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Cxadr Gene Detail
Summary
  • Symbol
    Cxadr
  • Name
    coxsackie virus and adenovirus receptor
  • Synonyms
    2610206D03Rik, CAR, MCAR, MCVADR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201679
    NCBI Gene: 13052
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:78301496-78359785 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58290 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 45.28 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CXADR, CXADR, Ig-like cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CXADR, CXADR, Ig-like cell adhesion molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAR, CAR4/6, HCAR
  • Links
    NCBI Gene ID: 1525
    neXtProt AC: NX_P78310
    UniProt: P78310

  • Chr Location
    21q21.1; chr21:17512906-17636213 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1024
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CXADR
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 9 alleles in 11 genetic backgrounds
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014961 VEGA Gene Model | MGI Sequence Detail 58290 C57BL/6J ±  kb
    transcript OTTMUST00000035518 VEGA | MGI Sequence Detail 5734 Not Applicable  
    polypeptide OTTMUSP00000015903 VEGA | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      259 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      Genomic 1
      cDNA 186
      Primer pair 11

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1917696, MGI:2146546, MGI:2146662
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 17
      Phenotypes 36
    • Earliest
      J:51751 Tomko RP, et al., HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6
    • Latest
      J:242574 Spranger S, et al., Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017 May 08;31(5):711-723.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory