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Sumo1
Gene Detail
Symbol

Name
ID
Sumo1
SMT3 suppressor of mif two 3 homolog 1 (yeast)
MGI:1197010
Synonyms
PIC1, SENTRIN, Smt3C, Ubl1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.32 cM, cytoband C2-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:59586558-59670834 bp, - strand
From VEGA annotation of GRCm38

  84277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small ubiquitin-related modifier 1
Gene Tree: Sumo1

Human
homologs
Human Homolog SUMO1, small ubiquitin-like modifier 1
NCBI Gene ID 7341
neXtProt AC  NX_P63165
Human Synonyms  DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
Human Chr (Location)  2q33; chr2:202206180-202238599 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SUMO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(167) : Gene trapped(162) Targeted(5)
 
Knockout mice are viable with no testis or palate defects. Homozygotes for one gene-trap allele are viable and overtly normal, although MEFs have fewer PML nuclear bodies. Closer analysis of mice derived from another gene-trap line verified normal viability and palatogenesis in heterozygotes.
 
Interactions
Sumo1 interacts with 144 markers (Mir7-1, Mir15a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (2)    Tissues (1)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
cDNA source data(137)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(142) Genomic(3) cDNA(139)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022159 (Evidence)
Ensembl Gene ModelENSMUSG00000026021 (Evidence)
Entrez Gene22218 (Evidence)
UniGene362118
DFCITC1752688, TC1573401
DoTSDT.91377567, DT.495250, DT.110942011
NIA Mouse Gene IndexU057995, U021371
Consensus CDS ProjectCCDS35586.1
International Mouse Knockout Project StatusSumo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022159 VEGA Gene Model | MGI Sequence Detail 84277 C57BL/6J ±  kb
transcript OTTMUST00000052620 VEGA | MGI Sequence Detail 1215 Not Applicable 
polypeptide OTTMUSP00000024972 VEGA | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(400 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000015829 small ubiquitin-related modifier 1
References
(Earliest) J:46976 Shen Z, et al., UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. Genomics. 1996 Sep 1;36(2):271-9
(Latest) J:208871 Gong L, et al., Sumoylation differentially regulates Sp1 to control cell differentiation. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5574-9
All references(75)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory