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Chek1
Gene Detail
Symbol

Name
ID
Chek1
checkpoint kinase 1
MGI:1202065
Synonyms
Chk1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.67 cM, cytoband A5.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:36708482-36727065 bp, - strand
From VEGA annotation of GRCm38

  18584 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:975  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chek1

Human
homologs
Human Homolog CHEK1, checkpoint kinase 1
NCBI Gene ID 1111
neXtProt AC  NX_O14757
Human Synonyms  CHK1
Human Chr (Location)  11q24.2; chr11:125625136-125676255 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(20) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display embryonic lethality between E2.5 and E7.5, impaired cell cycle checkpoint function, increase in blastocyst apoptosis and lack of inner cell mass proliferation.
 
Interactions
Chek1 interacts with 286 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component centrosome, chromatin, ...
Function ATP binding, histone kinase activity (H3-T11 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (22)    Tissues (21)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 15
RT-PCR 7
cDNA source data(128)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(131) cDNA(128) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000037031 (Evidence)
Ensembl Gene ModelENSMUSG00000032113 (Evidence)
Entrez Gene12649 (Evidence)
UniGene16753
DFCITC1649135, TC1574581
DoTSDT.101403186, DT.97413354, DT.492274, DT.101737888
NIA Mouse Gene IndexU030680
EC2.7.11.1
Consensus CDS ProjectCCDS22972.1
International Mouse Knockout Project StatusChek1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037031 VEGA Gene Model | MGI Sequence Detail 18584 C57BL/6J ±  kb
transcript OTTMUST00000095239 VEGA | MGI Sequence Detail 3797 Not Applicable 
polypeptide OTTMUSP00000053133 VEGA | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(11)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005417 serine/threonine-protein kinase Chk1
References
(Earliest) J:42767 Sanchez Y, et al., Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 [see comments]. Science. 1997 Sep 5;277(5331):1497-501
(Latest) J:213044 Greenow KR, et al., Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene. 2014 Jul 31;33(31):4089-96
All references(80)
Other
accession IDs
MGI:2143427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory