Zfp106 MGI Mouse Gene Detail - MGI:1270153

Zfp106 Gene Detail

Symbol

Zfp106
Name

zinc finger protein 106
Synonyms

Cd-1, H3a, Sh3bp3, sirm

Feature Type

protein coding gene
IDs

MGI:1270153
NCBI Gene: 20402
Gene Overview

MyGene.info: ZNF106

Sequence Map

Chr2:120506820-120563843 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

57024 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.37 cM, cytoband F1
Mapping Data

8 experiments

Human Ortholog

ZNF106, zinc finger protein 106

Vertebrate Orthologs

9

Human Ortholog

ZNF106, zinc finger protein 106
Orthology source: HomoloGene, HGNC
Synonyms

SH3BP3, ZFP106, ZNF474
Links

HGNC:12886

NCBI Gene ID: 64397

neXtProt AC: NX_Q9H2Y7
Chr Location

15q15.1; chr15:42412437-42491197 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 40787
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: ZNF106
Gene Tree

Zfp106

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Phenotype Summary

48 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (other)

1
Gene trapped

95
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Zfp106
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a null allele exhibit an abnormal gait, progressive motor deficits, kyphosis, weight loss, severe adult-onset degenerative sensory-motor axonopathy, mitochondrial dysfunction, and premature death.

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All GO Annotations

10
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

46
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase znf106

ZFIN znf106a

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Zfp106 interacts with 386 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

77
RefSeq

6
UniProt

9
CCDS

CCDS16621.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015618	VEGA Gene Model \| MGI Sequence Detail	57024	C57BL/6J	± kb
transcript	OTTMUST00000037093	VEGA \| MGI Sequence Detail	9085	Not Applicable
polypeptide	OTTMUSP00000016632	VEGA \| MGI Sequence Detail	1888	Not Applicable

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SNPs within 2kb

427 from dbSNP Build 142

PCR

2

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UniProt

9 Sequences
InterPro Domains

IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat

IPR001680 WD40 repeat

IPR017986 WD40-repeat-containing domain

IPR015943 WD40/YVTN repeat-like-containing domain

IPR007087 Zinc finger, C2H2

IPR015880 Zinc finger, C2H2-like

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All nucleic 34

Genomic 4

cDNA 25

Primer pair 5

Microarray probesets 9

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MGD-MRK-25981, MGI:104549

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 16
Earliest

J:10078 Roopenian DC, et al., Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics. 1989;30(5):335-43
Latest

J:229162 Joyce PI, et al., Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration. Hum Mol Genet. 2016 Jan 15;25(2):291-307

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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