Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including MHC class I protein complex binding activity; TAP binding activity; and TAP complex binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and peptide antigen stabilization. Acts upstream of or within defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of Tapasin-ERp57 complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in MHC class I deficiency and severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein).