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Myoc Gene Detail
Summary
  • Symbol
    Myoc
  • Name
    myocilin
  • Synonyms
    GLC1A, TIGR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202864
    NCBI Gene: 17926
  • Gene Overview
    MyGene.info: MYOC
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:162639155-162649693 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 70.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202864
protein coding gene Chr1:162639150-162649694 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016661
protein coding gene Chr1:167981445-167991952 (+)
A/J MGP_AJ_G0016642
protein coding gene Chr1:161147679-161158256 (+)
AKR/J MGP_AKRJ_G0016608
protein coding gene Chr1:166031292-166041921 (+)
BALB/cJ MGP_BALBcJ_G0016603
protein coding gene Chr1:161675656-161686358 (+)
C3H/HeJ MGP_C3HHeJ_G0016427
protein coding gene Chr1:166236758-166247232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017064
protein coding gene Chr1:173641630-173652081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014773
protein coding gene Chr1:153198409-153209062 (+)
CAST/EiJ MGP_CASTEiJ_G0016007
protein coding gene Chr1:165888734-165899177 (+)
CBA/J MGP_CBAJ_G0016402
protein coding gene Chr1:179825673-179836147 (+)
DBA/2J MGP_DBA2J_G0016508
protein coding gene Chr1:160091373-160102163 (+)
FVB/NJ MGP_FVBNJ_G0016506
protein coding gene Chr1:158514519-158525001 (+)
LP/J MGP_LPJ_G0016579
protein coding gene Chr1:169110342-169122922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016531
protein coding gene Chr1:187329211-187345529 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017100
protein coding gene Chr1:165864803-165875303 (+)
PWK/PhJ MGP_PWKPhJ_G0015793
protein coding gene Chr1:159271772-159282361 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015580
protein coding gene Chr1:164747550-164758084 (+)
WSB/EiJ MGP_WSBEiJ_G0016069
protein coding gene Chr1:166044540-166055917 (+)



Homology
more
  • Human Ortholog
    MYOC, myocilin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYOC, myocilin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLC1A, GPOA, JOAG, JOAG1, TIGR
  • Links
    NCBI Gene ID: 4653
    neXtProt AC: NX_Q99972
    UniProt: Q99972

  • Chr Location
    1q24.3; chr1:171635417-171652633 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MYOC associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile and display no ocular abnormalities at the light and ultrastructural microscopic levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026697 Ensembl Gene Model | MGI Sequence Detail 10539 C57BL/6J ±  kb
    transcript ENSMUST00000028020 Ensembl | MGI Sequence Detail 2074 Not Applicable  
    polypeptide ENSMUSP00000028020 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 7
      cDNA 9
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138376
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:47508 Ortego J, et al., Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 1997 Aug 18;413(2):349-53
    • Latest
      J:252899 Jain A, et al., CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory