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Bcl2l11
Gene Detail
Symbol

Name
ID
Bcl2l11
BCL2-like 11 (apoptosis facilitator)
MGI:1197519
Synonyms
1500006F24Rik, Bim, Bod
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.23 cM, cytoband F3-G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:128126038-128162547 bp, + strand
From VEGA annotation of GRCm38

  36510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 western clawed frog

HCOP human homology predictions: BCL2L11
Protein SuperFamily: Bcl-2-like protein 11
Gene Tree: Bcl2l11

Human
homologs
BCL2L11, BCL2-like 11 (apoptosis facilitator)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10018
neXtProt AC: NX_O43521

Human Synonyms: BAM, BIM, BOD

Human Chr (Location): 2q13; chr2:111120618-111168445 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(14) Targeted(16)
Incidental mutations (data from APF )
 
Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.
 
Interactions
Bcl2l11 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (12)    Tissues (3)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Western blot 3
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bcl2l11 ; ZFIN bcl2l11    NEW 
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000015356 (Evidence)
Ensembl Gene Model ENSMUSG00000027381 (Evidence)
Entrez Gene 12125 (Evidence)
DFCI TC1650552, TC1641340, TC1613056, TC1602099, TC1595207, TC1667650, TC1585175, TC1760036
DoTS DT.103564406, DT.491390, DT.101362249, DT.101361961, DT.99594815, DT.99856321, DT.94262404, DT.94295620, DT.91333163, DT.55142853
NIA Mouse Gene Index U002444
PDB 1PQ1
Consensus CDS Project CCDS16712.1, CCDS16713.1, CCDS16714.1, CCDS71141.1
International Mouse Phenotyping Consortium Status Bcl2l11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015356 VEGA Gene Model | MGI Sequence Detail 36510 C57BL/6J ±  kb
transcript OTTMUST00000036398 VEGA | MGI Sequence Detail 5036 Not Applicable 
polypeptide OTTMUSP00000016362 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(18) UniProt(5)
Polymorphisms
SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014771 Apoptosis, Bim N-terminal
InterPro IPR017288 Bcl-2-like protein 11
InterPro IPR015040 Bcl-x interacting
Protein Ontology PR:000002187 Bcl-2-like protein 11
References
(Earliest) J:45671 O'Connor L, et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95
(Latest) J:221272 Delbridge AR, et al., Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis. Oncogene. 2015 Apr 2;34(14):1872-6
All references(279)
Other
accession IDs
MGI:1923589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory