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Pknox1
Gene Detail
 Symbol
Name
ID
Pknox1
Pbx/knotted 1 homeobox
MGI:1201409
Synonyms D17Wsu76e, PREP1
Feature Type protein coding gene
Genetic Map
Chromosome 17
16.78 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:31564749-31607684 bp, + strand
From VEGA annotation of GRCm38

  42936 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Pknox1

Human
homologs
Human Homolog PKNOX1, PBX/knotted 1 homeobox 1
NCBI Gene ID 5316
neXtProt AC  NX_P55347
Human Synonyms  pkonx1c, PREP1
Human Chr (Location)  21q22.3; chr21:42974510-43033931 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(240) : Gene trapped(227) Targeted(13)
Genomic Mutations involving Pknox1 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development with variable penetrance, decreased body weight, and impaired T cell development.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Pknox1 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process angiogenesis, camera-type eye development, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (209)    Tissues (175)    Images (16)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 135
Northern blot 1
Western blot 9
RT-PCR 32
RNase protection 20
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(16) Primer pair(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040106 (Evidence)
Ensembl Gene ModelENSMUSG00000006705 (Evidence)
Entrez Gene18771 (Evidence)
DFCITC1580994, TC1613380, TC1635220
DoTSDT.110556564, DT.490209, DT.97362547, DT.97365895
NIA Mouse Gene IndexU043583
Consensus CDS ProjectCCDS28608.1
International Mouse Knockout Project StatusPknox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040106 VEGA Gene Model | MGI Sequence Detail 42936 C57BL/6J ±  kb
transcript OTTMUST00000104193 VEGA | MGI Sequence Detail 4172 Not Applicable 
polypeptide OTTMUSP00000058286 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(13) UniProt(1)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012788 homeobox protein PKNOX1
References (Earliest) J:45106 Knoepfler PS, et al., Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14553-8
(Latest) J:207764 Kanzleiter T, et al., Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle. Mol Cell Biol. 2014 Jan;34(2):290-8
All references(84)
Other
accession IDs
MGD-MRK-33976, MGI:106284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory