Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of cell development; and regulation of branching morphogenesis of a nerve. Acts upstream of or within several processes, including heart development; positive regulation of cell population proliferation; and skeletal system development. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; genitourinary system; and limb mesenchyme. Used to study Leri-Weill dyschondrosteosis. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human SHOX2 (SHOX homeobox 2).