Myoc
Gene Detail

Symbol Name ID

Myoc myocilin MGI:1202864

Synonyms

GLC1A, TIGR

Feature Type

protein coding gene

Genetic Map

Chromosome 1

70.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:162639150-162649693 bp, + strand From Ensembl annotation of GRCm38   10544 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Noelin/Myocilin
Gene Tree: Myoc

Human homologs

Human Homolog		MYOC, myocilin, trabecular meshwork inducible glucocorticoid response
NCBI Gene ID		4653
neXtProt AC		NX_Q99972
Human Synonyms		GLC1A, GPOA, JOAG, JOAG1, myocilin, TIGR
Human Chr (Location)		1q23-q24; chr1:171604557-171621773 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYOC

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice are viable and fertile and display no ocular abnormalities at the light and ultrastructural microscopic levels.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Component	cell projection, cilium, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (23)   
Theiler Stages: 17, 21, 28

Assay Type	Results
RNA in situ	19
Northern blot	15

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(7) cDNA(8) Primer pair(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026697 (Evidence)
Entrez Gene	17926 (Evidence)
DFCI	TC1585848, TC1720015
DoTS	DT.55144156
NIA Mouse Gene Index	U001005, U281107
Consensus CDS Project	CCDS15422.1
International Mouse Knockout Project Status	Myoc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026697	Ensembl Gene Model | MGI Sequence Detail	10544	C57BL/6J
transcript	ENSMUST00000028020	Ensembl | MGI Sequence Detail	2079	Not Applicable
polypeptide	ENSMUSP00000028020	Ensembl | MGI Sequence Detail	490	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003112	Olfactomedin-like
Protein Ontology	PR:000010873	myocilin

References

(Earliest) J:47508 Ortego J, et al., Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 1997 Aug 18;413(2):349-53
(Latest) J:184367 Joe MK, et al., Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex. J Biol Chem. 2012 Apr 13;287(16):13216-27
All references(43)

Other accession IDs

MGI:2138376