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Slc16a2
Gene Detail
Symbol

Name
ID
Slc16a2
solute carrier family 16 (monocarboxylic acid transporters), member 2
MGI:1203732
Synonyms
MCT8, XPCT
Feature Type
protein coding gene
Genetic Map
Chromosome X
46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:103697414-103821965 bp, - strand
From VEGA annotation of GRCm38

  124552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC16A2
Gene Tree: Slc16a2

Human
homologs
SLC16A2, solute carrier family 16, member 2 (thyroid hormone transporter)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6567
neXtProt AC: NX_P36021

Human Synonyms: AHDS, DXS128, DXS128E, MCT7, MCT 7, MCT8, MCT 8, MRX22, XPCT

Human Chr (Location): Xq13.2; chrX:74421493-74533929 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC16A2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homo- and hemizygous inactivation of this gene leads to abnormal thyroid hormone metabolism with no apparent neurological phenotype. Males hemizygous for a knock-out allele also show altered deiodinase enzymatic activities, reduced serum cholesterol and increased serum alkaline phosphatase levels.
 
Human Diseases Modeled in Mice Using Slc16a2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc16a2 interacts with 334 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (287)    Tissues (72)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 200
Northern blot 12
Western blot 21
RT-PCR 32
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SLC16A2 ; Xenbase LOC100494635 ; ZFIN slc16a2    NEW 
Molecular
reagents
All nucleic(28) Genomic(8) cDNA(16) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000018361 (Evidence)
Ensembl Gene Model ENSMUSG00000033965 (Evidence)
Entrez Gene 20502 (Evidence)
DFCI TC1587430, TC1669236, TC1577557
DoTS DT.97405354, DT.91557880, DT.87078192, DT.490815
NIA Mouse Gene Index U039601
Consensus CDS Project CCDS30330.1
International Mouse Phenotyping Consortium Status Slc16a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018361 VEGA Gene Model | MGI Sequence Detail 124552 C57BL/6J ±  kb
transcript OTTMUST00000044352 VEGA | MGI Sequence Detail 4134 Not Applicable 
polypeptide OTTMUSP00000019930 VEGA | MGI Sequence Detail 545 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(249 from dbSNP Build 137)    SNPs within 2kb including multiple locations(273)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000014950 monocarboxylate transporter 8
References
(Earliest) J:46800 Debrand E, et al., Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene. Genomics. 1998 Mar 15;48(3):296-303
(Latest) J:218347 Ferrara AM, et al., Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice. Endocrinology. 2014 Oct;155(10):4088-93
All references(58)
Disease annotation references (1)
Other
accession IDs
MGI:2147994

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory