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Sumo1
Gene Detail
Symbol

Name
ID
Sumo1
small ubiquitin-like modifier 1
MGI:1197010
Synonyms
PIC1, SENTRIN, Smt3C, Ubl1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.32 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:59586558-59670834 bp, - strand
From VEGA annotation of GRCm38

  84277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SUMO1
Protein SuperFamily: small ubiquitin-related modifier 1
Gene Tree: Sumo1

Human
homologs
SUMO1, small ubiquitin-like modifier 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7341
neXtProt AC: NX_P63165

Human Synonyms: DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1

Human Chr (Location): 2q33; chr2:202206180-202238599 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SUMO1

Mutations,
alleles, and
phenotypes
All mutations/alleles(166) : Gene trapped(161) Targeted(5)
 
Knockout mice are viable with no testis or palate defects. Homozygotes for one gene-trap allele are viable and overtly normal, although MEFs have fewer PML nuclear bodies. Closer analysis of mice derived from another gene-trap line verified normal viability and palatogenesis in heterozygotes.
 
Interactions
Sumo1 interacts with 144 markers (Mir7-1, Mir15a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (60)    Tissues (30)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 9
In situ reporter (knock in) 2
Western blot 27
RT-PCR 8
cDNA source data(137)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sumo1    NEW 
Molecular
reagents
All nucleic(146) Genomic(3) cDNA(139) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022159 (Evidence)
Ensembl Gene Model ENSMUSG00000026021 (Evidence)
Entrez Gene 22218 (Evidence)
UniGene 362118
DFCI TC1752688, TC1573401
DoTS DT.495250, DT.91377567, DT.110942011
NIA Mouse Gene Index U057995, U021371
Consensus CDS Project CCDS35586.1
International Mouse Phenotyping Consortium Status Sumo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022159 VEGA Gene Model | MGI Sequence Detail 84277 C57BL/6J ±  kb
transcript OTTMUST00000052620 VEGA | MGI Sequence Detail 1215 Not Applicable 
polypeptide OTTMUSP00000024972 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022617 Small ubiquitin-related modifier, SUMO
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000015829 small ubiquitin-related modifier 1
References
(Earliest) J:46976 Shen Z, et al., UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. Genomics. 1996 Sep 1;36(2):271-9
(Latest) J:222135 Lee GY, et al., PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling. Mol Cell Biol. 2014 Mar;34(6):926-38
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory