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Zfp106 Gene Detail
Summary
  • Symbol
    Zfp106
  • Name
    zinc finger protein 106
  • Synonyms
    Cd-1, H3a, Sh3bp3, sirm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270153
    NCBI Gene: 20402
  • Gene Overview
    MyGene.info: ZNF106
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:120506820-120563843 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      57024 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM, cytoband F1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ZNF106, zinc finger protein 106
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNF106, zinc finger protein 106
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SH3BP3, ZFP106, ZNF474
  • Links
    NCBI Gene ID: 64397
    neXtProt AC: NX_Q9H2Y7
    UniProt: Q9H2Y7

  • Chr Location
    15q15.1; chr15:42412437-42491197 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Zfp106 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an abnormal gait, progressive motor deficits, kyphosis, weight loss, severe adult-onset degenerative sensory-motor axonopathy, mitochondrial dysfunction, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    46
  • cDNA Data
    24
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015618 VEGA Gene Model | MGI Sequence Detail 57024 C57BL/6J ±  kb
transcript OTTMUST00000037093 VEGA | MGI Sequence Detail 9085 Not Applicable  
polypeptide OTTMUSP00000016632 VEGA | MGI Sequence Detail 1888 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    427 from dbSNP Build 142
  • PCR
    2
Protein
Information
less
  • UniProt
    9 Sequences
  • InterPro Domains
    IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013087 Zinc finger C2H2-type
Molecular
Reagents
less
  • All nucleic 34
    Genomic 4
    cDNA 25
    Primer pair 5

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-25981, MGI:104549
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 3
    Phenotypes 20
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory