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Cxadrtm1.1Ics
Targeted Allele Detail
Summary
Symbol: Cxadrtm1.1Ics
Name: coxsackie virus and adenovirus receptor; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5086256
Gene: Cxadr  Location: Chr16:78098377-78156662 bp, + strand  Genetic Position: Chr16, 45.28 cM, cytoband C
Alliance: Cxadrtm1.1Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174138
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was flanked with loxP sites and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. RT-PCR, western blot and indirect immunofluorescence confirmed normal mRNA and protein expression and localization in homozygous mice. (J:174138)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxadr Mutation:  15 strains or lines available
References
Original:  J:174138 Pazirandeh A, et al., Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene. PLoS One. 2011;6(6):e20203
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory