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Tapbp Gene Detail
Summary
  • Symbol
    Tapbp
  • Name
    TAP binding protein
  • Synonyms
    D17Wsu91e, tapasin, TPN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201689
    NCBI Gene: 21356
  • Gene Overview
    MyGene.info: TAPBP
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33919478-33929290 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201689
protein coding gene Chr17:33915899-33929290 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023542
protein coding gene Chr17:33865165-33878384 (+)
A/J MGP_AJ_G0023503
protein coding gene Chr17:32698420-32711814 (+)
AKR/J MGP_AKRJ_G0023469
protein coding gene Chr17:33094077-33107451 (+)
BALB/cJ MGP_BALBcJ_G0023506
protein coding gene Chr17:32871375-32884905 (+)
C3H/HeJ MGP_C3HHeJ_G0023268
protein coding gene Chr17:33449435-33462825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023949
protein coding gene Chr17:35122040-35131950 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021422
protein coding gene Chr17:30200612-30214552 (+)
CAST/EiJ MGP_CASTEiJ_G0022770
protein coding gene Chr17:33520584-33536743 (+)
CBA/J MGP_CBAJ_G0023245
protein coding gene Chr17:36547516-36560830 (+)
DBA/2J MGP_DBA2J_G0023373
protein coding gene Chr17:32075997-32089278 (+)
FVB/NJ MGP_FVBNJ_G0023342
protein coding gene Chr17:31935259-31948634 (+)
LP/J MGP_LPJ_G0023451
protein coding gene Chr17:34139890-34154067 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023364
protein coding gene Chr17:35599908-35613318 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023989
protein coding gene Chr17:33420155-33435621 (+)
PWK/PhJ MGP_PWKPhJ_G0022518
protein coding gene Chr17:30989211-31003458 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022334
protein coding gene Chr17:31382326-31397623 (+)
WSB/EiJ MGP_WSBEiJ_G0022830
protein coding gene Chr17:33460197-33473486 (+)



Homology
more
  • Human Ortholog
    TAPBP, TAP binding protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TAPBP, TAP binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NGS17, TAPA, TPN, TPSN
  • Links
    NCBI Gene ID: 6892
    neXtProt AC: NX_O15533
    UniProt: O15533

  • Chr Location
    6p21.32; chr6:33299694-33314387 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2401
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TAPBP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TAPBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced and thermolabile MHC class I surface expression due to impaired peptide loading with stabilizing peptides, impaired T cell selection, altered NK repertoire, lower CD8+ T cell numbers, and impaired responses to select class I-restricted antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21356 NCBI Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
transcript NM_001025313 RefSeq | MGI Sequence Detail 2750 C57BL/6  
polypeptide Q9R233 UniProt | EBI | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    17 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR008056 Tapasin
Molecular
Reagents
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  • All nucleic 29
    Genomic 4
    cDNA 23
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33974, MGI:106282
References
more
  • Summaries
    All 61
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:46195 Herberg JA, et al., Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Eur J Immunol. 1998 Feb;28(2):459-67
  • Latest
    J:205830 Kanaseki T, et al., ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol. 2013 Aug 15;191(4):1547-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory