Slc16a2
Gene Detail

Symbol Name ID

Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 MGI:1203732

Synonyms

MCT8, XPCT

Feature Type

protein coding gene

Genetic Map

Chromosome X

46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:103697414-103821965 bp, - strand From VEGA annotation of GRCm38   124552 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc16a2 ± 2 cM)

Gene Tree: Slc16a2

Human ortholog

SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) NCBI Gene ID 6567
Human Synonyms: AHDS, DXS128, DXS128E, MCT7, MCT 7, MCT8, MCT 8, MRX22, XPCT
Human ChrX:73641085-73753752 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SLC16A2 (1)

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homo- and hemizygous inactivation of this gene leads to abnormal thyroid hormone metabolism with no apparent neurological phenotype. Males hemizygous for a knock-out allele also show altered deiodinase enzymatic activities, reduced serum cholesterol and increased serum alkaline phosphatase levels.

 
Human Diseases Modeled Using Mouse Slc16a2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	hormone transport, thyroid hormone transport, ...
Component	integral to membrane, membrane, ...
Function	symporter activity, thyroid hormone transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (246)    Tissues (53)    Images (21)
Theiler Stages: 10, 18, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	200
Northern blot	12
RT-PCR	12

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) Genomic(8) cDNA(87) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018361 (Evidence)
Ensembl Gene Model	ENSMUSG00000033965 (Evidence)
Entrez Gene	20502 (Evidence)
UniGene	388973
DFCI	TC1577557, TC1587430, TC1669236
DoTS	DT.490815, DT.87078192, DT.91557880, DT.97405354
NIA Mouse Gene Index	U039601
Consensus CDS Project	CCDS30330.1
International Mouse Knockout Project Status	Slc16a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018361	VEGA Gene Model | MGI Sequence Detail	124552	C57BL/6J
transcript	OTTMUST00000044352	VEGA | MGI Sequence Detail	4134	Not Applicable
polypeptide	OTTMUSP00000019930	VEGA | MGI Sequence Detail	545	Not Applicable

All sequences(41) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(222 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000014950	monocarboxylate transporter 8

References

(Earliest) J:46800 Debrand E, et al., Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene. Genomics. 1998 Mar 15;48(3):296-303
(Latest) J:189202 Abe S, et al., Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012 Aug;153(8):4049-58
All references(48)

Other accession IDs

MGI:2147994