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Birc6
Gene Detail
 Symbol
Name
ID
Birc6
baculoviral IAP repeat-containing 6
MGI:1276108
Synonyms A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
45.64 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:74528295-74703356 bp, + strand
From VEGA annotation of GRCm38

  175062 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Birc6

Human
homologs
Human Homolog BIRC6, baculoviral IAP repeat containing 6
NCBI Gene ID 57448
neXtProt AC  NX_Q9NR09
Human Synonyms  APOLLON, BRUCE
Human Chr (Location)  2p22.3; chr2:32356667-32618899 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Chemically induced (ENU)(1) Gene trapped(74) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
 
Interactions
Birc6 interacts with 451 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (48)    Tissues (30)    Images (10)
Theiler Stages: 10, 17, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 18
Northern blot 24
Western blot 6
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000042370 (Evidence)
Ensembl Gene ModelENSMUSG00000024073 (Evidence)
Entrez Gene12211 (Evidence)
DFCITC1577777, TC1619456, TC1623907, TC1632040, TC1634612, TC1668537, TC1717552
DoTSDT.101127629, DT.101708241, DT.102544196, DT.103567868, DT.40139759, DT.40169940, DT.87057586, DT.91307295, DT.91336624, DT.91572247, DT.99839898
NIA Mouse Gene IndexU018226, U376505
EC6.3.2.-
Consensus CDS ProjectCCDS37693.2
International Mouse Knockout Project StatusBirc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042370 VEGA Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
transcript OTTMUST00000114557 VEGA | MGI Sequence Detail 14649 Not Applicable 
polypeptide OTTMUSP00000063931 VEGA | MGI Sequence Detail 4882 Not Applicable 

For the selected sequences
All sequences(165) RefSeq(28) UniProt(12)
Polymorphisms SNPs within 2kb(625 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR022103 Protein of unknown function DUF3643
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004754 baculoviral IAP repeat-containing protein 6
References (Earliest) J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(53)
Other
accession IDs
MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory