Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and chromatin binding activity. Involved in negative regulation of DNA-templated transcription; synaptic vesicle cycle; and white fat cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; limb; lung; and neural retina. Orthologous to human CTBP1 (C-terminal binding protein 1).