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Cxadr
Gene Detail
Symbol

Name
ID
Cxadr
coxsackie virus and adenovirus receptor
MGI:1201679
Synonyms
2610206D03Rik, CAR, MCAR, MCVADR
Feature Type
protein coding gene
Genetic Map
Chromosome 16
45.28 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:78301496-78359785 bp, + strand
From VEGA annotation of GRCm38

  58290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cxadr

Human
homologs
Human Homolog CXADR, coxsackie virus and adenovirus receptor
NCBI Gene ID 1525
neXtProt AC  NX_P78310
Human Synonyms  CAR, CAR4/6, HCAR
Human Chr (Location)  21q21.1; chr21:17512906-17593579 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(3) Targeted(12)
Genomic Mutations involving Cxadr (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality with focal cardiomyocyte apoptosis and extensive thoracic hemorrhaging.
 
Phenotype Images(3)
Interactions
Cxadr interacts with 388 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (546)    Tissues (159)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 516
RT-PCR 18
cDNA source data(186)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(189) Genomic(1) cDNA(186) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000014961 (Evidence)
Ensembl Gene ModelENSMUSG00000022865 (Evidence)
Entrez Gene13052 (Evidence)
UniGene66222
DFCITC1594408, TC1607528, TC1577885, TC1588799, TC1629874, TC1635120
PDB3MJ7, 3JZ7
Consensus CDS ProjectCCDS28276.1, CCDS37379.1
International Mouse Knockout Project StatusCxadr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014961 VEGA Gene Model | MGI Sequence Detail 58290 C57BL/6J ±  kb
transcript OTTMUST00000035518 VEGA | MGI Sequence Detail 5734 Not Applicable 
polypeptide OTTMUSP00000015903 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000006062 coxsackievirus and adenovirus receptor
References
(Earliest) J:51751 Tomko RP, et al., HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6
(Latest) J:212422 Sultana T, et al., Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier. Reproduction. 2014 Jun;147(6):875-83
All references(65)
Other
accession IDs
MGI:1917696, MGI:2146546, MGI:2146662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory