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Sumo1
Gene Detail
 Symbol
Name
ID
Sumo1
SMT3 suppressor of mif two 3 homolog 1 (yeast)
MGI:1197010
Synonyms PIC1, SENTRIN, Smt3C, Ubl1
Feature Type protein coding gene
Genetic Map
Chromosome 1
30.32 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:59639434-59670834 bp, - strand
From VEGA annotation of GRCm38

  31401 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small ubiquitin-related modifier 1
Gene Tree: Sumo1

Human
homologs
Human Homolog SUMO1, small ubiquitin-like modifier 1
NCBI Gene ID 7341
neXtProt AC  NX_P63165
Human Synonyms  DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
Human Chr (Location)  2q33; chr2:202206180-202238599 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SUMO1
Alleles
and
phenotypes
All alleles(164) : Targeted(5) Gene trapped(159)
 
Knockout mice are viable with no testis or palate defects. Homozygotes for one gene-trap allele are viable and overtly normal, although MEFs have fewer PML nuclear bodies. Closer analysis of mice derived from another gene-trap line verified normal viability and palatogenesis in heterozygotes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process negative regulation of DNA binding, negative regulation of sequence-specific DNA binding transcription factor activity, ...
Component cytoplasm, dendrite, ...
Function poly(A) RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (2)    Tissues (1)    Images (4)
Theiler Stages: 28
Assay TypeResults
Immunohistochemistry 2
cDNA source data(137)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(142) Genomic(3) cDNA(139)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022159 (Evidence)
Ensembl Gene ModelENSMUSG00000026021 (Evidence)
Entrez Gene22218 (Evidence)
UniGene362118
DFCITC1573401, TC1752688
DoTSDT.110942011, DT.495250, DT.91377567
NIA Mouse Gene IndexU021371, U057995
Consensus CDS ProjectCCDS35586.1
International Mouse Knockout Project StatusSumo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022159 VEGA Gene Model | MGI Sequence Detail 31401 C57BL/6J ±  kb
transcript OTTMUST00000052620 VEGA | MGI Sequence Detail 1215 Not Applicable 
polypeptide OTTMUSP00000024972 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000015829 small ubiquitin-related modifier 1
References (Earliest) J:46976 Shen Z, et al., UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. Genomics. 1996 Sep 1;36(2):271-9
(Latest) J:198680 Sharma P, et al., Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo. Cell Rep. 2013 May 30;3(5):1640-50
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory