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Irx1 Gene Detail
Summary
  • Symbol
    Irx1
  • Name
    Iroquois related homeobox 1 (Drosophila)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197515
    NCBI Gene: 16371
Location & Maps
more
  • Sequence Map
    Chr13:71957921-71963723 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5803 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRX1, iroquois homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRX1, iroquois homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRX-5, IRXA1
  • Links
    NCBI Gene ID: 79192
    neXtProt AC: NX_P78414

  • Chr Location
    5p15.3; chr5:3596054-3601403 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 19065
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: IRX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Irx1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040082 VEGA Gene Model | MGI Sequence Detail 5803 C57BL/6J ±  kb
transcript OTTMUST00000104122 VEGA | MGI Sequence Detail 2373 Not Applicable  
polypeptide OTTMUSP00000058240 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 89
    cDNA 87
    Primer pair 1
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 59
    Developmental Gene Expression 33
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
  • Latest
    J:227021 Mallika C, et al., Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory