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Pknox1
Gene Detail
Symbol

Name
ID
Pknox1
Pbx/knotted 1 homeobox
MGI:1201409
Synonyms
D17Wsu76e, PREP1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
16.78 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:31564749-31607684 bp, + strand
From VEGA annotation of GRCm38

  42936 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

HCOP human homology predictions: PKNOX1
Gene Tree: Pknox1

Human
homologs
PKNOX1, PBX/knotted 1 homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5316
neXtProt AC: NX_P55347

Human Synonyms: pkonx1c, PREP1

Human Chr (Location): 21q22.3; chr21:42974510-43033931 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(240) : Gene trapped(227) Targeted(13)
Genomic Mutations involving Pknox1 (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development with variable penetrance, decreased body weight, and impaired T cell development.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Pknox1 interacts with 313 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process angiogenesis, camera-type eye development, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (201)    Tissues (170)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 127
Northern blot 1
Western blot 9
RT-PCR 32
RNase protection 20
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497777 ; ZFIN pknox1.2    NEW 
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(17) Primer pair(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000040106 (Evidence)
Ensembl Gene Model ENSMUSG00000006705 (Evidence)
Entrez Gene 18771 (Evidence)
DFCI TC1635220, TC1613380, TC1580994
DoTS DT.110556564, DT.490209, DT.97365895, DT.97362547
NIA Mouse Gene Index U043583
Consensus CDS Project CCDS28608.1
International Mouse Phenotyping Consortium Status Pknox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040106 VEGA Gene Model | MGI Sequence Detail 42936 C57BL/6J ±  kb
transcript OTTMUST00000104191 VEGA | MGI Sequence Detail 2272 Not Applicable 
polypeptide OTTMUSP00000058285 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(13) UniProt(1)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012788 homeobox protein PKNOX1
References
(Earliest) J:45106 Knoepfler PS, et al., Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14553-8
(Latest) J:220635 Modica L, et al., Prep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway. PLoS One. 2014;9(9):e107916
All references(84)
Other
accession IDs
MGD-MRK-33976, MGI:106284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory