Shox2
Gene Detail

Symbol Name ID

Shox2 short stature homeobox 2 MGI:1201673

Synonyms

6330543G17Rik, Og12x, Prx3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

30.76 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr3:66971727-66981771 bp, - strand From VEGA annotation of GRCm38   10045 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68535  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Shox2

Human homologs

Human Homolog		SHOX2, short stature homeobox 2
NCBI Gene ID		6474
neXtProt AC		NX_O60902
Human Synonyms		OG12, OG12X, SHOT
Human Chr (Location)		3q25.32; chr3:157813800-157823952 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygous null mice display incomplete penetrance of embryonic lethality during organogenesis and incomplete clefting of the anterior part of the palate.

 
Human Diseases Modeled Using Mouse Shox2 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cardiac atrium morphogenesis, cartilage development involved in endochondral bone morphogenesis, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (60 records)
Data Summary: Results (153)    Tissues (124)    Images (38)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	134
Northern blot	12
RT-PCR	7

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(5) cDNA(16) Primer pair(5) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000042120 (Evidence)
Ensembl Gene Model	ENSMUSG00000027833 (Evidence)
Entrez Gene	20429 (Evidence)
DFCI	TC1586659, TC1594475, TC1612158
DoTS	DT.101362287, DT.101715829, DT.91328729
NIA Mouse Gene Index	U024124
Consensus CDS Project	CCDS17393.1
International Mouse Knockout Project Status	Shox2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042120	VEGA Gene Model | MGI Sequence Detail	10045	C57BL/6J
transcript	OTTMUST00000089115	VEGA | MGI Sequence Detail	2071	Not Applicable
polypeptide	OTTMUSP00000048652	VEGA | MGI Sequence Detail	331	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000014850	short stature homeobox protein 2

References

(Earliest) J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
(Latest) J:193588 Ammirabile G, et al., Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium. Cardiovasc Res. 2012 Feb 1;93(2):291-301
All references(89)

Other accession IDs

MGD-MRK-37044, MGI:108010, MGI:2445091