Mmp8
Gene Detail

Symbol Name ID

Mmp8 matrix metallopeptidase 8 MGI:1202395

Synonyms

Collagenase-2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:7558429-7568486 bp, + strand From NCBI annotation of GRCm38   10058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp8

Human homologs

Human Homolog		MMP8, matrix metallopeptidase 8 (neutrophil collagenase)
NCBI Gene ID		4317
neXtProt AC		NX_P22894
Human Synonyms		CLG1, HNC, MMP-8, PMNL-CL
Human Chr (Location)		11q22.3; chr11:102582526-102595685 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null males, and to a lesser extent ovariectomized or tamoxifen-treated null females, show increased susceptibility to chemically-induced skin tumors, a sustained inflammatory response to carcinogens, and increased PMN burden in the alveolar space during LPS-mediated acute lung injury.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	collagen catabolic process, proteolysis
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (185)    Tissues (34)    Images (47)
Theiler Stages: 20, 23, 25, 26, 28

Assay Type	Results
RNA in situ	157
Northern blot	21
RT-PCR	7

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(3) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000005800 (Evidence)
Entrez Gene	17394 (Evidence)
DFCI	TC1573808
DoTS	DT.101406748, DT.55171320, DT.91298551
NIA Mouse Gene Index	U054668
EC	3.4.24.34
Consensus CDS Project	CCDS22808.1
International Mouse Knockout Project Status	Mmp8

Sequences

Length	Strain/Species
genomic	17394	NCBI Gene Model | MGI Sequence Detail	10058	C57BL/6J
transcript	NM_008611	RefSeq | MGI Sequence Detail	2453	C57BL/6
polypeptide	O70138	UniProt | EBI | MGI Sequence Detail	465	Not Applicable

All sequences(38) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR016293	Peptidase M10A, metazoans
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010490	neutrophil collagenase

Graphical View of Protein Domain Structure

References

(Earliest) J:46612 Lawson ND, et al., Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 1998 Apr 1;91(7):2517-24
(Latest) J:187906 Gonzalez-Lopez A, et al., MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia. PLoS One. 2012;7(6):e39940
All references(66)

Other accession IDs

MGI:2143366