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Gtf2i
Gene Detail
 Symbol
Name
ID
Gtf2i
general transcription factor II I
MGI:1202722
Synonyms 6030441I21Rik, BAP-135, TFII-I
Feature Type protein coding gene
Genetic Map
Chromosome 5
74.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr5:134237834-134314760 bp, - strand
From VEGA annotation of GRCm38

  76927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7748  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: general transcription factor II-I
Gene Tree: Gtf2i

Human
homologs
Human Homolog GTF2I, general transcription factor IIi
NCBI Gene ID 2969
neXtProt AC  NX_P78347
Human Synonyms  BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
Human Chr (Location)  7q11.23; chr7:74657665-74760692 (+)  GRCh38
Alleles
and
phenotypes
All alleles(157) : Targeted(7) Gene trapped(150)
 
Homozygotes for null allele is embryonic lethal, and show brain hemorrhage and neural tube defects. Although most heterozygote are normal and fertile, at low frequency, growth retardation and small head are also reported.
 
Human Diseases Modeled Using Mouse Gtf2i (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process embryo development, negative regulation of angiogenesis, ...
Component cell projection, cytoplasm, ...
Function DNA binding, mitogen-activated protein kinase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (116)    Tissues (77)    Images (19)
Theiler Stages: 2, 3, 4, 5, 6, 16, 17, 18, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 97
RT-PCR 16
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(22) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000036983 (Evidence)
Ensembl Gene ModelENSMUSG00000060261 (Evidence)
Entrez Gene14886 (Evidence)
DFCITC1573217, TC1584785, TC1590515, TC1593562, TC1596621, TC1602098, TC1609777, TC1623122, TC1654312
DoTSDT.101404752, DT.101739394, DT.102537672, DT.103571382, DT.103571391, DT.110691670, DT.55140453, DT.55265152, DT.91345415, DT.91412557, DT.94261084, DT.94356252, DT.97399290
NIA Mouse Gene IndexU026798, U146382, U214129
PDB1Q60
Consensus CDS ProjectCCDS39299.1, CCDS39300.1, CCDS39301.1, CCDS57386.1, CCDS57387.1
International Mouse Knockout Project StatusGtf2i
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036983 VEGA Gene Model | MGI Sequence Detail 76927 C57BL/6J ±  kb
transcript OTTMUST00000095068 VEGA | MGI Sequence Detail 4455 Not Applicable 
polypeptide OTTMUSP00000053008 VEGA | MGI Sequence Detail 998 Not Applicable 

For the selected sequences
All sequences(209) RefSeq(50) UniProt(9)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(795 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004212 GTF2I-like repeat
InterPro IPR016659 Transcription factor II-I
Protein Ontology PR:000008322 general transcription factor II-I
References (Earliest) J:113672 Yang W, et al., BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):604-9
(Latest) J:200765 Segura-Puimedon M, et al., TFII-I regulates target genes in the PI-3K and TGF-beta signaling pathways through a novel DNA binding motif. Gene. 2013 Sep 25;527(2):529-36
All references(71)
Other
accession IDs
MGI:2149785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory