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Sumo1 Gene Detail
Summary
  • Symbol
    Sumo1
  • Name
    small ubiquitin-like modifier 1
  • Synonyms
    PIC1, SENTRIN, Smt3C, Ubl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197010
    NCBI Gene: 22218
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:59639434-59670834 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.32 cM, cytoband C2-C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197010
protein coding gene Chr1:59586558-59670834 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016068
protein coding gene Chr1:59555861-59650348 (-)
A/J MGP_AJ_G0016051
protein coding gene Chr1:57489858-57576093 (-)
AKR/J MGP_AKRJ_G0016007
protein coding gene Chr1:59099160-59191056 (-)
BALB/cJ MGP_BALBcJ_G0016006
protein coding gene Chr1:57519605-57605076 (-)
C3H/HeJ MGP_C3HHeJ_G0015838
protein coding gene Chr1:59345698-59432674 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016459
protein coding gene Chr1:61908523-62000494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014180
protein coding gene Chr1:53304553-53383949 (-)
CAST/EiJ MGP_CASTEiJ_G0015420
protein coding gene Chr1:58514268-58610857 (-)
CBA/J MGP_CBAJ_G0015810
protein coding gene Chr1:63838555-63933186 (-)
DBA/2J MGP_DBA2J_G0015911
protein coding gene Chr1:56913209-57003833 (-)
FVB/NJ MGP_FVBNJ_G0015913
protein coding gene Chr1:56217136-56305540 (-)
LP/J MGP_LPJ_G0015983
protein coding gene Chr1:60454557-60543444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015933
protein coding gene Chr1:66745860-66852824 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016506
protein coding gene Chr1:59003534-59094063 (-)
PWK/PhJ MGP_PWKPhJ_G0015207
protein coding gene Chr1:56251097-56339641 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014987
protein coding gene Chr1:58549793-58635133 (-)
WSB/EiJ MGP_WSBEiJ_G0015483
protein coding gene Chr1:58715120-58801967 (-)



Homology
more
  • Human Ortholog
    SUMO1, small ubiquitin-like modifier 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUMO1, small ubiquitin-like modifier 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
  • Links
    NCBI Gene ID: 7341
    neXtProt AC: NX_P63165
    UniProt: P63165

  • Chr Location
    2q33.1; chr2:202206180-202238599 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SUMO1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Knockout mice are viable with no testis or palate defects. Homozygotes for one gene-trap allele are viable and overtly normal, although MEFs have fewer PML nuclear bodies. Closer analysis of mice derived from another gene-trap line verified normal viability and palatogenesis in heterozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22218 NCBI Gene Model | MGI Sequence Detail 31401 C57BL/6J ±  kb
    transcript NM_009460 RefSeq | MGI Sequence Detail 1230 C57BL/6  
    polypeptide P63166 UniProt | EBI | MGI Sequence Detail 101 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      Genomic 3
      cDNA 140
      Primer pair 3
      Other 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 18
      Gene Ontology 21
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261820 Gong L, et al., Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3987-E3995

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory