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Myoc Gene Detail
Summary
  • Symbol
    Myoc
  • Name
    myocilin
  • Synonyms
    GLC1A, TIGR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202864
    NCBI Gene: 17926
  • Gene Overview
    MyGene.info: MYOC
Location & Maps
more
  • Sequence Map
    Chr1:162639155-162649693 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10539 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 70.29 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MYOC, myocilin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYOC, myocilin
    Orthology source: HomoloGene
  • Synonyms
    GLC1A, GPOA, JOAG, JOAG1, TIGR
  • Links
    NCBI Gene ID: 4653
    neXtProt AC: NX_Q99972

  • Chr Location
    1q23-q24; chr1:171635417-171652633 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MYOC associations

Human Disease Mouse Models
       Glaucoma 1, Open Angle, A; GLC1A   OMIM: 137750 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Myoc
  • Incidental Mutations
Homozygous null mice are viable and fertile and display no ocular abnormalities at the light and ultrastructural microscopic levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051917 VEGA Gene Model | MGI Sequence Detail 10539 C57BL/6J ±  kb
transcript OTTMUST00000130698 VEGA | MGI Sequence Detail 2074 Not Applicable  
polypeptide OTTMUSP00000070013 VEGA | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    193 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 7
    cDNA 8
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138376
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Diseases 4
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:47508 Ortego J, et al., Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 1997 Aug 18;413(2):349-53
  • Latest
    J:230020 Koch MA, et al., Myocilin modulates programmed cell death during retinal development. Exp Eye Res. 2014 Aug;125:41-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory