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Cer1
Gene Detail
 Symbol
Name
ID
Cer1
cerberus 1 homolog (Xenopus laevis)
MGI:1201414
Synonyms cer-1, Cerberus-like, Cerl, Cerl1, Cerr1
Feature Type protein coding gene
Genetic Map
Chromosome 4
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:82881751-82885148 bp, - strand
From VEGA annotation of GRCm38

  3398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cerberus
Gene Tree: Cer1

Human
homologs
Human Homolog CER1, cerberus 1, DAN family BMP antagonist
NCBI Gene ID 9350
neXtProt AC  NX_O95813
Human Synonyms  DAND4
Human Chr (Location)  9p23-p22; chr9:14719733-14722717 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.
 
Interactions
Cer1 interacts with 137 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process anterior/posterior axis specification, anterior/posterior pattern specification, ...
Component extracellular region, extracellular space
Function BMP binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (170 records)
Data Summary: Results (397)    Tissues (177)    Images (141)
Theiler Stages: 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 22, 28
Assay TypeResults
RNA in situ 343
RT-PCR 37
RNase protection 17
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(27) Primer pair(5) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000410 (Evidence)
Ensembl Gene ModelENSMUSG00000038192 (Evidence)
Entrez Gene12622 (Evidence)
UniGene6780
DFCITC1591067
DoTSDT.87068100
Consensus CDS ProjectCCDS18295.1
International Mouse Knockout Project StatusCer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000410 VEGA Gene Model | MGI Sequence Detail 3398 C57BL/6J ±  kb
transcript OTTMUST00000000986 VEGA | MGI Sequence Detail 1739 Not Applicable 
polypeptide OTTMUSP00000000437 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016860 Cerberus
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
Protein Ontology PR:000005361 cerberus
References (Earliest) J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
(Latest) J:205039 Hiramatsu R, et al., External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos. Dev Cell. 2013 Oct 28;27(2):131-44
All references(201)
Other
accession IDs
MGI:894319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory