Irx1
Gene Detail

Symbol

Name
ID

Irx1
Iroquois related homeobox 1 (Drosophila)
MGI:1197515

Feature Type

protein coding gene

Genetic Map

Chromosome 13
38.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr13:71957921-71963723 bp, - strand From VEGA annotation of GRCm38   5803 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:19065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Irx1

Human
homologs

Human Homolog		IRX1, iroquois homeobox 1
NCBI Gene ID		79192
neXtProt AC		NX_P78414
Human Synonyms		IRX-5, IRXA1
Human Chr (Location)		5p15.3; chr5:3596054-3601403 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Irx1 interacts with 128 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Process	regulation of transcription, DNA-templated
Component	nucleus
Function	DNA binding, sequence-specific DNA binding

External Resources: FuncBase

Expression

Literature Summary: (32 records)

Data Summary: Results (592)    Tissues (316)    Images (99)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	588
Northern blot	1
RT-PCR	3

cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(88) cDNA(86) Primer pair(1) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000040082 (Evidence)
Ensembl Gene Model	ENSMUSG00000060969 (Evidence)
Entrez Gene	16371 (Evidence)
UniGene	316056
DFCI	TC1682589
DoTS	DT.488124
NIA Mouse Gene Index	U122000
Consensus CDS Project	CCDS26627.1
International Mouse Knockout Project Status	Irx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040082	VEGA Gene Model | MGI Sequence Detail	5803	C57BL/6J
transcript	OTTMUST00000104122	VEGA | MGI Sequence Detail	2373	Not Applicable
polypeptide	OTTMUSP00000058240	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003893	Iroquois-class homeodomain protein
Protein Ontology	PR:000032290	iroquois-class homeodomain protein IRX-1

References

(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(61)