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Myoc
Gene Detail
Symbol

Name
ID
Myoc
myocilin
MGI:1202864
Synonyms
GLC1A, TIGR
Feature Type
protein coding gene
Genetic Map
Chromosome 1
70.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:162639155-162649693 bp, + strand
From VEGA annotation of GRCm38

  10539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYOC
Protein SuperFamily: Noelin/Myocilin
Gene Tree: Myoc

Human
homologs
MYOC, myocilin, trabecular meshwork inducible glucocorticoid response
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4653
neXtProt AC: NX_Q99972

Human Synonyms: GLC1A, GPOA, JOAG, JOAG1, myocilin, TIGR

Human Chr (Location): 1q23-q24; chr1:171635417-171652633 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYOC

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile and display no ocular abnormalities at the light and ultrastructural microscopic levels.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Myoc interacts with 76 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process bone development, clustering of voltage-gated sodium channels, ...
Component cell projection, cilium, ...
Function fibronectin binding, frizzled binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (34)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 15
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myoc ; ZFIN myoc    NEW 
Molecular
reagents
All nucleic(17) Genomic(7) cDNA(8) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051917 (Evidence)
Ensembl Gene Model ENSMUSG00000026697 (Evidence)
Entrez Gene 17926 (Evidence)
DFCI TC1585848, TC1720015
DoTS DT.55144156
NIA Mouse Gene Index U281107, U001005
Consensus CDS Project CCDS15422.1
International Mouse Phenotyping Consortium Status Myoc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051917 VEGA Gene Model | MGI Sequence Detail 10539 C57BL/6J ±  kb
transcript OTTMUST00000130698 VEGA | MGI Sequence Detail 2074 Not Applicable 
polypeptide OTTMUSP00000070013 VEGA | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003112 Olfactomedin-like
Protein Ontology PR:000010873 myocilin
References
(Earliest) J:47508 Ortego J, et al., Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 1997 Aug 18;413(2):349-53
(Latest) J:212429 Joe MK, et al., Myocilin regulates cell proliferation and survival. J Biol Chem. 2014 Apr 4;289(14):10155-67
All references(50)
Other
accession IDs
MGI:2138376

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory