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Shox2
Gene Detail
Symbol

Name
ID
Shox2
short stature homeobox 2
MGI:1201673
Synonyms
6330543G17Rik, Og12x, Prx3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.76 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:66971727-66981771 bp, - strand
From VEGA annotation of GRCm38

  10045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SHOX2
Gene Tree: Shox2

Human
homologs
SHOX2, short stature homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6474
neXtProt AC: NX_O60902

Human Synonyms: OG12, OG12X, SHOT

Human Chr (Location): 3q25.32; chr3:158096011-158106202 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display incomplete penetrance of embryonic lethality during organogenesis and incomplete clefting of the anterior part of the palate.
 
Human Diseases Modeled in Mice Using Shox2 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Shox2 interacts with 285 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (79 records)
Data Summary: Results (204)    Tissues (144)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 176
Northern blot 12
RT-PCR 16
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase shox2 ; ZFIN shox2    NEW 
Molecular
reagents
All nucleic(34) Genomic(5) cDNA(17) Primer pair(7) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000042120 (Evidence)
Ensembl Gene Model ENSMUSG00000027833 (Evidence)
Entrez Gene 20429 (Evidence)
DFCI TC1594475, TC1586659, TC1691237, TC1612158
DoTS DT.97408784, DT.101362287, DT.91328729, DT.101715829
NIA Mouse Gene Index U024124
Consensus CDS Project CCDS17393.1
International Mouse Phenotyping Consortium Status Shox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042120 VEGA Gene Model | MGI Sequence Detail 10045 C57BL/6J ±  kb
transcript OTTMUST00000089115 VEGA | MGI Sequence Detail 3079 Not Applicable 
polypeptide OTTMUSP00000048652 VEGA | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(14) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000014850 short stature homeobox protein 2
References
(Earliest) J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
(Latest) J:219823 Rosin JM, et al., Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
All references(111)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37044, MGI:108010, MGI:2445091

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory