Gene Expression Literature Summary

• Symbol: Sumo1
• Name: small ubiquitin-like modifier 1
• ID: MGI:1197010

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E2	E2.5	E3	E3.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)									3	1	2	2	2	2	1	1	3	1	1	2		7
In situ RNA (section)														1
Immunohistochemistry (whole mount)	1	1	1	1	1
In situ RNA (whole mount)						1	1	2	3	2	1		1
In situ reporter (knock in)										1			1									1
Western blot								1		1	2	3		1	2	2		1	2		3	10
RT-PCR						1		2	1			1	1	1		1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sumo1  small ubiquitin-like modifier 1   (Synonyms: PIC1, SENTRIN, Smt3C, Ubl1)
Results	Reference
3*	J:112841 Alkuraya FS, Saadi I, Lund JJ, Turbe-Doan A, Morton CC, Maas RL, SUMO1 haploinsufficiency leads to cleft lip and palate. Science. 2006 Sep 22;313(5794):1751
1	J:141453 Cheng J, Kang X, Zhang S, Yeh ET, SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
6*	J:177922 Costa MW, Lee S, Furtado MB, Xin L, Sparrow DB, Martinez CG, Dunwoodie SL, Kurtenbach E, Mohun T, Rosenthal N, Harvey RP, Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One. 2011;6(9):e24812
1*	J:257087 Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M, Analysis of SUMO1-conjugation at synapses. Elife. 2017 Jun 9;6:e26338
2	J:141678 Evdokimov E, Sharma P, Lockett SJ, Lualdi M, Kuehn MR, Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J Cell Sci. 2008 Dec 15;121(Pt 24):4106-13
2*	J:228859 Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W, Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet. 2014 Oct;10(10):e1004579
5	J:315590 Fujiwara K, Hasegawa K, Oka M, Yoneda Y, Yoshikawa K, Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system. Genes Cells. 2016 Nov;21(11):1176-1194
8*	J:208871 Gong L, Ji WK, Hu XH, Hu WF, Tang XC, Huang ZX, Li L, Liu M, Xiang SH, Wu E, Woodward Z, Liu YZ, Nguyen QD, Li DW, Sumoylation differentially regulates Sp1 to control cell differentiation. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5574-9
8	J:215364 Hasegawa Y, Yoshida D, Nakamura Y, Sakakibara S, Spatiotemporal distribution of SUMOylation components during mouse brain development. J Comp Neurol. 2014 Sep 1;522(13):3020-36
1	J:162938 Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET, SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23;38(2):191-201
1	J:183651 Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J, Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012 Mar;52(3):638-49
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
2	J:276298 Lewandowski SL, Janardhan HP, Trivedi CM, Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-beta1 (TGF-beta1) to Orchestrate Second Heart Field Development. J Biol Chem. 2015 Nov 6;290(45):27067-89
1	J:294283 Liang Q, Zheng Q, Zuo Y, Chen Y, Ma J, Ni P, Cheng J, SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Rep. 2019 Aug 20;28(8):2004-2011.e4
1	J:309380 Mei L, Qv M, Bao H, He Q, Xu Y, Zhang Q, Shi W, Ren Q, Yan Z, Xu C, Tang C, Hussain M, Zeng LH, Wu X, SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling. Oncogene. 2021 Sep;40(35):5357-5366
1*	J:155888 Rodriguez-Magadan H, Ramirez L, Schnabel D, Vazquez M, Lomeli H, Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads. Gene Expr Patterns. 2010 Jan;10(1):16-23
1	J:327192 Rossitto M, Dejardin S, Rands CM, Le Gras S, Migale R, Rafiee MR, Neirijnck Y, Pruvost A, Nguyen AL, Bossis G, Cammas F, Le Gallic L, Wilhelm D, Lovell-Badge R, Boizet-Bonhoure B, Nef S, Poulat F, TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway. Nat Commun. 2022 Jul 29;13(1):4412
5*	J:320687 Sheban D, Shani T, Maor R, Aguilera-Castrejon A, Mor N, Oldak B, Shmueli MD, Eisenberg-Lerner A, Bayerl J, Hebert J, Viukov S, Chen G, Kacen A, Krupalnik V, Chugaeva V, Tarazi S, Rodriguez-delaRosa A, Zerbib M, Ulman A, Masarwi S, Kupervaser M, Levin Y, Shema E, David Y, Novershtern N, Hanna JH, Merbl Y, SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Mol Cell. 2022 Jan 6;82(1):106-122.e9
1	J:226978 Tateossian H, Morse S, Simon MM, Dean CH, Brown SD, Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42
2	J:260447 Usui N, Araujo DJ, Kulkarni A, Co M, Ellegood J, Harper M, Toriumi K, Lerch JP, Konopka G, Foxp1 regulation of neonatal vocalizations via cortical development. Genes Dev. 2017 Oct 15;31(20):2039-2055
1	J:320313 Usui N, Co M, Harper M, Rieger MA, Dougherty JD, Konopka G, Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development. Biol Psychiatry. 2017 Feb 1;81(3):220-230
5	J:325290 Wang J, Chen L, Wen S, Zhu H, Yu W, Moskowitz IP, Shaw GM, Finnell RH, Schwartz RJ, Defective sumoylation pathway directs congenital heart disease. Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):468-76
7*	J:217019 Wang L, Wansleeben C, Zhao S, Miao P, Paschen W, Yang W, SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. EMBO Rep. 2014 Aug;15(8):878-85
4	J:99175 Yamaguchi T, Sharma P, Athanasiou M, Kumar A, Yamada S, Kuehn MR, Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol Cell Biol. 2005 Jun;25(12):5171-82
8	J:167158 Yan Q, Gong L, Deng M, Zhang L, Sun S, Liu J, Ma H, Yuan D, Chen PC, Hu X, Liu J, Qin J, Xiao L, Huang XQ, Zhang J, Wan-Cheng Li D, Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21034-9
6*	J:298019 Zhang X, Wang C, Zhao D, Chen X, Zhang C, Zheng J, Liu X, Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. PLoS One. 2020;15(11):e0242606