Irx1 MGI Mouse Gene Detail - MGI:1197515

Irx1 Gene Detail

Symbol

Irx1
Name

Iroquois homeobox 1

Feature Type

protein coding gene
IDs

MGI:1197515
NCBI Gene: 16371
Gene Overview

MyGene.info: IRX1
Alliance

gene page

Sequence Map

Chr13:71957921-71963723 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

5803 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 38.43 cM
Mapping Data

4 experiments

Human Ortholog

IRX1, iroquois homeobox 1

Vertebrate Orthologs

10

Human Ortholog

IRX1, iroquois homeobox 1
Orthology source: HomoloGene, HGNC
Synonyms

IRX-5, IRXA1
Links

HGNC:14358

NCBI Gene ID: 79192

neXtProt AC: NX_P78414

UniProt: P78414
Chr Location

5p15.33; chr5:3595855-3601403 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 19065
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: IRX1
Gene Tree

Irx1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Irx1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

9 strains or lines available

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All GO Annotations

7
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

673
Tissues

379
cDNA Data

87
Literature Summary

39

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IRX1

Xenbase irx1

ZFIN irx1a, irx1b

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Irx1 interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

27
RefSeq

2
UniProt

3
CCDS

CCDS26627.1
UniGene

316056

			Length	Strain/Species	Flank
genomic	OTTMUSG00000040082	VEGA Gene Model \| MGI Sequence Detail	5803	C57BL/6J	± kb
transcript	OTTMUST00000104122	VEGA \| MGI Sequence Detail	2373	Not Applicable
polypeptide	OTTMUSP00000058240	VEGA \| MGI Sequence Detail	480	Not Applicable

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SNPs within 2kb

37 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
Protein Ontology

PR:000032290 iroquois-class homeodomain protein IRX-1

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR003893 Iroquois-class homeodomain protein

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All nucleic 89

cDNA 87

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 72

Developmental Gene Expression 39

Gene Ontology 3

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:248919 Yu W, et al., Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation. Dev Biol. 2017 Sep 1;429(1):44-55

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2018 MGI 6.11