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Sema6a Gene Detail
Summary
  • Symbol
    Sema6a
  • Name
    sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
  • Synonyms
    A730020P05Rik, sema, Sema6A-1, Semaq, VIa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203727
    NCBI Gene: 20358
  • Gene Overview
    MyGene.info: SEMA6A
Location & Maps
more
  • Sequence Map
    Chr18:47235598-47368870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      133273 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 25.08 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SEMA6A, semaphorin 6A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEMA6A, semaphorin 6A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HT018, SEMA, SEMA6A1, SEMAQ, VIA
  • Links
    NCBI Gene ID: 57556
    neXtProt AC: NX_Q9H2E6

  • Chr Location
    5q23.1; chr5:116443555-116574926 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033972 VEGA Gene Model | MGI Sequence Detail 133273 C57BL/6J ±  kb
transcript OTTMUST00000085731 VEGA | MGI Sequence Detail 4339 Not Applicable  
polypeptide OTTMUSP00000046342 VEGA | MGI Sequence Detail 1048 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    610 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    cDNA 16
    Other 2

    Microarray probesets 9
Other
Accession IDs
less
MGI:2147277, MGI:2443196
References
more
  • Summaries
    All 77
    Developmental Gene Expression 36
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:37600 Puschel AW, et al., The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 1996 May;7(5):419-31
  • Latest
    J:227692 van Erp S, et al., Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Dev Cell. 2015 Dec 7;35(5):537-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory