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Cxadr Gene Detail
Summary
  • Symbol
    Cxadr
  • Name
    coxsackie virus and adenovirus receptor
  • Synonyms
    2610206D03Rik, CAR, MCAR, MCVADR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201679
    NCBI Gene: 13052
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:78301489-78359774 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 45.28 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201679
protein coding gene Chr16:78301459-78359785 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022960
protein coding gene Chr16:78461491-78519279 (+)
A/J MGP_AJ_G0022928
protein coding gene Chr16:75009487-75060638 (+)
AKR/J MGP_AKRJ_G0022898
protein coding gene Chr16:77259677-77315014 (+)
BALB/cJ MGP_BALBcJ_G0022930
protein coding gene Chr16:75407397-75463324 (+)
C3H/HeJ MGP_C3HHeJ_G0022692
protein coding gene Chr16:77706795-77759057 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023378
protein coding gene Chr16:80993695-81050346 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020881
protein coding gene Chr16:73437359-73488074 (+)
CAST/EiJ MGP_CASTEiJ_G0022214
protein coding gene Chr16:78114763-78168000 (+)
CBA/J MGP_CBAJ_G0022662
protein coding gene Chr16:84428828-84485339 (+)
DBA/2J MGP_DBA2J_G0022795
protein coding gene Chr16:74844026-74895547 (+)
FVB/NJ MGP_FVBNJ_G0022770
protein coding gene Chr16:74189587-74240817 (+)
LP/J MGP_LPJ_G0022864
protein coding gene Chr16:78200637-78253575 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022789
protein coding gene Chr16:87682509-87738511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023395
protein coding gene Chr16:77579810-77632471 (+)
PWK/PhJ MGP_PWKPhJ_G0021956
protein coding gene Chr16:75049937-75101952 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021786
protein coding gene Chr16:77263147-77320610 (+)
WSB/EiJ MGP_WSBEiJ_G0022262
protein coding gene Chr16:77824033-77878242 (+)



Homology
more
  • Human Ortholog
    CXADR, CXADR, Ig-like cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CXADR, CXADR, Ig-like cell adhesion molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAR, CAR4/6, HCAR
  • Links
    NCBI Gene ID: 1525
    neXtProt AC: NX_P78310
    UniProt: P78310

  • Chr Location
    21q21.1; chr21:17512906-17636213 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1024
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CXADR
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 9 alleles in 11 genetic backgrounds
    3 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022865 Ensembl Gene Model | MGI Sequence Detail 58286 C57BL/6J ±  kb
    transcript ENSMUST00000023572 Ensembl | MGI Sequence Detail 5742 Not Applicable  
    polypeptide ENSMUSP00000023572 Ensembl | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 202
      Genomic 1
      cDNA 188
      Primer pair 12
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1917696, MGI:2146546, MGI:2146662
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 17
      Phenotypes 40
    • Earliest
      J:51751 Tomko RP, et al., HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory