Irx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irx1
Iroquois homeobox 1
MGI:1197515

27 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irx1^{tm1(KOMP)Vlcg}/Irx1^{tm1(KOMP)Vlcg} involves: C57BL/6NTac	abnormal ameloblast differentiation	J:248919
	abnormal dental epithelium morphology	J:248919
	abnormal lower incisor morphology	J:248919
	abnormal lung development	J:248919
	abnormal odontoblast morphology	J:248919
	abnormal outer dental epithelium morphology	J:248919
	abnormal respiratory mechanics	J:248919
	abnormal stratum intermedium morphology	J:248919
	abnormal tooth development	J:248919
	absent gastric milk in neonates	J:248919
	atelectasis	J:248919
	cyanosis	J:248919
	decreased surfactant secretion	J:248919
	growth retardation of incisors	J:248919
	neonatal lethality, complete penetrance	J:248919
	respiratory distress	J:248919
	respiratory failure	J:248919
	short lower incisors	J:248919
	small lower incisors	J:248919
	small lung	J:248919
Irx1^{tm1.1(KOMP)Vlcg}/Irx1⁺ C57BL/6N-Irx1^{tm1.1(KOMP)Vlcg}/J	decreased locomotor activity	J:211773
	decreased thigmotaxis	J:211773
Irx1^{tm1.1(KOMP)Vlcg}/Irx1^{tm1.1(KOMP)Vlcg} C57BL/6N-Irx1^{tm1.1(KOMP)Vlcg}/J	abnormal abdominal wall morphology	J:211773
	abnormal craniofacial morphology	J:211773
	abnormal embryo size	J:211773
	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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