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Bcl2l11
Gene Detail
 Symbol
Name
ID
Bcl2l11
BCL2-like 11 (apoptosis facilitator)
MGI:1197519
Synonyms 1500006F24Rik, Bim, Bod
Feature Type protein coding gene
Genetic Map
Chromosome 2
62.23 cM, cytoband F3-G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:128126038-128162547 bp, + strand
From VEGA annotation of GRCm38

  36510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 western clawed frog

Protein SuperFamily: Bcl-2-like protein 11
Gene Tree: Bcl2l11

Human
homologs
Human Homolog BCL2L11, BCL2-like 11 (apoptosis facilitator)
NCBI Gene ID 10018
neXtProt AC  NX_O43521
Human Synonyms  BAM, BIM, BOD
Human Chr (Location)  2q13; chr2:111120914-111168445 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(14) Targeted(16)
Incidental mutations (data from APF )
 
Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.
 
Interactions
Bcl2l11 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component BIM-BCL-2 complex, BIM-BCL-xl complex, ...
Function microtubule binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (12)    Tissues (3)    Images (7)
Theiler Stages: 14, 20, 23
Assay TypeResults
RNA in situ 9
Western blot 3
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000015356 (Evidence)
Ensembl Gene ModelENSMUSG00000027381 (Evidence)
Entrez Gene12125 (Evidence)
DFCITC1585175, TC1595207, TC1602099, TC1613056, TC1641340, TC1650552, TC1667650, TC1760036
DoTSDT.101361961, DT.101362249, DT.103564406, DT.491390, DT.55142853, DT.91333163, DT.94262404, DT.94295620, DT.99594815, DT.99856321
NIA Mouse Gene IndexU002444
PDB1PQ1
Consensus CDS ProjectCCDS16712.1, CCDS16713.1, CCDS16714.1, CCDS71141.1
International Mouse Knockout Project StatusBcl2l11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015356 VEGA Gene Model | MGI Sequence Detail 36510 C57BL/6J ±  kb
transcript OTTMUST00000036398 VEGA | MGI Sequence Detail 5036 Not Applicable 
polypeptide OTTMUSP00000016362 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014771 Apoptosis, Bim N-terminal
InterPro IPR017288 Bcl-2-like protein 11
InterPro IPR015040 Bcl-x interacting
Protein Ontology PR:000002187 bcl-2-like protein 11
References (Earliest) J:45671 O'Connor L, et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95
(Latest) J:211065 Park H, et al., Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7066-71
All references(274)
Other
accession IDs
MGI:1923589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory