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Bcl2l11
Gene Detail
Symbol

Name
ID
Bcl2l11
BCL2-like 11 (apoptosis facilitator)
MGI:1197519
Synonyms
1500006F24Rik, Bim, Bod
Feature Type
protein coding gene
Genetic Map
Chromosome 2
62.23 cM, cytoband F3-G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:128126038-128162547 bp, + strand
From VEGA annotation of GRCm38

  36510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 western clawed frog

Protein SuperFamily: Bcl-2-like protein 11
Gene Tree: Bcl2l11

Human
homologs
Human Homolog BCL2L11, BCL2-like 11 (apoptosis facilitator)
NCBI Gene ID 10018
neXtProt AC  NX_O43521
Human Synonyms  BAM, BIM, BOD
Human Chr (Location)  2q13; chr2:111120914-111168445 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(14) Targeted(16)
Incidental mutations (data from APF )
 
Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.
 
Interactions
Bcl2l11 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (12)    Tissues (3)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Western blot 3
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(24)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015356 VEGA Gene Model | MGI Sequence Detail 36510 C57BL/6J ±  kb
transcript OTTMUST00000036398 VEGA | MGI Sequence Detail 5036 Not Applicable 
polypeptide OTTMUSP00000016362 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(18) UniProt(5)
Polymorphisms
SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014771 Apoptosis, Bim N-terminal
InterPro IPR017288 Bcl-2-like protein 11
InterPro IPR015040 Bcl-x interacting
Protein Ontology PR:000002187 bcl-2-like protein 11
References
(Earliest) J:45671 O'Connor L, et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998 Jan 15;17(2):384-95
(Latest) J:211065 Park H, et al., Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7066-71
All references(274)
Other
accession IDs
MGI:1923589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory