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Cer1
Gene Detail
Symbol

Name
ID
Cer1
cerberus 1 homolog (Xenopus laevis)
MGI:1201414
Synonyms
cer-1, Cerberus-like, Cerl, Cerl1, Cerr1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:82881751-82885148 bp, - strand
From VEGA annotation of GRCm38

  3398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CER1
Protein SuperFamily: cerberus
Gene Tree: Cer1

Human
homologs
CER1, cerberus 1, DAN family BMP antagonist
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9350
neXtProt AC: NX_O95813

Human Synonyms: DAND4

Human Chr (Location): 9p23-p22; chr9:14719733-14722717 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.
 
Interactions
Cer1 interacts with 138 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process anterior/posterior axis specification, anterior/posterior pattern specification, ...
Component extracellular region, extracellular space
Function BMP binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (175 records)
Data Summary: Results (397)    Tissues (177)    Images (141)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 343
RT-PCR 37
RNase protection 17
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CER1 ; Xenbase cer1    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(27) Primer pair(5) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000410 (Evidence)
Ensembl Gene Model ENSMUSG00000038192 (Evidence)
Entrez Gene 12622 (Evidence)
UniGene 6780
DFCI TC1591067
DoTS DT.87068100
Consensus CDS Project CCDS18295.1
International Mouse Phenotyping Consortium Status Cer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000410 VEGA Gene Model | MGI Sequence Detail 3398 C57BL/6J ±  kb
transcript OTTMUST00000000986 VEGA | MGI Sequence Detail 1739 Not Applicable 
polypeptide OTTMUSP00000000437 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016860 Cerberus
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR004133 DAN
Protein Ontology PR:000005361 cerberus
References
(Earliest) J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
(Latest) J:221169 Kumar A, et al., Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. Dev Biol. 2015 Apr 1;400(1):1-9
All references(205)
Other
accession IDs
MGI:894319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory