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Cidea Gene Detail
Summary
  • Symbol
    Cidea
  • Name
    cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270845
    NCBI Gene: 12683
Location & Maps
more
  • Sequence Map
    Chr18:67343564-67367794 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24231 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CIDEA, cell death-inducing DFFA-like effector a
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CIDEA, cell death-inducing DFFA-like effector a
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIDE-A
  • Links
    NCBI Gene ID: 1149
    neXtProt AC: NX_O60543

  • Chr Location
    18p11.21; chr18:12254319-12277595 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 77852
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CIDEA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Gene trapped
    17
  • Targeted
    4
  • Transgenic
    4
Nullizygous mice show higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. They are lean and resistant to diet-induced obesity. Aging homozygotes exhibit dry eyes and hair, reduced sebaceous lipid secretion,hair loss, and poor water repulsion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12683 NCBI Gene Model | MGI Sequence Detail 24231 C57BL/6J ±  kb
transcript NM_007702 RefSeq | MGI Sequence Detail 1164 C57BL/6  
polypeptide O70302 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    161 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005492 cell death activator CIDE-A
  • InterPro Domains
    IPR003508 CIDE-N domain
Molecular
Reagents
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  • All nucleic 61
    cDNA 59
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147356
References
more
  • Summaries
    All 39
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
  • Latest
    J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory