About   Help   FAQ
Ctbp1
Gene Detail
Symbol

Name
ID
Ctbp1
C-terminal binding protein 1
MGI:1201685
Synonyms
BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.52 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:33247723-33274994 bp, - strand
From VEGA annotation of GRCm38

  27272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1015  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTBP1
Protein SuperFamily: phosphoglycerate dehydrogenase
Gene Tree: Ctbp1

Human
homologs
CTBP1, C-terminal binding protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1487
neXtProt AC: NX_Q13363

Human Synonyms: BARS

Human Chr (Location): 4p16; chr4:1211440-1250248 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTBP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(11) Radiation induced(3) Targeted(1)
Genomic Mutations involving Ctbp1 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display partial postnatal lethality and decreased body size.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Ctbp1 interacts with 123 markers (Mir7-1, Mir23a, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process cell differentiation, metabolic process, ...
Component cytoplasm, nucleoplasm, ...
Function 2-hydroxytetrahydrofuran dehydrogenase activity, 3-hydroxymenthone dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (30)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
Northern blot 10
cDNA source data(208)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CTBP1 ; Xenbase ctbp1 ; ZFIN ctbp1    NEW 
Molecular
reagents
All nucleic(210) cDNA(210)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000055360 (Evidence)
Ensembl Gene Model ENSMUSG00000037373 (Evidence)
Entrez Gene 13016 (Evidence)
UniGene 7286
DFCI TC1572443
DoTS DT.101399082, DT.110656934, DT.94340736, DT.94355083, DT.94355084, DT.99862694
NIA Mouse Gene Index U026084
EC 1.1.1.-
Consensus CDS Project CCDS19201.1, CCDS80255.1, CCDS80256.1
International Mouse Phenotyping Consortium Status Ctbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055360 VEGA Gene Model | MGI Sequence Detail 27272 C57BL/6J ±  kb
transcript OTTMUST00000137055 VEGA | MGI Sequence Detail 2279 Not Applicable 
polypeptide OTTMUSP00000072233 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(6) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
InterPro IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
InterPro IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000005994 C-terminal-binding protein 1
References
(Earliest) J:496 Koizumi T, et al., Linkage, but not gene order, of homologous loci, including alpha-L-iduronidase (Idua), is conserved in the Huntington disease region of the mouse and human genomes. Mamm Genome. 1992;3(1):23-7
(Latest) J:208077 Deng H, et al., CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis. J Invest Dermatol. 2014 May;134(5):1323-31
All references(66)
Other
accession IDs
MGD-MRK-16717, MGD-MRK-6985, MGD-MRK-7054, MGI:93155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory