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Mmp8
Gene Detail
 Symbol
Name
ID
Mmp8
matrix metallopeptidase 8
MGI:1202395
Synonyms Collagenase-2
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7558429-7568486 bp, + strand
From NCBI annotation of GRCm38

  10058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp8

Human
homologs
Human Homolog MMP8, matrix metallopeptidase 8 (neutrophil collagenase)
NCBI Gene ID 4317
neXtProt AC  NX_P22894
Human Synonyms  CLG1, HNC, MMP-8, PMNL-CL
Human Chr (Location)  11q22.3; chr11:102711795-102724954 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males, and to a lesser extent ovariectomized or tamoxifen-treated null females, show increased susceptibility to chemically-induced skin tumors, a sustained inflammatory response to carcinogens, and increased PMN burden in the alveolar space during LPS-mediated acute lung injury.
 
Interactions
Mmp8 interacts with 170 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process collagen catabolic process, proteolysis
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (185)    Tissues (34)    Images (47)
Theiler Stages: 20, 23, 25, 26, 28
Assay TypeResults
RNA in situ 157
Northern blot 21
RT-PCR 7
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(3) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000005800 (Evidence)
Entrez Gene17394 (Evidence)
DFCITC1573808
DoTSDT.101406748, DT.55171320, DT.91298551
NIA Mouse Gene IndexU054668
EC3.4.24.34
Consensus CDS ProjectCCDS22808.1
International Mouse Knockout Project StatusMmp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17394 NCBI Gene Model | MGI Sequence Detail 10058 C57BL/6J ±  kb
transcript NM_008611 RefSeq | MGI Sequence Detail 2453 C57BL/6 
polypeptide O70138 UniProt | EBI | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010490 neutrophil collagenase
Graphical View of Protein Domain Structure
References (Earliest) J:46612 Lawson ND, et al., Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 1998 Apr 1;91(7):2517-24
(Latest) J:211445 Fang C, et al., An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. Cardiovasc Res. 2013 Jul 1;99(1):146-55
All references(70)
Other
accession IDs
MGI:2143366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory