Sema6a
Gene Detail

Symbol Name ID

Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A MGI:1203727

Synonyms

A730020P05Rik, b2b997Clo, sema, Sema6A-1, Semaq, VIa

Feature Type

protein coding gene

Genetic Map

Chromosome 18

25.08 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:47235598-47368870 bp, - strand From VEGA annotation of GRCm38   133273 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema6a

Human homologs

Human Homolog		SEMA6A, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NCBI Gene ID		57556
neXtProt AC		NX_Q9H2E6
Human Synonyms		HT018, SEMA, SEMA6A1, SEMAQ, VIA
Human Chr (Location)		5q23.1; chr5:115779251-115910551 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(2) Chemically induced(1)
 

Mice homozygous for a gene trap mutation show a normal phenotype although some axon projections are misdirected. Mice homozygous for an ENU-induced mutation exhibit heterotaxy including pulmonary isomerism, and congenital heart defects.

 
Phenotype Images(10)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	apoptotic process, axon guidance, ...
Component	axon, integral to membrane, ...
Function	protein binding, receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (357)    Tissues (97)    Images (43)
Theiler Stages: 19, 20, 21, 22, 23, 24

Assay Type	Results
RNA in situ	357

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Other(2)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000033972 (Evidence)
Ensembl Gene Model	ENSMUSG00000019647 (Evidence)
Entrez Gene	20358 (Evidence)
DFCI	TC1581576, TC1590377, TC1593163, TC1596209, TC1601836, TC1655850
DoTS	DT.101734743, DT.101734744, DT.101734745, DT.40150619, DT.55283455, DT.87043314, DT.94275211
NIA Mouse Gene Index	U038415, U302086
PDB	3AFC, 3OKW, 3OKY, 3AL8
Consensus CDS Project	CCDS37813.1
International Mouse Knockout Project Status	Sema6a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033972	VEGA Gene Model | MGI Sequence Detail	133273	C57BL/6J
transcript	OTTMUST00000085731	VEGA | MGI Sequence Detail	4339	Not Applicable
polypeptide	OTTMUSP00000046342	VEGA | MGI Sequence Detail	1048	Not Applicable

All sequences(72) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(493 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014629	semaphorin-6A

References

(Earliest) J:37600 Puschel AW, et al., The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 1996 May;7(5):419-31
(Latest) J:190960 Segarra M, et al., Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood. 2012 Nov 8;120(19):4104-15
All references(72)

Other accession IDs

MGI:2147277, MGI:2443196, MGI:5311345