Irx1
Gene Detail

Symbol Name ID

Irx1 Iroquois related homeobox 1 (Drosophila) MGI:1197515

Feature Type

protein coding gene

Genetic Map

Chromosome 13

38.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr13:71957921-71963723 bp, - strand From VEGA annotation of GRCm38   5803 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Irx1

Human homologs

Human Homolog		IRX1, iroquois homeobox 1
NCBI Gene ID		79192
neXtProt AC		NX_P78414
Human Synonyms		IRX-5, IRXA1
Human Chr (Location)		5p15.3; chr5:3596054-3601403 (+)  GRCh38

Alleles and phenotypes

All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	regulation of transcription, DNA-templated
Component	nucleus
Function	DNA binding, sequence-specific DNA binding

External Resources: FuncBase

Expression

Literature Summary: (31 records)

Data Summary: Results (592)    Tissues (316)    Images (99)
Theiler Stages: 9, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	588
Northern blot	1
RT-PCR	3

cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(88) cDNA(86) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000040082 (Evidence)
Ensembl Gene Model	ENSMUSG00000060969 (Evidence)
Entrez Gene	16371 (Evidence)
UniGene	316056
DFCI	TC1682589
DoTS	DT.488124
NIA Mouse Gene Index	U122000
Consensus CDS Project	CCDS26627.1
International Mouse Knockout Project Status	Irx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040082	VEGA Gene Model | MGI Sequence Detail	5803	C57BL/6J
transcript	OTTMUST00000104122	VEGA | MGI Sequence Detail	2373	Not Applicable
polypeptide	OTTMUSP00000058240	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003893	Iroquois-class homeodomain protein
Protein Ontology	PR:000032290	iroquois-class homeodomain protein IRX-1

References

(Earliest) J:45683 Bosse A, et al., Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev. 1997 Dec;69(1-2):169-81
(Latest) J:194051 Heliot C, et al., HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
All references(60)