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Tapbp
Gene Detail
 Symbol
Name
ID
Tapbp
TAP binding protein
MGI:1201689
Synonyms D17Wsu91e, tapasin, TPN
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr17:33915899-33929288 bp, + strand
From VEGA annotation of GRCm38

  13390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2401  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Tapbp

Human
homologs
Human Homolog TAPBP, TAP binding protein (tapasin)
NCBI Gene ID 6892
neXtProt AC  NX_O15533
Human Synonyms  NGS17, TAPA, TPN, TPSN
Human Chr (Location)  6p21.3; chr6:33299694-33314387 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TAPBP
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Gene trapped(1)
 
Homozygous inactivation of this gene leads to reduced and thermolabile MHC class I surface expression due to impaired peptide loading with stabilizing peptides, impaired T cell selection, altered NK repertoire, lower CD8+ T cell numbers, and impaired responses to select class I-restricted antigens.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function TAP1 binding, TAP2 binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (74)    Tissues (27)    Images (35)
Theiler Stages: 9, 11, 12, 16, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 59
RT-PCR 15
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(21) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037070 (Evidence)
Ensembl Gene ModelENSMUSG00000024308 (Evidence)
Entrez Gene21356 (Evidence)
DFCITC1573350, TC1710572
DoTSDT.101388814, DT.55101099, DT.91358287, DT.97384886
Consensus CDS ProjectCCDS37572.1
International Mouse Knockout Project StatusTapbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037070 VEGA Gene Model | MGI Sequence Detail 13390 C57BL/6J ±  kb
transcript OTTMUST00000095370 VEGA | MGI Sequence Detail 2894 Not Applicable 
polypeptide OTTMUSP00000053220 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(4) UniProt(17)
Polymorphisms SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR008056 Tapasin
Protein Ontology PR:000016053 tapasin
References (Earliest) J:46195 Herberg JA, et al., Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Eur J Immunol. 1998 Feb;28(2):459-67
(Latest) J:205830 Kanaseki T, et al., ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol. 2013 Aug 15;191(4):1547-55
All references(64)
Other
accession IDs
MGD-MRK-33974, MGI:106282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory