Sumo1
Gene Detail

Symbol Name ID

Sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) MGI:1197010

Synonyms

PIC1, SENTRIN, Smt3C, Ubl1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

30.32 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:59639434-59670834 bp, - strand From VEGA annotation of GRCm38   31401 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small ubiquitin-related modifier 1
Gene Tree: Sumo1

Human homologs

Human Homolog		SUMO1, SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
NCBI Gene ID		7341
neXtProt AC		NX_P63165
Human Synonyms		DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
Human Chr (Location)		2q33; chr2:203070903-203103322 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SUMO1

Alleles and phenotypes

All alleles(164) : Targeted(5) Gene trapped(159)
 

Knockout mice are viable with no testis or palate defects. Homozygotes for one gene-trap allele are viable and overtly normal, although MEFs have fewer PML nuclear bodies. Closer analysis of mice derived from another gene-trap line verified normal viability and palatogenesis in heterozygotes.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	negative regulation of DNA binding, negative regulation of sequence-specific DNA binding transcription factor activity, ...
Component	cytoplasm, dendrite, ...
Function	protein binding, SUMO ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (2)    Tissues (1)    Images (4)
Theiler Stages: 28

Assay Type	Results
Immunohistochemistry	2

cDNA source data(136)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(141) Genomic(3) cDNA(138)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022159 (Evidence)
Ensembl Gene Model	ENSMUSG00000026021 (Evidence)
Entrez Gene	22218 (Evidence)
UniGene	362118
DFCI	TC1573401, TC1752688
DoTS	DT.110942011, DT.495250, DT.91377567
NIA Mouse Gene Index	U021371, U057995
Consensus CDS Project	CCDS35586.1
International Mouse Knockout Project Status	Sumo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022159	VEGA Gene Model | MGI Sequence Detail	31401	C57BL/6J
transcript	OTTMUST00000052620	VEGA | MGI Sequence Detail	1215	Not Applicable
polypeptide	OTTMUSP00000024972	VEGA | MGI Sequence Detail	101	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(94 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000626	Ubiquitin
InterPro	IPR019955	Ubiquitin supergroup
Protein Ontology	PR:000015829	small ubiquitin-related modifier 1

References

(Earliest) J:46976 Shen Z, et al., UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. Genomics. 1996 Sep 1;36(2):271-9
(Latest) J:193101 Tirard M, et al., In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21122-7
All references(69)