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Gnmt Gene Detail
Summary
  • Symbol
    Gnmt
  • Name
    glycine N-methyltransferase
  • Synonyms
    glycine N methyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202304
    NCBI Gene: 14711
  • Gene Overview
    MyGene.info: GNMT
Location & Maps
more
  • Sequence Map
    Chr17:46725664-46729168 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3505 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GNMT, glycine N-methyltransferase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GNMT, glycine N-methyltransferase
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-182mP
  • Links
    NCBI Gene ID: 27232
    neXtProt AC: NX_Q14749

  • Chr Location
    6p12; chr6:42939415-42963880 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Gnmt mouse models; 1 with human GNMT associations

Human Disease Mouse Models
       Glycine N-Methyltransferase Deficiency   OMIM: 606664 View 2 models
       Hepatocellular Carcinoma   OMIM: 114550 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026384 VEGA Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
transcript OTTMUST00000065249 VEGA | MGI Sequence Detail 1035 Not Applicable  
polypeptide OTTMUSP00000032495 VEGA | MGI Sequence Detail 293 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 135
    cDNA 130
    Primer pair 5

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:46123 Aida K, et al., Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997 Dec;29(12):646-9
  • Latest
    J:222874 Liao YJ, et al., Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. Int J Cancer. 2015 Sep;137(6):1341-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory