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Ctbp1
Gene Detail
 Symbol
Name
ID
Ctbp1
C-terminal binding protein 1
MGI:1201685
Synonyms BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.52 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:33247724-33275004 bp, - strand
From Ensembl annotation of GRCm38

  27281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1015  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Ctbp1

Human
homologs
Human Homolog CTBP1, C-terminal binding protein 1
NCBI Gene ID 1487
neXtProt AC  NX_Q13363
Human Synonyms  BARS
Human Chr (Location)  4p16; chr4:1211440-1249120 (-)  GRCh38
Alleles
and
phenotypes
All alleles(12) : Gene trapped(11) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display partial postnatal lethality and decreased body size.
 
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process cell differentiation, Golgi organization, ...
Component cytoplasm, cytosol, ...
Function 2-hydroxytetrahydrofuran dehydrogenase activity, 3-hydroxymenthone dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (30)    Images (1)
Theiler Stages: 15, 17, 19, 20, 28
Assay TypeResults
RNA in situ 21
Northern blot 10
cDNA source data(208)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(210) cDNA(210)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037373 (Evidence)
Entrez Gene13016 (Evidence)
UniGene7286
DFCITC1572443
DoTSDT.101399082, DT.110656934, DT.94340736, DT.94355083, DT.94355084, DT.99862694
NIA Mouse Gene IndexU026084
EC1.1.1.-
Consensus CDS ProjectCCDS19201.1
International Mouse Knockout Project StatusCtbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037373 Ensembl Gene Model | MGI Sequence Detail 27281 C57BL/6J ±  kb
transcript ENSMUST00000079746 Ensembl | MGI Sequence Detail 2288 Not Applicable 
polypeptide ENSMUSP00000078682 Ensembl | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(1)
Polymorphisms RFLP(6) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000005994 C-terminal-binding protein 1
References (Earliest) J:496 Koizumi T, et al., Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Mamm Genome. 1992;3(1):23-7
(Latest) J:201927 Vaithianathan T, et al., The ribbon-associated protein C-terminal-binding protein 1 is not essential for the structure and function of retinal ribbon synapses. Mol Vis. 2013;19:917-26
All references(64)
Other
accession IDs
MGD-MRK-16717, MGD-MRK-6985, MGD-MRK-7054, MGI:93155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory