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Slc16a2
Gene Detail
Symbol

Name
ID
Slc16a2
solute carrier family 16 (monocarboxylic acid transporters), member 2
MGI:1203732
Synonyms
MCT8, XPCT
Feature Type
protein coding gene
Genetic Map
Chromosome X
46.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:103697414-103821965 bp, - strand
From VEGA annotation of GRCm38

  124552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc16a2

Human
homologs
Human Homolog SLC16A2, solute carrier family 16, member 2 (thyroid hormone transporter)
NCBI Gene ID 6567
neXtProt AC  NX_P36021
Human Synonyms  AHDS, DXS128, DXS128E, MCT7, MCT 7, MCT8, MCT 8, MRX22, XPCT
Human Chr (Location)  Xq13.2; chrX:74421493-74533929 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC16A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homo- and hemizygous inactivation of this gene leads to abnormal thyroid hormone metabolism with no apparent neurological phenotype. Males hemizygous for a knock-out allele also show altered deiodinase enzymatic activities, reduced serum cholesterol and increased serum alkaline phosphatase levels.
 
Human Diseases Modeled Using Mouse Slc16a2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc16a2 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (246)    Tissues (60)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 200
Northern blot 12
RT-PCR 12
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(8) cDNA(16) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018361 (Evidence)
Ensembl Gene ModelENSMUSG00000033965 (Evidence)
Entrez Gene20502 (Evidence)
DFCITC1587430, TC1669236, TC1577557
DoTSDT.490815, DT.97405354, DT.91557880, DT.87078192
NIA Mouse Gene IndexU039601
Consensus CDS ProjectCCDS30330.1
International Mouse Knockout Project StatusSlc16a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018361 VEGA Gene Model | MGI Sequence Detail 124552 C57BL/6J ±  kb
transcript OTTMUST00000044352 VEGA | MGI Sequence Detail 4134 Not Applicable 
polypeptide OTTMUSP00000019930 VEGA | MGI Sequence Detail 545 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(249 from dbSNP Build 137)    SNPs within 2kb including multiple locations(273)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000014950 monocarboxylate transporter 8
References
(Earliest) J:46800 Debrand E, et al., Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene. Genomics. 1998 Mar 15;48(3):296-303
(Latest) J:212769 Mayerl S, et al., Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. J Clin Invest. 2014 May 1;124(5):1987-99
All references(56)
Disease annotation references (1)
Other
accession IDs
MGI:2147994

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory