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Myoc
Gene Detail
 Symbol
Name
ID
Myoc
myocilin
MGI:1202864
Synonyms GLC1A, TIGR
Feature Type protein coding gene
Genetic Map
Chromosome 1
70.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:162639150-162649693 bp, + strand
From Ensembl annotation of GRCm38

  10544 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Noelin/Myocilin
Gene Tree: Myoc

Human
homologs
Human Homolog MYOC, myocilin, trabecular meshwork inducible glucocorticoid response
NCBI Gene ID 4653
neXtProt AC  NX_Q99972
Human Synonyms  GLC1A, GPOA, JOAG, JOAG1, myocilin, TIGR
Human Chr (Location)  1q23-q24; chr1:171635417-171652633 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYOC
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile and display no ocular abnormalities at the light and ultrastructural microscopic levels.
 
Interactions
Myoc interacts with 76 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process bone development, clustering of voltage-gated sodium channels, ...
Component cell projection, cilium, ...
Function fibronectin binding, frizzled binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (23)   
Theiler Stages: 17, 21, 28
Assay TypeResults
RNA in situ 19
Northern blot 15
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(7) cDNA(8) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000026697 (Evidence)
Entrez Gene17926 (Evidence)
DFCITC1585848, TC1720015
DoTSDT.55144156
NIA Mouse Gene IndexU001005, U281107
Consensus CDS ProjectCCDS15422.1
International Mouse Knockout Project StatusMyoc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026697 Ensembl Gene Model | MGI Sequence Detail 10544 C57BL/6J ±  kb
transcript ENSMUST00000028020 Ensembl | MGI Sequence Detail 2079 Not Applicable 
polypeptide ENSMUSP00000028020 Ensembl | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003112 Olfactomedin-like
Protein Ontology PR:000010873 myocilin
References (Earliest) J:47508 Ortego J, et al., Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 1997 Aug 18;413(2):349-53
(Latest) J:212429 Joe MK, et al., Myocilin regulates cell proliferation and survival. J Biol Chem. 2014 Apr 4;289(14):10155-67
All references(50)
Other
accession IDs
MGI:2138376

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory