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Birc6
Gene Detail
Symbol

Name
ID
Birc6
baculoviral IAP repeat-containing 6
MGI:1276108
Synonyms
A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
45.64 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:74528295-74703356 bp, + strand
From VEGA annotation of GRCm38

  175062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BIRC6
Gene Tree: Birc6

Human
homologs
BIRC6, baculoviral IAP repeat containing 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57448
neXtProt AC: NX_Q9NR09

Human Synonyms: APOLLON, BRUCE

Human Chr (Location): 2p22.3; chr2:32357028-32618899 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Chemically induced (ENU)(1) Gene trapped(74) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
 
Interactions
Birc6 interacts with 450 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (48)    Tissues (30)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
Northern blot 24
Western blot 6
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase birc6    NEW 
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000042370 (Evidence)
Ensembl Gene Model ENSMUSG00000024073 (Evidence)
Entrez Gene 12211 (Evidence)
DFCI TC1577777, TC1623907, TC1619456, TC1717552, TC1632040, TC1668537, TC1634612
DoTS DT.91307295, DT.40139759, DT.87057586, DT.103567868, DT.40169940, DT.102544196, DT.101708241, DT.101127629, DT.91572247, DT.99839898, DT.91336624
NIA Mouse Gene Index U376505, U018226
EC 6.3.2.-
Consensus CDS Project CCDS37693.2
International Mouse Phenotyping Consortium Status Birc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042370 VEGA Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
transcript OTTMUST00000114557 VEGA | MGI Sequence Detail 14649 Not Applicable 
polypeptide OTTMUSP00000063931 VEGA | MGI Sequence Detail 4882 Not Applicable 

For the selected sequences
All sequences(162) RefSeq(28) UniProt(11)
Polymorphisms
SNPs within 2kb(625 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR022103 Protein of unknown function DUF3643
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004754 baculoviral IAP repeat-containing protein 6
References
(Earliest) J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
(Latest) J:220313 Ge C, et al., BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1210-9
All references(53)
Other
accession IDs
MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory