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Birc6
Gene Detail
Symbol

Name
ID
Birc6
baculoviral IAP repeat-containing 6
MGI:1276108
Synonyms
A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
45.64 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:74528295-74703356 bp, + strand
From VEGA annotation of GRCm38

  175062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Birc6

Human
homologs
Human Homolog   BIRC6, baculoviral IAP repeat containing 6
NCBI Gene ID 57448
neXtProt AC  NX_Q9NR09
Human Synonyms  APOLLON, BRUCE
Human Chr (Location)  2p22.3; chr2:32357028-32618899 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Chemically induced (ENU)(1) Gene trapped(74) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
 
Interactions
Birc6 interacts with 450 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (48)    Tissues (30)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
Northern blot 24
Western blot 6
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042370 VEGA Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
transcript OTTMUST00000114557 VEGA | MGI Sequence Detail 14649 Not Applicable 
polypeptide OTTMUSP00000063931 VEGA | MGI Sequence Detail 4882 Not Applicable 

For the selected sequences
All sequences(162) RefSeq(28) UniProt(11)
Polymorphisms
SNPs within 2kb(625 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR022103 Protein of unknown function DUF3643
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004754 baculoviral IAP repeat-containing protein 6
References
(Earliest) J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
(Latest) J:220313 Ge C, et al., BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1210-9
All references(55)
Other
accession IDs
MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory