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Gnmt
Gene Detail
 Symbol
Name
ID
Gnmt
glycine N-methyltransferase
MGI:1202304
Synonyms glycine N methyl transferase
Feature Type protein coding gene
Genetic Map
Chromosome 17
22.90 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:46725664-46729168 bp, - strand
From VEGA annotation of GRCm38

  3505 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7741  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: glycine N-methyltransferase
Gene Tree: Gnmt

Human
homologs
Human Homolog GNMT, glycine N-methyltransferase
NCBI Gene ID 27232
neXtProt AC  NX_Q14749
Human Chr (Location)  6p12; chr6:42960762-42963880 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNMT
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma.
 
Human Diseases Modeled Using Mouse Gnmt (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Gnmt interacts with 3 markers (Mir20a, Mir1950, Mir3062)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process glycogen metabolic process, methionine metabolic process, ...
Component cytoplasm
Function folic acid binding, glycine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (124)    Tissues (108)    Images (8)
Theiler Stages: 11, 15, 20, 21, 22, 26, 28
Assay TypeResults
RNA in situ 95
Western blot 6
RT-PCR 23
cDNA source data(129)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(135) cDNA(130) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026384 (Evidence)
Ensembl Gene ModelENSMUSG00000002769 (Evidence)
Entrez Gene14711 (Evidence)
UniGene29395
DFCITC1575679
DoTSDT.55100232
NIA Mouse Gene IndexU037867
EC2.1.1.20
PDB1R8X, 1R8Y
Consensus CDS ProjectCCDS28838.1
International Mouse Knockout Project StatusGnmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026384 VEGA Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
transcript OTTMUST00000065249 VEGA | MGI Sequence Detail 1035 Not Applicable 
polypeptide OTTMUSP00000032495 VEGA | MGI Sequence Detail 293 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014369 Glycine/Sarcosine N-methyltransferase
InterPro IPR025714 Methyltransferase domain
Protein Ontology PR:000008120 glycine N-methyltransferase
References (Earliest) J:46123 Aida K, et al., Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997 Dec;29(12):646-9
(Latest) J:171573 Yoon H, et al., Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol. 2011 Mar;44(1):69-78
All references(40)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory