Bap1
Gene Detail

Symbol Name ID

Bap1 Brca1 associated protein 1 MGI:1206586

Synonyms

2300006C11Rik, mKIAA0272

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:31251489-31259929 bp, + strand From NCBI annotation of GRCm38   8441 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3421  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bap1

Human homologs

Human Homolog		BAP1, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
NCBI Gene ID		8314
neXtProt AC		NX_Q92560
Human Synonyms		HUCEP-13, TPDS, UCHL2
Human Chr (Location)		3p21.31-p21.2; chr3:52435024-52444009 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human BAP1

Alleles and phenotypes

All alleles(13) : Targeted(9) Gene trapped(4)
Human Diseases Modeled Using Mouse Bap1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	chromatin modification, monoubiquitinated histone H2A deubiquitination, ...
Component	cytoplasm, intracellular, ...
Function	chromatin binding, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (26)    Tissues (7)   
Theiler Stages: 28

Assay Type	Results
RNA in situ	14
Northern blot	12

cDNA source data(175)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(178) cDNA(175) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021901 (Evidence)
Entrez Gene	104416 (Evidence)
UniGene	3779
DFCI	TC1573310
DoTS	DT.110758382, DT.97336930, DT.97383078
NIA Mouse Gene Index	U015462
EC	3.4.19.12
Consensus CDS Project	CCDS26910.1
International Mouse Knockout Project Status	Bap1

Sequences

Length	Strain/Species
genomic	104416	NCBI Gene Model | MGI Sequence Detail	8441	C57BL/6J
transcript	NM_027088	RefSeq | MGI Sequence Detail	3406	NOD
polypeptide	Q99PU7	UniProt | EBI | MGI Sequence Detail	728	Not Applicable

All sequences(36) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001578	Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
Protein Ontology	PR:000004641	ubiquitin carboxyl-terminal hydrolase BAP1

Graphical View of Protein Domain Structure

References

(Earliest) J:46396 Jensen DE, et al., BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 1998 Mar 5;16(9):1097-112
(Latest) J:187380 Dey A, et al., Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012 Sep 21;337(6101):1541-6
All references(37)

Other accession IDs

MGI:1916715, MGI:2145590, MGI:2145836