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Tapbp
Gene Detail
Symbol

Name
ID
Tapbp
TAP binding protein
MGI:1201689
Synonyms
D17Wsu91e, tapasin, TPN
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:33915899-33929288 bp, + strand
From VEGA annotation of GRCm38

  13390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TAPBP
Gene Tree: Tapbp

Human
homologs
TAPBP, TAP binding protein (tapasin)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6892
neXtProt AC: NX_O15533

Human Synonyms: NGS17, TAPA, TPN, TPSN

Human Chr (Location): 6p21.3; chr6:33299694-33314387 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TAPBP

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to reduced and thermolabile MHC class I surface expression due to impaired peptide loading with stabilizing peptides, impaired T cell selection, altered NK repertoire, lower CD8+ T cell numbers, and impaired responses to select class I-restricted antigens.
 
Interactions
Tapbp interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (74)    Tissues (28)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 59
RT-PCR 15
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tapbp ; ZFIN tapbp    NEW 
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(21) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037070 (Evidence)
Ensembl Gene Model ENSMUSG00000024308 (Evidence)
Entrez Gene 21356 (Evidence)
DFCI TC1710572, TC1573350
DoTS DT.55101099, DT.101388814, DT.91358287, DT.97384886
Consensus CDS Project CCDS37572.1
International Mouse Phenotyping Consortium Status Tapbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037070 VEGA Gene Model | MGI Sequence Detail 13390 C57BL/6J ±  kb
transcript OTTMUST00000095370 VEGA | MGI Sequence Detail 2894 Not Applicable 
polypeptide OTTMUSP00000053220 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(17)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR008056 Tapasin
Protein Ontology PR:000016053 tapasin
References
(Earliest) J:46195 Herberg JA, et al., Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Eur J Immunol. 1998 Feb;28(2):459-67
(Latest) J:205830 Kanaseki T, et al., ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol. 2013 Aug 15;191(4):1547-55
All references(64)
Other
accession IDs
MGD-MRK-33974, MGI:106282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory