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Cidea
Gene Detail
Symbol

Name
ID
Cidea
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
MGI:1270845
Feature Type
protein coding gene
Genetic Map
Chromosome 18
39.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:67343564-67367794 bp, + strand
From NCBI annotation of GRCm38

  24231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CIDEA
Gene Tree: Cidea

Human
homologs
CIDEA, cell death-inducing DFFA-like effector a
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1149
neXtProt AC: NX_O60543

Human Synonyms: CIDE-A

Human Chr (Location): 18p11.21; chr18:12254319-12277595 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
 
Mice homozygous for disruptions in this gene display higher metabolic rates and an increased ability to maintain core body temperature on cold exposure. They are also resistant to obesity when on a high fat diet.
 
Interactions
Cidea interacts with 25 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process apoptotic process, cell death, ...
Component cytoplasm, intracellular, ...
Function protein binding, protein homodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (11)    Tissues (4)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 11
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cidea    NEW 
Molecular
reagents
All nucleic(61) cDNA(59) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024526 (Evidence)
Entrez Gene 12683 (Evidence)
UniGene 449
DFCI TC1590174, TC1578626
DoTS DT.534563
NIA Mouse Gene Index U018842
Consensus CDS Project CCDS37846.1
International Mouse Phenotyping Consortium Status Cidea
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12683 NCBI Gene Model | MGI Sequence Detail 24231 C57BL/6J ±  kb
transcript NM_007702 RefSeq | MGI Sequence Detail 1164 C57BL/6 
polypeptide O70302 UniProt | EBI | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003508 Caspase-activated nuclease CIDE-N
Protein Ontology PR:000005492 cell death activator CIDE-A
Graphical View of Protein Domain Structure
References
(Earliest) J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
(Latest) J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
All references(42)
Other
accession IDs
MGI:2147356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory