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Irx3
Gene Detail
Symbol

Name
ID
Irx3
Iroquois related homeobox 3
MGI:1197522
Feature Type
protein coding gene
Genetic Map
Chromosome 8
44.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:91798525-91801916 bp, - strand
From VEGA annotation of GRCm38

  3392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7385  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Irx3

Human
homologs
Human Homolog IRX3, iroquois homeobox 3
NCBI Gene ID 79191
neXtProt AC  NX_P78415
Human Synonyms  IRX-1, IRXB1
Human Chr (Location)  16q12.2; chr16:54283300-54286812 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display right bundle branch block.
 
Interactions
Irx3 interacts with 98 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process kidney development, mesoderm development, ...
Component axon, cytoplasm, ...
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (530)    Tissues (364)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 519
Northern blot 1
RT-PCR 8
cDNA source data(61)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(63) Primer pair(3) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000040086 (Evidence)
Ensembl Gene ModelENSMUSG00000031734 (Evidence)
Entrez Gene16373 (Evidence)
UniGene238044
DFCITC1581533
DoTSDT.530359
NIA Mouse Gene IndexU030093
Consensus CDS ProjectCCDS57630.1, CCDS57631.1
International Mouse Knockout Project StatusIrx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040086 VEGA Gene Model | MGI Sequence Detail 3392 C57BL/6J ±  kb
transcript OTTMUST00000117195 VEGA | MGI Sequence Detail 2610 Not Applicable 
polypeptide OTTMUSP00000065532 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000031095 iroquois-class homeodomain protein IRX-3
References
(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:213418 Li D, et al., Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
All references(125)
Other
accession IDs
MGI:2142650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory