66 phenotypes from 10 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cxadrem1(IMPC)Mbp/Cxadr+ C57BL/6N-Cxadrem1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal stomach morphology	J:211773
	small kidney	J:211773
	small spleen	J:211773
Cxadrem1(IMPC)Mbp/Cxadrem1(IMPC)Mbp C57BL/6N-Cxadrem1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal neural tube morphology	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Cxadrtm1.1Ics/Cxadrtm1.1Ics Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA	abnormal exocrine pancreas morphology	J:174138
	abnormal intercalated disk morphology	J:174138
	abnormal intestine morphology	J:174138
	abnormal pancreas morphology	J:174138
	abnormal response to new environment	J:174138
	atrioventricular block	J:174138
	decreased pancreatic acinar cell number	J:174138
	enlarged thymus	J:174138
	exocrine pancreas atrophy	J:174138
	increased thymocyte number	J:174138
	pancreatic acinar-to-ductal metaplasia	J:174138
	small pancreas	J:174138
Cxadrtm1.1Mds/Cxadrtm1.1Mds involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	abnormal cardinal vein morphology	J:121400
	abnormal fetal cardiomyocyte proliferation	J:121400
	abnormal heart left ventricle morphology	J:121400
	abnormal heart tube morphology	J:121400
	abnormal heart valve morphology	J:121400
	abnormal myocardial fiber morphology	J:121400
	abnormal myocardium layer morphology	J:121400
	normal cardiovascular system phenotype	J:121400
	normal embryo phenotype	J:121400
	embryonic lethality during organogenesis, complete penetrance	J:121400
	heart hyperplasia	J:121400
Cxadrtm1Dvst/Cxadrtm1Dvst involves: 129X1/SvJ * C57BL/6	abnormal cardinal vein morphology	J:100174
	abnormal fetal atrioventricular canal morphology	J:100174
	abnormal heart ventricle morphology	J:100174
	abnormal mitochondrial morphology	J:100174
	abnormal myocardial fiber morphology	J:100174
	abnormal placental labyrinth vasculature morphology	J:100174
	abnormal sarcomere morphology	J:100174
	decreased myocardial fiber size	J:100174
	dilated dorsal aorta	J:100174
	embryonic lethality during organogenesis, complete penetrance	J:100174
	enlarged pericardium	J:100174
	increased atrioventricular cushion size	J:100174
	increased cardiac muscle glycogen level	J:100174
	pericardial edema	J:100174
Cxadrtm1Know/Cxadrtm1Know Tg(Myh6-cre)2182Mds/0 involves: 129 * Black Swiss * FVB/N	abnormal intercalated disk morphology	J:140870
	absent P wave	J:140870
	atrioventricular block	J:140870
	cardiac fibrosis	J:140870
	decreased cardiac muscle contractility	J:140870
	prolonged PR interval	J:140870
	shortened RR interval	J:140870
Cxadrtm1Mds/Cxadrtm1.1Mds Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal heart ventricle morphology	J:121400
	abnormal sinoatrial valve morphology	J:121400
	normal mortality/aging	J:121400
Cxadrtm1Mds/Cxadrtm1.1Mds Tg(Tnnt2-cre)5Blh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal cardinal vein morphology	J:121400
	abnormal heart tube morphology	J:121400
	absent sinoatrial valve	J:121400
	embryonic lethality during organogenesis, complete penetrance	J:121400
Cxadrtm1Mds/Cxadrtm1Mds Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal heart ventricle morphology	J:121400
	abnormal sinoatrial valve morphology	J:121400
	normal mortality/aging	J:121400
Cxadrtm1Mds/Cxadrtm1Mds Tg(Tnnt2-cre)5Blh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal cardinal vein morphology	J:121400
	abnormal heart tube morphology	J:121400
	absent sinoatrial valve	J:121400
	embryonic lethality during organogenesis, complete penetrance	J:121400
Cxadrtm1Mgot/Cxadrtm1Mgot A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ involves: FVB	abnormal atrioventricular node conduction	J:140109
	abnormal atrioventricular node morphology	J:140109
	increased heart rate variability	J:140109
	prolonged PR interval	J:140109
Cxadrtm1Mgot/Cxadrtm1Mgot Tg(Myh6-cre)2182Mds/0 involves: FVB/N	embryonic lethality during organogenesis, complete penetrance	J:140109
Cxadrtm1Rwf/Cxadrtm1Rwf involves: 129S6/SvEvTac * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:99585
	hemopericardium	J:99585
	hemothorax	J:99585
	increased cardiomyocyte apoptosis	J:99585
	thin myocardium	J:99585
Cxadrtm2Know/Cxadr+ involves: 129 * Black Swiss	abnormal heart electrocardiography waveform feature	J:140870
Cxadrtm2Know/Cxadrtm2Know involves: 129 * Black Swiss	abnormal heart electrocardiography waveform feature	J:140870
	absent heartbeat	J:140870
	embryonic lethality during organogenesis, complete penetrance	J:140870
	pericardial effusion	J:140870
Tg(Lck-Cxadr)1Jdgr/0 FVB-Tg(Lck-Cxadr)1Jdgr	abnormal T cell physiology	J:109884
	decreased T cell apoptosis	J:109884
	decreased T cell proliferation	J:109884