Bcl2l11
Gene Detail

Symbol Name ID

Bcl2l11 BCL2-like 11 (apoptosis facilitator) MGI:1197519

Synonyms

1500006F24Rik, Bim, Bod

Feature Type

protein coding gene

Genetic Map

Chromosome 2

62.23 cM, cytoband F3-G1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:128126038-128162547 bp, + strand From VEGA annotation of GRCm38   36510 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Protein SuperFamily: Bcl-2-like protein 11
Gene Tree: Bcl2l11

Human homologs

Human Homolog		BCL2L11, BCL2-like 11 (apoptosis facilitator)
NCBI Gene ID		10018
neXtProt AC		NX_O43521
Human Synonyms		BAM, BIM, BOD
Human Chr (Location)		2q13; chr2:111878491-111926022 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(26) : Targeted(12) Gene trapped(14)
 

Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.

 

Gene Ontology (GO) classifications

All GO classifications: (66 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	BIM-BCL-2 complex, BIM-BCL-xl complex, ...
Function	microtubule binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (12)    Tissues (3)    Images (7)
Theiler Stages: 14, 20, 23

Assay Type	Results
RNA in situ	9
Western blot	3

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000015356 (Evidence)
Ensembl Gene Model	ENSMUSG00000027381 (Evidence)
Entrez Gene	12125 (Evidence)
DFCI	TC1585175, TC1595207, TC1602099, TC1613056, TC1641340, TC1650552, TC1667650, TC1760036
DoTS	DT.101361961, DT.101362249, DT.103564406, DT.491390, DT.55142853, DT.91333163, DT.94262404, DT.94295620, DT.99594815, DT.99856321
NIA Mouse Gene Index	U002444
PDB	1PQ1
Consensus CDS Project	CCDS16712.1, CCDS16713.1, CCDS16714.1
International Mouse Knockout Project Status	Bcl2l11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015356	VEGA Gene Model | MGI Sequence Detail	36510	C57BL/6J
transcript	OTTMUST00000036398	VEGA | MGI Sequence Detail	5036	Not Applicable
polypeptide	OTTMUSP00000016362	VEGA | MGI Sequence Detail	196	Not Applicable

All sequences(82) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(197 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014771	Apoptosis, Bim N-terminal
InterPro	IPR017288	Bcl-2-like protein 11
InterPro	IPR015040	Bcl-x interacting
Protein Ontology	PR:000002187	bcl-2-like protein 11

References

(Earliest) J:45671 O'Connor L, et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95
(Latest) J:193405 Knell J, et al., Id2 Influences Differentiation of Killer Cell Lectin-like Receptor G1hi Short-Lived CD8+ Effector T Cells. J Immunol. 2013 Feb 15;190(4):1501-9
All references(242)

Other accession IDs

MGI:1923589