Gnmt
Gene Detail

Symbol Name ID

Gnmt glycine N-methyltransferase MGI:1202304

Synonyms

glycine N methyl transferase

Feature Type

protein coding gene

Genetic Map

Chromosome 17

22.90 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:46725664-46729168 bp, - strand From VEGA annotation of GRCm38   3505 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycine N-methyltransferase
Gene Tree: Gnmt

Human homologs

Human Homolog		GNMT, glycine N-methyltransferase
NCBI Gene ID		27232
neXtProt AC		NX_Q14749
Human Chr (Location)		6p12; chr6:42928500-42931618 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GNMT

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null mutation display elevated levels of methionine and S-adenosylmethionine in the liver. Mice homozygous for another null allele exhibit hepatitis, increased hepatic glycogen storage, and hepatocellular carcinoma.

 
Human Diseases Modeled Using Mouse Gnmt (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	glycine metabolic process, glycogen metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	folic acid binding, glycine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (124)    Tissues (108)    Images (8)
Theiler Stages: 11, 15, 20, 21, 22, 26, 28

Assay Type	Results
RNA in situ	95
Western blot	6
RT-PCR	23

cDNA source data(129)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(135) cDNA(130) Primer pair(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026384 (Evidence)
Ensembl Gene Model	ENSMUSG00000002769 (Evidence)
Entrez Gene	14711 (Evidence)
UniGene	29395
DFCI	TC1575679
DoTS	DT.55100232
NIA Mouse Gene Index	U037867
EC	2.1.1.20
PDB	1R8X, 1R8Y
Consensus CDS Project	CCDS28838.1
International Mouse Knockout Project Status	Gnmt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026384	VEGA Gene Model | MGI Sequence Detail	3505	C57BL/6J
transcript	OTTMUST00000065249	VEGA | MGI Sequence Detail	1035	Not Applicable
polypeptide	OTTMUSP00000032495	VEGA | MGI Sequence Detail	293	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014369	Glycine/Sarcosine N-methyltransferase
Protein Ontology	PR:000008120	glycine N-methyltransferase

References

(Earliest) J:46123 Aida K, et al., Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997 Dec;29(12):646-9
(Latest) J:171573 Yoon H, et al., Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol. 2011 Mar;44(1):69-78
All references(41)