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Irx3
Gene Detail
Symbol

Name
ID
Irx3
Iroquois related homeobox 3
MGI:1197522
Feature Type
protein coding gene
Genetic Map
Chromosome 8
44.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:91798525-91801916 bp, - strand
From VEGA annotation of GRCm38

  3392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7385  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: IRX3
Gene Tree: Irx3

Human
homologs
IRX3, iroquois homeobox 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 79191
neXtProt AC: NX_P78415

Human Synonyms: IRX-1, IRXB1

Human Chr (Location): 16q12.2; chr16:54283300-54286856 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display right bundle branch block, decreased body weight, increased energy expenditure, reduced adiposity and decreased susceptibility to diet induced obesity.
 
Interactions
Irx3 interacts with 98 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process kidney development, mesoderm development, ...
Component axon, cytoplasm, ...
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (97 records)
Data Summary: Results (530)    Tissues (364)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 519
Northern blot 1
RT-PCR 8
cDNA source data(61)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase irx3 ; ZFIN irx3a, irx3b    NEW 
Molecular
reagents
All nucleic(70) cDNA(63) Primer pair(3) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000040086 (Evidence)
Ensembl Gene Model ENSMUSG00000031734 (Evidence)
Entrez Gene 16373 (Evidence)
UniGene 238044
DFCI TC1581533
DoTS DT.530359
NIA Mouse Gene Index U030093
Consensus CDS Project CCDS57630.1, CCDS57631.1
International Mouse Phenotyping Consortium Status Irx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040086 VEGA Gene Model | MGI Sequence Detail 3392 C57BL/6J ±  kb
transcript OTTMUST00000117195 VEGA | MGI Sequence Detail 2610 Not Applicable 
polypeptide OTTMUSP00000065532 VEGA | MGI Sequence Detail 522 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000031095 iroquois-class homeodomain protein IRX-3
References
(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
All references(127)
Other
accession IDs
MGI:2142650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory