About   Help   FAQ
Slc16a2 Gene Detail
Summary
  • Symbol
    Slc16a2
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 2
  • Synonyms
    MCT8, XPCT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203732
    NCBI Gene: 20502
  • Gene Overview
    MyGene.info: SLC16A2
Location & Maps
more
  • Sequence Map
    ChrX:103697414-103821983 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      124570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 46.29 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC16A2, solute carrier family 16 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC16A2, solute carrier family 16 member 2
    Orthology source: HomoloGene
  • Synonyms
    AHDS, DXS128, DXS128E, MCT7, MCT 7, MCT8, MCT 8, MRX22, XPCT
  • Links
    NCBI Gene ID: 6567
    neXtProt AC: NX_P36021

  • Chr Location
    Xq13.2; chrX:74421493-74533929 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Slc16a2 mouse models; 1 with human SLC16A2 associations

Human Disease Mouse Models
       Allan-Herndon-Dudley Syndrome; AHDS   OMIM: 300523 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
Homo- and hemizygous inactivation of this gene leads to abnormal thyroid hormone metabolism with no apparent neurological phenotype. Males hemizygous for a knock-out allele also show altered deiodinase enzymatic activities, reduced serum cholesterol and increased serum alkaline phosphatase levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018361 VEGA Gene Model | MGI Sequence Detail 124570 C57BL/6J ±  kb
transcript OTTMUST00000044352 VEGA | MGI Sequence Detail 4152 Not Applicable  
polypeptide OTTMUSP00000019930 VEGA | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    235 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014950 monocarboxylate transporter 8
  • InterPro Domains
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR030761 Monocarboxylate transporter 8
Molecular
Reagents
less
  • All nucleic 28
    Genomic 8
    cDNA 16
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147994
References
more
  • Summaries
    All 58
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:46800 Debrand E, et al., Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene. Genomics. 1998 Mar 15;48(3):296-303
  • Latest
    J:218347 Ferrara AM, et al., Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice. Endocrinology. 2014 Oct;155(10):4088-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory