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Irx1
Gene Detail
Symbol

Name
ID
Irx1
Iroquois related homeobox 1 (Drosophila)
MGI:1197515
Feature Type
protein coding gene
Genetic Map
Chromosome 13
38.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:71957921-71963723 bp, - strand
From VEGA annotation of GRCm38

  5803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Irx1

Human
homologs
Human Homolog IRX1, iroquois homeobox 1
NCBI Gene ID 79192
neXtProt AC  NX_P78414
Human Synonyms  IRX-5, IRXA1
Human Chr (Location)  5p15.3; chr5:3596054-3601403 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Irx1 interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (592)    Tissues (316)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 588
Northern blot 1
RT-PCR 3
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) cDNA(86) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040082 (Evidence)
Ensembl Gene ModelENSMUSG00000060969 (Evidence)
Entrez Gene16371 (Evidence)
UniGene316056
DFCITC1682589
DoTSDT.488124
NIA Mouse Gene IndexU122000
Consensus CDS ProjectCCDS26627.1
International Mouse Knockout Project StatusIrx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040082 VEGA Gene Model | MGI Sequence Detail 5803 C57BL/6J ±  kb
transcript OTTMUST00000104122 VEGA | MGI Sequence Detail 2373 Not Applicable 
polypeptide OTTMUSP00000058240 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000032290 iroquois-class homeodomain protein IRX-1
References
(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory