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Shox2
Gene Detail
 Symbol
Name
ID
Shox2
short stature homeobox 2
MGI:1201673
Synonyms 6330543G17Rik, Og12x, Prx3
Feature Type protein coding gene
Genetic Map
Chromosome 3
30.76 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:66971727-66981771 bp, - strand
From VEGA annotation of GRCm38

  10045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Shox2

Human
homologs
Human Homolog SHOX2, short stature homeobox 2
NCBI Gene ID 6474
neXtProt AC  NX_O60902
Human Synonyms  OG12, OG12X, SHOT
Human Chr (Location)  3q25.32; chr3:158096011-158106163 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display incomplete penetrance of embryonic lethality during organogenesis and incomplete clefting of the anterior part of the palate.
 
Human Diseases Modeled Using Mouse Shox2 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Shox2 interacts with 286 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cardiac atrium morphogenesis, cartilage development involved in endochondral bone morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (156)    Tissues (126)    Images (41)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 137
Northern blot 12
RT-PCR 7
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(5) cDNA(16) Primer pair(5) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000042120 (Evidence)
Ensembl Gene ModelENSMUSG00000027833 (Evidence)
Entrez Gene20429 (Evidence)
DFCITC1586659, TC1594475, TC1612158
DoTSDT.101362287, DT.101715829, DT.91328729
NIA Mouse Gene IndexU024124
Consensus CDS ProjectCCDS17393.1
International Mouse Knockout Project StatusShox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042120 VEGA Gene Model | MGI Sequence Detail 10045 C57BL/6J ±  kb
transcript OTTMUST00000089115 VEGA | MGI Sequence Detail 2071 Not Applicable 
polypeptide OTTMUSP00000048652 VEGA | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000014850 short stature homeobox protein 2
References (Earliest) J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
(Latest) J:209070 Glaser A, et al., Tbx4 interacts with the short stature homeobox gene Shox2 in limb development. Dev Dyn. 2014 May;243(5):629-39
All references(103)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37044, MGI:108010, MGI:2445091

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory