein Gfi-1b
References (Earliest) J:47010 Tong B, et al., The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol. 1998 May;18(5):2462-73
(Latest) J:211681 Yao H, et al., Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 2014 May 15;123(20):3175-84
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory