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Sema6a
Gene Detail
Symbol

Name
ID
Sema6a
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
MGI:1203727
Synonyms
A730020P05Rik, sema, Sema6A-1, Semaq, VIa
Feature Type
protein coding gene
Genetic Map
Chromosome 18
25.08 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:47235598-47368870 bp, - strand
From VEGA annotation of GRCm38

  133273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEMA6A
Protein SuperFamily: semaphorin
Gene Tree: Sema6a

Human
homologs
SEMA6A, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57556
neXtProt AC: NX_Q9H2E6

Human Synonyms: HT018, SEMA, SEMA6A1, SEMAQ, VIA

Human Chr (Location): 5q23.1; chr5:116443555-116574926 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Sema6a interacts with 353 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process apoptotic process, axon guidance, ...
Component axon, integral component of membrane, ...
Function protein binding, semaphorin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (357)    Tissues (97)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 357
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sema6a ; ZFIN sema6a    NEW 
Molecular
reagents
All nucleic(17) cDNA(15) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000033972 (Evidence)
Ensembl Gene Model ENSMUSG00000019647 (Evidence)
Entrez Gene 20358 (Evidence)
DFCI TC1601836, TC1596209, TC1593163, TC1655850, TC1581576, TC1590377
DoTS DT.101734745, DT.101734743, DT.101734744, DT.40150619, DT.55283455, DT.94275211, DT.87043314
NIA Mouse Gene Index U302086, U038415
PDB 3AFC, 3OKY, 3OKW, 3AL8
Consensus CDS Project CCDS37813.1
International Mouse Phenotyping Consortium Status Sema6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033972 VEGA Gene Model | MGI Sequence Detail 133273 C57BL/6J ±  kb
transcript OTTMUST00000085731 VEGA | MGI Sequence Detail 4339 Not Applicable 
polypeptide OTTMUSP00000046342 VEGA | MGI Sequence Detail 1048 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014629 semaphorin-6A
References
(Earliest) J:37600 Puschel AW, et al., The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 1996 May;7(5):419-31
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(75)
Other
accession IDs
MGI:2147277, MGI:2443196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory