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Birc6 Gene Detail
Summary
  • Symbol
    Birc6
  • Name
    baculoviral IAP repeat-containing 6
  • Synonyms
    A430032G04Rik, A430040A19Rik, apollon, Bruce, D630005A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276108
    NCBI Gene: 12211
  • Gene Overview
    MyGene.info: BIRC6
Location & Maps
more
  • Sequence Map
    Chr17:74528295-74703356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      175062 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 45.64 cM, cytoband E3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BIRC6, baculoviral IAP repeat containing 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APOLLON, BRUCE
  • Links
    NCBI Gene ID: 57448
    neXtProt AC: NX_Q9NR09

  • Chr Location
    2p22.3; chr2:32357028-32618899 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 6 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    77
  • Chemically induced (ENU)
    1
  • Gene trapped
    74
  • Targeted
    2
  • Incidental Mutations
Homozygous mice exhibit perinatal lethality and exhibit placental defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042370 VEGA Gene Model | MGI Sequence Detail 175062 C57BL/6J ±  kb
transcript OTTMUST00000114557 VEGA | MGI Sequence Detail 14649 Not Applicable  
polypeptide OTTMUSP00000063931 VEGA | MGI Sequence Detail 4882 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    623 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000004754 baculoviral IAP repeat-containing protein 6
  • EC
  • InterPro Domains
    IPR022103 Baculoviral IAP repeat-containing protein 6
    IPR001370 BIR repeat
    IPR000608 Ubiquitin-conjugating enzyme E2
    IPR016135 Ubiquitin-conjugating enzyme/RWD-like
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 32
    cDNA 32

    Microarray probesets 5
Other
Accession IDs
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MGI:2442816, MGI:2444799, MGI:2444861, MGI:3034286
References
more
  • Summaries
    All 50
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 13
  • Earliest
    J:48143 Hauser HP, et al., A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol. 1998 Jun 15;141(6):1415-22
  • Latest
    J:220313 Ge C, et al., BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1210-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory