Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; kidney development; and regulation of transcription by RNA polymerase II. Acts upstream of or within mesoderm development; negative regulation of neuron differentiation; and positive regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3).