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Cxadr Gene Detail
Summary
  • Symbol
    Cxadr
  • Name
    coxsackie virus and adenovirus receptor
  • Synonyms
    2610206D03Rik, CAR, MCAR, MCVADR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201679
    NCBI Gene: 13052
Location & Maps
more
  • Sequence Map
    Chr16:78301496-78359785 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58290 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CXADR, coxsackie virus and adenovirus receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CXADR, coxsackie virus and adenovirus receptor
    Orthology source: HomoloGene
  • Synonyms
    CAR, CAR4/6, HCAR
  • Links
    NCBI Gene ID: 1525
    neXtProt AC: NX_P78310

  • Chr Location
    21q21.1; chr21:17512906-17633323 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1024
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CXADR
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 9 alleles in 11 genetic backgrounds
    3 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    3
  • Targeted
    14
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cxadr
  • Incidental Mutations
Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014961 VEGA Gene Model | MGI Sequence Detail 58290 C57BL/6J ±  kb
transcript OTTMUST00000035518 VEGA | MGI Sequence Detail 5734 Not Applicable  
polypeptide OTTMUSP00000015903 VEGA | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    259 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 189
    Genomic 1
    cDNA 186
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
less
MGI:1917696, MGI:2146546, MGI:2146662
References
more
  • Summaries
    All 66
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 17
    Phenotypes 31
  • Earliest
    J:51751 Tomko RP, et al., HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6
  • Latest
    J:229770 Clausen BE, et al., Surmounting limited gene delivery into primary immune cell populations: Efficient cell type-specific adenoviral transduction by CAR. Eur J Immunol. 2015 Jun;45(6):1596-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory