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Mmp8 Gene Detail
Summary
  • Symbol
    Mmp8
  • Name
    matrix metallopeptidase 8
  • Synonyms
    Collagenase-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202395
    NCBI Gene: 17394
  • Gene Overview
    MyGene.info: MMP8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:7558456-7568485 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10030 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MMP8, matrix metallopeptidase 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MMP8, matrix metallopeptidase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLG1, HNC, MMP-8, PMNL-CL
  • Links
    NCBI Gene ID: 4317
    neXtProt AC: NX_P22894
    UniProt: P22894

  • Chr Location
    11q22.2; chr11:102711795-102724967 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null males, and to a lesser extent ovariectomized or tamoxifen-treated null females, show increased susceptibility to chemically-induced skin tumors, a sustained inflammatory response to carcinogens, and increased PMN burden in the alveolar space during LPS-mediated acute lung injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005800 Ensembl Gene Model | MGI Sequence Detail 10030 C57BL/6J ±  kb
    transcript ENSMUST00000018765 Ensembl | MGI Sequence Detail 2425 Not Applicable  
    polypeptide ENSMUSP00000018765 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      114 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143366
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 16
      Gene Ontology 5
      Phenotypes 39
    • Earliest
      J:46612 Lawson ND, et al., Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 1998 Apr 1;91(7):2517-24
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory