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Irx3 Gene Detail
Summary
  • Symbol
    Irx3
  • Name
    Iroquois related homeobox 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197522
    NCBI Gene: 16373
  • Gene Overview
    MyGene.info: IRX3
Location & Maps
more
  • Sequence Map
    Chr8:91798525-91802067 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3543 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 44.55 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    IRX3, iroquois homeobox 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    IRX3, iroquois homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRX-1, IRXB1
  • Links
    NCBI Gene ID: 79191
    neXtProt AC: NX_P78415

  • Chr Location
    16q12.2; chr16:54283300-54286856 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display right bundle branch block, decreased body weight, increased energy expenditure, reduced adiposity and decreased susceptibility to diet induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040086 VEGA Gene Model | MGI Sequence Detail 3543 C57BL/6J ±  kb
transcript OTTMUST00000117195 VEGA | MGI Sequence Detail 2610 Not Applicable  
polypeptide OTTMUSP00000065532 VEGA | MGI Sequence Detail 522 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 71
    cDNA 64
    Primer pair 3
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGI:2142650
References
more
  • Summaries
    All 130
    Developmental Gene Expression 103
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
  • Latest
    J:233374 Hayashi S, et al., Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet. 2016 Jun;12(6):e1006138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory