Pknox1
Gene Detail

Symbol Name ID

Pknox1 Pbx/knotted 1 homeobox MGI:1201409

Synonyms

D17Wsu76e, PREP1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

16.78 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr17:31564749-31607680 bp, + strand From VEGA annotation of GRCm38   42932 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pknox1 ± 2 cM)

Gene Tree: Pknox1

Human ortholog

PKNOX1 PBX/knotted 1 homeobox 1 NCBI Gene ID 5316
Human Synonyms: pkonx1c, PREP1
Human Chr21:44394643-44453688 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(236) : Targeted(9) Gene trapped(227)
 

Homozygous mutation of this gene results in embryonic lethality during fetal growth and development with variable penetrance, decreased body weight, and impaired T cell development.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	angiogenesis, camera-type eye development, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (190)    Tissues (156)    Images (15)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	109
Northern blot	1
Western blot	9
RT-PCR	39
RNase protection	20

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(16) Primer pair(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000040106 (Evidence)
Ensembl Gene Model	ENSMUSG00000006705 (Evidence)
Entrez Gene	18771 (Evidence)
DFCI	TC1580994, TC1613380, TC1635220
DoTS	DT.110556564, DT.490209, DT.97362547, DT.97365895
NIA Mouse Gene Index	U043583
Consensus CDS Project	CCDS28608.1
International Mouse Knockout Project Status	Pknox1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040106	VEGA Gene Model | MGI Sequence Detail	42932	C57BL/6J
transcript	OTTMUST00000104191	VEGA | MGI Sequence Detail	2283	Not Applicable
polypeptide	OTTMUSP00000058285	VEGA | MGI Sequence Detail	436	Not Applicable

All sequences(50) RefSeq(3) UniProt(1)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000012788	homeobox protein PKNOX1

References

(Earliest) J:45106 Knoepfler PS, et al., Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14553-8
(Latest) J:192251 Iotti G, et al., Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis. PLoS One. 2012;7(10):e48353
All references(80)

Other accession IDs

MGD-MRK-33976, MGI:106284