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Cer1 Gene Detail
Summary
  • Symbol
    Cer1
  • Name
    cerberus 1, DAN family BMP antagonist
  • Synonyms
    cer-1, Cerberus-like, Cerl, Cerl1, Cerr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201414
    NCBI Gene: 12622
Location & Maps
more
  • Sequence Map
    Chr4:82881751-82885148 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3398 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CER1, cerberus 1, DAN family BMP antagonist
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DAND4
  • Links
    NCBI Gene ID: 9350
    neXtProt AC: NX_O95813

  • Chr Location
    9p23-p22; chr9:14719733-14722717 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 5 genetic backgrounds
    29 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    3 involving Cer1
  • Incidental Mutations
    APF
Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000410 VEGA Gene Model | MGI Sequence Detail 3398 C57BL/6J ±  kb
transcript OTTMUST00000000986 VEGA | MGI Sequence Detail 1739 Not Applicable  
polypeptide OTTMUSP00000000437 VEGA | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 39
    Genomic 1
    cDNA 27
    Primer pair 5
    Other 6

    Microarray probesets 4
Other
Accession IDs
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MGI:894319
References
more
  • Summaries
    All 205
    Developmental Gene Expression 177
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
  • Latest
    J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory