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Cer1 Gene Detail
Summary
  • Symbol
    Cer1
  • Name
    cerberus 1, DAN family BMP antagonist
  • Synonyms
    cer-1, Cerberus-like, Cerl, Cerl1, Cerr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201414
    NCBI Gene: 12622
  • Gene Overview
    MyGene.info: CER1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:82881751-82885148 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3398 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 39.40 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAND4
  • Links
    NCBI Gene ID: 9350
    neXtProt AC: NX_O95813
    UniProt: O95813

  • Chr Location
    9p22.3; chr9:14715082-14724308 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 5 genetic backgrounds
    29 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000410 VEGA Gene Model | MGI Sequence Detail 3398 C57BL/6J ±  kb
    transcript OTTMUST00000000986 VEGA | MGI Sequence Detail 1739 Not Applicable  
    polypeptide OTTMUSP00000000437 VEGA | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      168 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 27
      Primer pair 5
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:894319
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 187
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
    • Latest
      J:257216 Takaoka K, et al., Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos. Nat Commun. 2017 Nov 14;8(1):1492

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory