Cer1
Gene Detail

Symbol Name ID

Cer1 cerberus 1 homolog (Xenopus laevis) MGI:1201414

Synonyms

cer-1, Cerberus-like, Cerl, Cerl1, Cerr1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:82881751-82885148 bp, - strand From VEGA annotation of GRCm38   3398 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cer1 ± 2 cM)

Protein SuperFamily: cerberus
Gene Tree: Cer1

Human ortholog

CER1 cerberus 1, DAN family BMP antagonist NCBI Gene ID 9350
Human Synonyms: DAND4
Human Chr9:14719731-14722715 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for most disruptions in this gene appear normal although one allele displays behavioral abnormalities and a mild increase in body weight with age.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	anterior/posterior axis specification, anterior/posterior pattern specification, ...
Component	extracellular region, extracellular space
Function	BMP binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (162 records)
Data Summary: Results (379)    Tissues (172)    Images (126)
Theiler Stages: 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 22, 28

Assay Type	Results
RNA in situ	325
RT-PCR	37
RNase protection	17

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(1) cDNA(27) Primer pair(5) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000410 (Evidence)
Ensembl Gene Model	ENSMUSG00000038192 (Evidence)
Entrez Gene	12622 (Evidence)
UniGene	6780
DFCI	TC1591067
DoTS	DT.87068100
Consensus CDS Project	CCDS18295.1
International Mouse Knockout Project Status	Cer1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000410	VEGA Gene Model | MGI Sequence Detail	3398	C57BL/6J
transcript	OTTMUST00000000986	VEGA | MGI Sequence Detail	1739	Not Applicable
polypeptide	OTTMUSP00000000437	VEGA | MGI Sequence Detail	272	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016860	Cerberus
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR004133	DAN
Protein Ontology	PR:000005361	cerberus

References

(Earliest) J:44900 Belo JA, et al., Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 1997 Nov;68(1-2):45-57
(Latest) J:193728 Hong M, et al., Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet. 2012;8(10):e1002999
All references(193)

Other accession IDs

MGI:894319